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15 articles for “Immunoglobulins”
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Subclinical Significant High Serum Immunoglobulin E Response to 20 Allergens: Age and Gender Based Study
Abstract: Background: Antigen-immunoglobulin E (IgE) reaction is an example of immediate allergic reactions. High serum IgE levels were reported in many diseases that linked to the multiple allergens. Objectives: This study aimed to measure the serum IgE against 20 allergens in patients who had a previous history of allergy due to unidentified precipitating factors. Methods: This retrospective study was conducted at the Al Zahraa Consultant Center for Allergy and Asthma that …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 3, 2019 · pp. 1–6 Read article
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Development of Anti IgG Polyclonal Antibody Against Canine IgG and Their Roles in Diagnostic Purposes
Abstract: IgG plays an important part in immunological studies and also in living bodies for providing secondary immune response which triggers as passive immunization against harmful pathogens in dogs. Purpose: The aim of this investigation is to separate, identify, and refine immunoglobulin G from canine serum. Methods: Ammonium sulphate precipitation was used to separate the dog's serum, which was then concentrated over night in a dialysis bag inside of a refrigerator. …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 01–06 Read article
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Infant’s Immunity w.s.r. to Compliment System: A General Review
Abstract: Infant’s mortality and morbidity rate in developing countries are at higher incidence due to infections. Various factors are responsible for infections, such as low socio-economic status, poor hospital facilities and malnutrition etc. The low level of compliment components and serum immunoglobulin in infants has been claimed to be the reason of defective opsonic activity in infants as well as defective generation of chemotaxis activity. Thus immune system during neonatal as …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 1–11 Read article
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An Overview of the Human Immune Response
Abstract: This overview of the immune response provides a glimpse of the complexity of the interactions between the cells and mediators of the immune system. The recognition of the innate immune response by microbes and foreign substances leads to the induction of inflammatory and adaptive immune response. when oxidative stress increases, it affects our vital processes such as glucose homeostasis, cellular life-span and inflammation, which contributes to the pathogenesis of many …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 46–62 Read article
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Immunologic Characteristics of Apparently Healthy Nigerians Exhibiting Abnormal SPE: A Preliminary Study
Abstract: Abnormal serum protein electrophoresis patterns have been discovered in apparently healthy Africans in Britain and Ghanaians living in Accra, Ghana. Conflicting reasons were suggested for this phenomenon. The aim of present study was to determine the prevalence and characteristics of serum protein electrophoresis (SPE) abnormalities in apparently healthy Nigerians living in Ogbomoso. Three hundred (300) apparently healthy subjects aged 20–30 years were selected for the study. SPE was performed on …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 1–6 Read article
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Alopecia Areata: Complex Roots and Potential Cures
Abstract: Autoimmunity is when the healthy organs of an individual’s body are attacked by its own immune system, leading to illness or functional abnormalities. The hair follicles (HFs) are wrongly destroyed by the immune system in a condition known as Alopecia Areata and results in chronic non-cicatricial hair loss discernible by spherical patches. It’s a severely worsening or relapsing malady that can be permanent during severe falling out of hair. In …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 41–54 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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Review: Virulence factors, resistance genes and pathogenicity of Moraxella catarrhalis
Abstract: An estimated 2-4 million cases of chronic obstructive pulmonary disease(COPD) in adults are exacerbated by Moraxella catarrhalis annually in the US, making it a pathogen of increasing significance for respiratory tract infections. It often colonizes the nasopharynx without causing any symptoms and an opportunistic bacterial infection of the respiratory mucosa that is exclusive to humans. In our study, we reviewed references about the important virulence factors that M. catarrhalis possess …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 33–40 Read article
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Human Milk and Infant Growth: A Systematic Review of Nutritional Outcomes
Abstract: Human milk is recognized as the optimal source of nutrition for infants, playing a critical role in their growth and development. This systematic review explores the evidence linking human milk consumption to various growth parameters in infants, including weight gain, length, and head circumference while considering the influencing factors of prematurity and health status. The composition of human milk, rich in essential macronutrients (proteins, fats, carbohydrates) and micronutrients (vitamins and …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–6 Read article
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Milk Allergy: Significance, Detection and Management
Abstract: Milk allergy is a significant public health issue, particularly among infants and young children, with prevalence rates between 2 and 6% in early childhood, declining to 0.1–0.5% in adulthood. It is an immune-mediated adverse reaction to milk proteins, primarily involving immunoglobulin E (IgE)-mediated responses. Symptoms range from gastrointestinal distress and respiratory complications to severe anaphylaxis. The etiology of milk allergy involves genetic predisposition, environmental factors, an immature immune system, and …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 1, 2025 · pp. 15–19 Read article
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Anaphylaxis: Pathophysiology, Risk Factors, and Clinical Management
Abstract: Anaphylaxis is a syndrome characterized by broncho-constriction, vasodilatation, and hypovolemia, potentially fatal exposure to known or unknown antigens. It can be an immune-mediated (IgE & non-IgE) disease. Immunoglobulin G (IgG), complement related (C3a/C5a), bradykinin, leukotrienes, prostaglandin E2, and ligands of certain G-protein coupled receptors (GPCR) can directly activate mast cells, basophils, eosinophils, neutrophils, endothelial cells and smooth muscles. Serum tryptase level during episodes of anaphylaxis, skin test, and basophil activation …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 · pp. 1–11 Read article
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Concept of Ojas with Relevancy of Physiological Properties
Abstract: In the human body, metabolic activity is performed by Tridosha (functional entity and vitiating substances), Sapta Dhatus (seven tissue levels) and Malas (waste products). In addition to this, Ojas is considered as Dhatu & the essence of all Dhatus, which is present in every compartment of the body. Its quality is homologous to Kapha (lubricating and protective substance). Strength and body protecting phenomenon are governed by certain substances. It lies …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 4, Issue 1, 2015 · pp. 30–38 Read article
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Mucosal Vaccines in Fish: Novel Advances in Technology and Delivery: A Review
Abstract: Vaccines rely on the acquired immune system and prime an animal to a particular antigen so that on subsequent encounter; it is recognized and quickly destroyed. The vast majority of pathogens enter the body via the mucosal surfaces of the gastrointestinal, respiratory, and urogenital tracts, where they initiate mucosal infections that lead to systemic infections. There is strong evidence that an optimum mucosal immune response can prevent systemic infection and …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 1, 2019 · pp. 14–26 Read article
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An Emerging Cause of Treatable Encephalitis: A Case of Anti-NMDA receptor (NMDAR) Encephalitis
Abstract: Anti-NMDA Receptor encephalitis is the most common type of autoimmune limbic encephalitis known. It is characterised by sub-acute onset of psychiatric symptoms along with refractory epilepsy, orofacial and limb dyskinesia and dysautonomia. High clinical suspicion and appropriate antibody testing in cerebrospinal fluid (CSF) and serum is required for early diagnosis and initiation of immunotherapy. Delay in treatment may lead to significant permanent neuro-deficits as well as mortality. Here, we present …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 3, 2017 · pp. 8–11 Read article