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42 articles for “Randomized Clinical Trial”
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Significance of Randomized Clinical Trials
Abstract: The most exacting and reliable research tool for determining if there is a cause-and-effect relationship between an intervention and a result is the randomized controlled trial. When assessing the efficacy and safety of an intervention, a randomized controlled trial can produce high-quality evidence. Every randomized controlled trial (RCT) ought to have predetermined primary outcomes, be registered with a clinical trials database, and possess the necessary ethical permissions. The quality of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 3, 2023 · pp. 12–16 Read article
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Comparison of Temporalis Fasia and Cartilage Graft in Tympanoplasty Type 1: A Randomized Clinical Trial
Abstract: To compare the clinical and audiological outcomes of the type 1 tympanoplasty performed with either tragal composite island graft or temporalis fascia graft, in patients with chronic otitis media. Pateints with chronic otitis media with medium and large central perforation, dry ear at least for one month, intact ossicular chain were included in randomized clinical trial. Out of 40 subjects, 20 cases were repaired with tragal composite island graft and …
Published in Research and Reviews : Journal of Surgery · Vol. 4, Issue 1, 2015 · pp. 5–11 Read article
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An Open Labelled Parallel Arm Randomized Clinical Trial of Tuvaraka Oil Prepared By Two Different Method In The Management of Pama
Abstract: In Ayurveda, all skin diseases have classified mainly into two groups i.e., Mahakushtha (major skin diseases) and Kshudrakushtha (minor skin diseases). Tuvaraka [Hydnocarpus laurifolia (Dessnt).Sleumer] is one among the most useful drugs for the treatment of Kushtha (Various skin diseases) and Madhumeha (Diabetes Melitus). Pama is described under Kshudra Kushtha. which can be correlates with scabies. Aim: To evaluate the clinical efficacy of Tuvaraka oil prepared by modified method and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 29–36 Read article
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A Study to Assess the Add-on Impact of Ayurvedic Management along with Ongoing Conventional Treatment of Diabetes Mellitus: A Randomized Clinical Trial
Abstract: Diabetes affects millions and thus is a major public health disease among with adults aged 30+. Available treatment although helps but many develop other side effects to complicate the issue. Ayurveda offers options to manage diabetes without complications. Present study is to see the add-on effect of Ayurveda therapy among persons on modern medicines. Ayurveda D4 combination is Jamunbeej and Gudmarpatra 5 gm churna each before breakfast and dinner and …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · pp. 15–22 Read article
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A Study to Assess the Add-on Impact of Ayurvedic Management along with Ongoing Conventional Treatment of Diabetes Mellitus: A Randomized Clinical Trial
Abstract: Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disbalance of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, action, or both. Diabetes affects millions and thus is a major public health disease among with adults aged 30+. Available treatment although helps but many develop other side effects to complicate the issue. Ayurveda offers options to manage diabetes without complications. Present study …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 8, Issue 1, 2021 · pp. 15–22 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial
Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article
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A Comparative Clinical Trial of Three Different Dosage form of Guduchi (Tinospora Cordifolia Willd.) in Ekakustha (Psoriasis)
Abstract: Introduction: Ekakushtha is a type of Kshudra Kushtha (minor skin disease) resembling psoriasis in its clinical manifestations. Guduchi (Tinospora cordifolia Willd.) is mentioned very effective in treatment of all type Kushtha in classics with different dosage forms like Ghana (aqueous extract), Churna (powder drug), Ghrita, hydro alcoholic extract and many more. Aim: To evaluate the clinical efficacy of three different dosage form of Guduchi i.e. Guduchi Ghana prepared from Guduchi …
Published in Research & Reviews : Journal of Herbal Science · Vol. 12, Issue 3, 2023 · pp. 30–39 Read article
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Psychiatric Diseases: First Do No Harm—Evidence-Based Medicine
Abstract: Evidence-based drugs is an approach to medical practices that uses the results of patient care research and other available objectives evidence as a component of clinical decision making to provide the best drug equality. Evidence-based medicine (EBM) does not replace clinical judgment with the current best evidence. Evidence-based medicine seeks the best existing evidence from basic science to clinical research with which to inform clinical decision. Evidence-based medicine gives actual …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 31–37 Read article
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Intermittent Fasting: Exploring the Benefits and Risks of Intermittent Fasting for Weight Loss and Overall Health
Abstract: Perception in Intermittent Fasting: One novel approach for managing weight is intermittent fasting (IF) which is gaining more popularity in recent days. This research investigates advantages and disadvantages of IF with an emphasis on its impact on metabolic processes, cardiovascular health, cognitive abilities, and changes in hormone levels. Methods: A literature review comprising randomized clinical trials, cohort studies, and meta-analyses of peer-reviewed publications was performed. A resolution was obtained by …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 24–29 Read article
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Second Generation Platelet Rich Concentrates and Their Role in Periodontal Therapy: A Review
