Search
36 articles for “Schiff bases”
-
Optical Absorption and Electronic Properties of 4-Aminoantipyrine Schiff’s Bases: A Combined Experimental and DFT Study
Abstract: The Schiff base compounds (A1–A9) have been synthesized and characterized by elemental analysis, FT-IR, UV-Vis, mass spectrometry, 1H-NMR and 13C-NMR. Electronic absorption spectra of A1–A9 are studied in various solvents with different polarity like hexane, chloroform, methanol and dimethyl sulfoxide. To support and better understanding of experimental results, density functional theory (DFT), time dependent density functional theory (TDDFT) calculations has been carried out for these molecules and are in good …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 8, Issue 1, 2017 · pp. 1–13 Read article
-
Synthesis, Structural Characterization and Biological Studies of Schiff Base Complexes Bearing Indole Moiety
Abstract: Schiff base complexes of N2O2 type derived from indole-3-carboxaldehyde(ind) and amino acids such as glycine(gly), L-valine(val), and L-tryptophan(try) with Cu(II), Ni(II), Zn(II), Co(II) and Mn(II) were synthesized and characterized by physical and analytical techniques. The complexes are of non-electrolytic nature having 1:2 (metal:ligand) ratio. The geometry of the complexes was predicted with the combined data obtained from electronic spectral and magnetic susceptibility measurements. The mode of coordination of the Schiff …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 4, Issue 1, 2013 · pp. 31–42 Read article
-
Green Solvents in Synthesis of Schiff’s Base: A Comprehensive Review of Sustainable Approach
Abstract: The synthesis of Schiffs & bases is a fundamental process of organic synthesis that traditionally involves using hazardous organic solvents. These solvents pose significant risks to both the environment and human health due to their toxicity, volatility, and persistence in nature. These negative effects of organic solvents have led to the development of greener and more sustainable alternatives that aligns with the principles of Green Chemistry. This review paper aims …
Published in Emerging Trends in Chemical Engineering · Vol. 11, Issue 3, 2024 · pp. 30–40 Read article
-
Synthesis and antibacterial studies of some bivalent transition metal ions Zn (II), Cu (II) and Ni (II) complexes of Schiff’s base derived from some substituted aromatic aldehydes.
Abstract: In this study, Schiff bases were synthesised through the condensation of aromatic aldehydes with primary amines and subsequently complexed with Ni(II),Zn(II) and Cu(II) ions. The formation of the metal complexes was confirmed by FTIR spectroscopy, which identified the key functional groups involved in coordination. The biological activity of the prepared compounds were studied with the help of selected bacteria like E. coli , Pseudomonas. and B. sereus.. The results obtained …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 96–104 Read article
-
Synergistic and Antagonistic Effects of Azo-Schiff Base with Some Antibiotics on Gram-Positive Bacterial Isolates
Abstract: Antibacterial resistance has brought an urgent need to find a solution to the problem of antibacterial resistance and increase the effectiveness of antibiotics. Therefore, our current study was aimed to test the three concentrations viz., 0.5 mg/ml, 5 mg/ml and 50 mg/ml of Azo-Schiff base against Grampositive bacteria—Bacillus cereus, Micrococcus lutes, Staphylococcus aureus—to compare the effects of Schiff base alone or along with antibiotics on the viability of bacteria. Our …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 2, 2021 · pp. 25–31 Read article
-
Synergistic and Antagonistic Effects of Azo-Schiff Base with Some Antibiotics on Gram-Positive Bacterial Isolates
Abstract: Antibacterial resistance has brought an urgent need to find a solution to the problem of antibacterial resistance and increase the effectiveness of antibiotics. Therefore, our current study was aimed to test the three concentrations viz., 0.5 mg/ml, 5 mg/ml and 50 mg/ml of Azo-Schiff base against Gram-positive bacteria—Bacillus cereus, Micrococcus lutes, Staphylococcus aureus—to compare the effects of Schiff base alone or along with antibiotics on the viability of bacteria. Our …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 2, 2021 · pp. 25–31 Read article
-
Synthesis and Characterization of a Naphthalene-Derived Schiff Base for Fe³⁺ Sensing Applications
Abstract: The development of chemosensors for metal ions has gained significant attention due to their crucial role in industrial, environmental, and biological applications. Metal ion detection is essential for monitoring environmental pollution, industrial processes, and biological systems where metal homeostasis plays a vital role. In this study, we focus on the synthesis, characterization, and application of a novel naphthalene-based Schiff base ligand, derived from the condensation reaction between 1,8-diaminonaphthalene and 3-nitrobenzaldehyde. …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 1–8 Read article
-
Production and Characterization of Cardanol Based Schiff Complexes and their Biological Significance
