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14 articles for “Hub genes”
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Medical Tourism in India: Analyzing Benefits, Risks, and Regional Trends
Abstract: Background: India’s medical tourism industry has emerged as a global hub, generating approximately US$9 billion annually and attracting over 2 million patients seeking cost-effective, high-quality treatments and wellness therapies. Objective: To evaluate the benefits, risks, and regional disparities in medical tourism experiences among patients and providers across five Indian states. Methods: A mixed-methods study was conducted involving 850 international patients and 150 healthcare providers. Quantitative data were gathered through structured …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 12–16 Read article
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To Evaluate the Performance of the Selected Hybrid Systems and Validation of Mathematical Model with the Experimental Data
Abstract: The main aim of this paper to evaluate the performance of the PV-Wind hybrid systems and validation of mathematical model with the experimental model. In the research paper, the experimental model of PV-Wind Hybrid system has been installed at a height of 22 meters in the School of Energy and Environmental studies, DAVV, Indore, and M.P., India. The theoretical calculation of the wind generator output has also been compared with …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 16, Issue 2, 2025 · pp. 20–28 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Introduction to Biological Networks and their Contributions to Systems Biology
Abstract: Biological networks provide a conceptual framework to represent and analyze the intricate interconnections among the numerous components that make up living systems. This review paper elucidates the foundational principles of networks and their diverse applications in systems biology, highlighting their crucial role in understanding the inherent complexity of biological processes. Utilizing graph theory, these networks represent entities like genes, proteins, and metabolites as nodes, with their interactions depicted as edges. …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 53–70 Read article
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Unified Mass–Energy Dissolution Cosmology (UMEDC): A Staged Framework for Cosmic Energy Transformation and Late-Time Acceleration
Abstract: The ΛCDM model successfully describes the universe’s expansion but remains fundamentally descriptive: it assigns fixed densities to matter, dark matter, and dark energy without providing a unifying physical mechanism behind their coexistence or evolution. In this work, we introduce the Unified Mass–Energy Dissolution Cosmology (UMEDC), a novel framework based on the staged transformation M → DM → DE, where ordinary matter gradually dissolves into a dark-matter-like reservoir, which subsequently transforms …
Published in International Journal of Universe · Vol. 1, Issue 2, 2025 · pp. 18–34 Read article
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Semantic Network Technology and Digital Library
Abstract: In recent years, the volume of information available on the internet has grown rapidly, leading to the need for more effective ways to manage and access high-quality content. Much of this reliable and well-structured information is stored in digital libraries, which serve as centralized hubs for organized knowledge. However, despite their usefulness, managing and navigating these vast collections of data continues to present significant challenges. To address these issues, the …
Published in Current Trends in Information Technology · Vol. 15, Issue 2, 2025 · pp. 13–18 Read article
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Supervision of College Management Using Database Management System
Abstract: The college management system is a software application created with C programming and file handling methods. It serves as a centralized platform for overseeing diverse aspects of college operations, encompassing student details, course information, faculty records, enrollment management, attendance monitoring, grade administration, reporting, and administrative functions. It is designed to efficiently manage student, course, and faculty information in a college setting. The system utilizes files for data storage and conducts …
Published in Journal of Advanced Database Management & Systems · Vol. 11, Issue 2, 2024 · pp. 1–7 Read article
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Micro Level Mobility Intervention in Urban Spatial Structure in Reducing GHG Emissions: A Case of The City of Lucknow, Prayagraj and Varanasi
Abstract: In contemporary times, the Greenhouse Effect has emerged as a paramount concern in urban areas. With India undergoing rapid urbanization, cities are witnessing soaring temperatures. Greenhouse gas emissions are one of the main causes of the Greenhouse Effect. India stands among the highest emitters of GHGs, primarily stemming from the energy sector, particularly in electricity generation. The period from 2005 to 2018 saw a noteworthy surge in India's emissions, largely …
Published in Trends in Transport Engineering and Applications · Vol. 12, Issue 3, 2025 · pp. 25–33 Read article
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Supply Chain Design Considering Social and Environmental Risks
Abstract: The aim of the research is to design a supply chain taking into account social and environmental risks. In this research, an attempt was made to present a model that, by considering variables close to the real world, simultaneously considers cost and sustainability issues for designing a meat supply chain network, including locating facilities, using technology in them, how products flow in the network, etc. In order to examine the …
Published in International Journal of Industrial and Product Design Engineering · Vol. 4, Issue 1, 2026 · pp. 35–43 Read article
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Universal Immunization Program in India
Abstract: The Universal Immunization Program (UIP) in India, initiated by the Government of India in 1985 and incorporated into the Child Survival and Safe Motherhood Program in 1992, plays a crucial role in enhancing public health through systematic vaccination efforts. This program aims to save lives and strengthen immune systems by administering vaccines and antibiotics. The UIP has spurred the development of various campaigns, including mass media efforts, to promote immunization …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 24–30 Read article
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E-Empire: Brake & Acceleration In E-Cycle
Abstract: As e-cycles continue to gain momentum as an eco-friendly and efficient mode of transportation, understanding their key mechanical and electronic systems becomes even more vital. The report delves deeply into the nuances of braking mechanisms and acceleration technologies, emphasizing their roles in enhancing both safety and performance. By comparing mechanical disc brakes with hydraulic systems, it highlights the distinct advantages of each. For instance, hydraulic brakes, known for their superior …
Published in Journal of Automobile Engineering and Applications · Vol. 11, Issue 3, 2024 Read article