Abstract: Periodontal tissue regeneration has always been a challenge for the periodontists. Regeneration of lost tooth supporting structure by periodontitis is a primary goal of periodontal therapy. Platelet rich blood derivatives have been widely used in the field of dentistry. In recent years, platelet rich blood derivatives have gained more attention in periodontal regeneration. Platelet rich blood derivative which include platelet-rich plasma (PRP), platelet-rich fibrin (PRF), platelet-derived growth factors (PDGF), have …
Published in Research and Reviews: A Journal of Dentistry · Vol. 10, Issue 1, 2019 · pp. 24–30 Read article
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Effect of Hijama Bil Shart (Wet Cupping Therapy) in Treatment of Waja‘ al-Zahr (Low Backache): A Randomized Standard Controlled Clinical Study
Abstract: Introduction: Low back pain (Waja‘ al-Zahr) is one of the common musculoskeletal problems. It affects 80% population and accounts for considerable health care and profound economic burden. Disabilities in activities of daily living are common due to low back pain. Despite advancement in medicine, the standard conventional treatment often fails to achieve optimal results. Unani physicians recommended various modes of treatment to manage musculoskeletal disorders through intervention of specific regimens …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 10, Issue 2, 2021 · pp. 9–14 Read article
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Nanocrystalline Silver–Carbon
Abstract: This study is on the properties of nanocrystalline silver products and examines on the internal relation between silver and carbon particles. Nanocrystalline utilizes nanotechnology to release nanocrystalline silver crystals. Nanocrystalline releases 60 times fewer silver cations than silver–carbon interaction in between strongly. Silver impregnated fast releases dressings release minute concentrations of silver which are quickly bounds up by the chloride in the wound exudates. The silver and carbon ions are …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 2, 2018 · pp. 27–29 Read article
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Prospective Evaluation of the Optimal Concentration and Effect of Epinephrine as an Adjuvant to Local Anesthetics for Prolonging Block Duration and Reducing Systemic Toxicity in Outpatient Surgery
Abstract: Purpose: To evaluate the optimal concentration and effect of epinephrine as an adjuvant to local anesthetics for prolonging block duration and reducing systemic toxicity in outpatient surgery. Methods: The study involved a randomized double-blind clinical trial on 80 adult patients awaiting day-care extremity surgery. The patients were randomly assigned to two groups of equal size. One group, Group E, was given the local anesthetic agent along with epinephrine as an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 64–69 Read article
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Preoperative Use of Midazolam vs Dexmedetomidine for Anxiolysis in Day-Care Surgery
Abstract: Surgical procedures trigger significant fear and anxiety that can adversely affect physiological responses and recovery outcomes. This prospective, randomized, double-blinded clinical trial compared the anxiolytic efficacy and safety of intravenous midazolam and dexmedetomidine in 60 patients undergoing day-care surgery. Primary outcomes included anxiety scores measured by STAI and sedation assessed by the OAAS scale at multiple perioperative time points. Secondary outcomes assessed in the study included detailed evaluation of hemodynamic …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 7–12 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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HPV and Cardiovascular Risk: Unpacking a Novel Link Between Viral Infection and Heart Disease
Abstract: Human papillomavirus (HPV) is best known for its oncogenic potential, yet a growing body of evidence suggests that persistent HPV infection may also contribute to cardiovascular disease (CVD). In 2025, pooled analyses and conference reports galvanized attention by estimating that HPV‐positive individuals have ~40% higher risk of CVD and approximately double the risk of coronary artery disease (CAD) compared with HPV‐negative peers, even after adjustment for traditional risk factors. These …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 1–5 Read article
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Management of Uterine Sarcomas - Current Concepts and Controversies
Abstract: Uterine sarcomas are a group of relatively rare malignancies with heterologous clinical behavior. Because of its rarity, there is dearth of randomized trials and hence there are no standard recommendations as how to manage these cases. Carcinosarcomas are now a separate entity and is managed similar to high grade endometrial carcinoma, since the sarcomatous element is proven to be of endometrial origin. Now, the major variants are leomyosarcoma (LMS), endometrial …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 3, 2015 · pp. 19–26 Read article
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Advances in Total Knee Replacement: A Systematic Review of Clinical Outcomes and Complications
Abstract: Total Knee Replacement (TKR) is a widely used surgical intervention for patients with knee osteoarthritis and other degenerative knee disorders, offering significant improvements in pain relief, functional restoration, and quality of life. This systematic review synthesizes data from multiple clinical studies to evaluate the outcomes and complications associated with TKR. To find applicable research published in the last ten years, a thorough search of electronic databases was performed. Randomised controlled …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 41–56 Read article
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Electroconvulsive Therapy in the Management of Schizophrenia: A Systematic Review in Emergency Nursing Practice
Abstract: Electroconvulsive therapy (ECT) is a well-established treatment for various psychiatric disorders, including schizophrenia, particularly in cases where patients are resistant to conventional treatments. Schizophrenia, a chronic and severe psychiatric disorder, often presents with a combination of positive symptoms (such as hallucinations and delusions), negative symptoms (such as social withdrawal and emotional blunting), and cognitive impairments. While antipsychotic medications are the primary treatment, approximately 20–30% of individuals with schizophrenia do not …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 43–48 Read article