Abstract: Synthesis and analysis of cardanol consisted Schiff base ligand along with its complexes such as Cu, Co and Ni are considered as a novel tetradentate cardanol contained Schiff base ligand molecules for various biological effects. It is prepared by the condensation reaction of 2-aminophenol and di-α formylmethoxybis (3-pentadecenyl phenyl) methane which is termed as DFMPM in the molar ratio of 2:1. The characterization of the experimental compounds is done with …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 2, 2019 · pp. 19–24 Read article
-
Synthesis and Evaluation of Chalcone Derivatives and Schiff bases derivatives as Antibacterial
Abstract: AbstractSix substituted chalcones have been synthesized by condensing benzaldehyde derivatives with acetophenone in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen-Schmidt condensation. In addition, four of Schiff bases have been prepared via imine condensation between substituted benzaldehyde firstly with (3) 2-aminophenol, secondly, with phenylhydrazine. Moreover, study the efficient of synthesized compounds as antibacterial agents were evaluated. The structures of the synthesized compounds were confirmed by the melting …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 3, 2018 · pp. 1–7 Read article
-
Synthesis and Characterization of Co(II), Ni(II), Cu(II) and Zn(II) Complexes with Schiff Bases Derived from 3-Substituted-4-Amino-5-Mercapto-1,2,4-Triazoles and Ethylvanillin
Abstract: Normal 0 false false false MicrosoftInternetExplorer4 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 The synthesis and structural characterization of two novel compounds, 4-(3-ethoxy-4-hydroxybenzylideneamino)-3-methyl-5-mercapto-s-triazole and 3-ethyl-4-(3-ethoxy-4-hydroxybenzylideneamino)-5-mercapto-s-triazole and their Co(II), Ni(II), Cu(II), Zn(II) complexes in 1:1 and 1:2 molar ratio have been described with the help of different techniques like IR, 1H-NMR, magnetic moment, electronic spectra, thermal and XRD studies. The Schiff bases are coordinated to metal ion through S …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 4, Issue 2, 2013 · pp. 19–25 Read article
-
A Brief Review of Interaction of Schiff Base Complexes with DNA: A Perceptive to Anti-cancer Agents
Abstract: Owing to the importance in design and development of new antitherapeutic and anticancer drugs, the contemporary research in this field requires an extensive study and untired contribution of bio-chemists in addition to that of pharmacologists and medical professionals. Keeping in view the recent reports in this field, especially, giving attention to the studies on the interaction of Schiff base complexes with DNA has been reviewed briefly. The recent trends in …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 1, 2013 · pp. 13–19 Read article
-
QSAR Studies on Schiff Bases of Pyrrole-2-Carboxaldehyde for Antimicrobial Activity
Abstract: Pyrrole and Schiff bases are therapeutically significant organic moieties. QSAR (Quantitative structure-activity relationship) studies of thirteen pyrrole-2-carboxyaldehyde Schiff bases have been described for antimicrobial activity against S. epidermidis, E. coli and S. aureus. Described 2D QSAR models are statistically significant models with good fitting ability and robustness. The Q2 value is more than 0.5 for all discussed models which confirms the internal predictive power of the derived QSAR equations. Molecular …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 3, 2016 · pp. 1–8 Read article
-
Synthesis, Characterization and Biological Activity: Co(II), Ni(II), Cu(II) and Zn(II) Complexes of Schiff Bases Derived from 4-Cyanobenzaldehye and 4-Amino-5-Mercapto-3-Methyl/Ethyl-1,2,4-triazoles
Abstract: Co(II), Ni(II), Cu(II) and Zn(II) complexes of bidentate Schiff bases derived from the condensation of 4-amino-5-mercapto-3-methyl-1,2,4-triazole and 4-amino-3-ethyl-5-mercapto-1,2,4-triazole with 4-cyanobenzaldehyde have been synthesized. The synthesized Schiff bases and their metal complexes were then characterized by elemental analysis, spectroscopic methods (IR, NMR, electronic spectra), magnetic moment measurement and thermogravimetric techniques. The electronic spectra and magnetic moment studies suggest octahedral geometry for Co(II), Ni(II) and Zn(II) complexes and square planar geometry for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 5, Issue 2, 2014 · pp. 27–36 Read article
-
Synthesis and Characterization of Schiff Bases Derivatives of Heterotrimetallic [Al(III); Sn(II); Ti(IV)]-µ-oxoisopropoxide-µ-oxon-propoxide [SnO2TiAl(OPri )2(OPrn )3]
Abstract: Tin diacetate and aluminium isopropoxide in equimolar proportion in xylene affords the complex [(OAc)SnOAl(OPri )2] which on reaction with Ti(OPrn )4 in 1:1 molar ratio yielded a new organoheterotrimetallic-μ-oxoisopropoxide-μ-oxon-propoxide [SnO2TiAl(OPri )2(OPrn )3] with continuous liberation of isopropyl acetate and propyl acetate formed during the course of reaction. The preparation of Schiff base complexes of the compound [SnO2TiAl(OPri )2(OPrn )3] was carried out in refluxing benzene by the reaction of µ- …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 7, Issue 2, 2016 · pp. 27–37 Read article
-
Synthesis and Characterization of Pyrazole Heterocyclic Derivatives via Vilsmeier-Haack-Reaction and its Schiff`s Bases.
Abstract: The synthesis of New Schiff bases (2; and 3a-c) is reported in this study. These bases were created by reacting -chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (1) with various amines that contained various pharmacophore atoms or groups, such as derivatives of benzothiazole and aniline, in the hopes of having antimicrobial and antifungal properties. Using mild reaction conditions and a good yield percentage, mono-pyrazole Schiff bases (2 and 3a–c) were designed and synthesized by reacting 5-chloro--3-methyl-1-phenyl-pyrazole-4-carbaldehyde …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 34–48 Read article
-
Semiempirical Modeling and Docking Studies of Pyrrole-2-Carboxaldehyde Schiff Bases
Abstract: Docking stimulation of antimicrobial compound SB7 against the active site of Mandelate racemase has been accomplished. This compound was engaged in various types of interactions with the binding site residues. Further, molecular modeling of all the target compounds was performed using MOPAC 2016 and various parameters were identified. SB1, SB2 and SB5 were found to be most stable compounds and had highest dipole moment. The compound SB8 came out to …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 3, 2016 · pp. 9–15 Read article
-
Pt (II) Schiff Base Complex Catalyzed Oxidation of Internal and Terminal Alkenes
Abstract: Pt (II) complexes of Schiff base ligands were found highly efficient towards the catalytic oxidation of internal alkenes and terminal alkenes in dimethylformamide (DMF) solvent under normal pressure of molecular oxygen. In some catalytic reactions, H2O2 was also used as co-oxidant. No diminished catalytic activity was observed even after six to eight repeated catalytic runs. Effect of temperature and extra ligand etc. on the rate of oxidation, nature and percentage …
Published in Journal of Catalyst & Catalysis · Vol. 2, Issue 3, 2015 · pp. 7–15 Read article
-
Synthesis, Characterization and Evaluation of Pyridine derivatives
Abstract: Schiff bases, a class of organic compounds, have garnered significant attention due to their diverse applications in various fields such as pharmaceuticals, materials science, and coordination chemistry. This study provides a comprehensive overview of the synthesis of Schiff bases amino pyridine derivatives and aromatic ketones along with their anti-microbial activity. Method: The synthesis of Schiff bases primarily involves the condensation reaction between a primary amine and a carbonyl compound (ketone) …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 35–48 Read article
-
Synthesis, Characterization of New Imidazolidin-4-One Containing Azo Compound Derived from Acetylacetone as Antibacterial and Antioxidant Agents
Abstract: In the present study, new derivatives of imidazolidine-4-one was prepared. Which involved reactions to diazonium salt of o-methoxy aniline with acetylacetone in the presence of sodium hydroxide, and isolating the azo compound as a brown precipitate. The azo diketone reacts efficiently with aromatic amine derivatives to produce Schiff bases as a light yellow and dark brown precipitates, and from this Schiff bases three derivatives of imidazolidine-4-one was prepared by reacting …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 94–114 Read article
-
Anti-Escherichia coli Potentials of a Novel Chemical Compound 1-(2-hydroxy-1, 2-diphenylethylidene)-3-phenylthiourea
Abstract: Inspiration from the anti-infective excellence (anti-bacterial, anti-fungal, anti-viral, and anti-malarial) of Schiff’s base molecules as well as knowing the rising importance of low-molecular-weight ligands (LMWL), the present research involved the development of novel Schiff’s base compound utilizing very basic laboratory components; 1-phenylthiourea and benzoin using the conventional synthesis technique. The compounds were comprehensively characterized through sophisticated instruments and further screened for anti-microbial activity against pathogenic Escherichia coli (E. coli, MTCC …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 1, 2020 · pp. 9–12 Read article