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5 articles for “Heterocyclic nucleus 1”
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Progress in Pharmacological Potential of Thione Substituted 1,3,4-Thiadiazoles: A Review
Abstract: Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. From the last decade, good research is going on the 1,3,4-thiadiazole ring, as a result of which, many research groups has developed novel clinically useful compounds. These compounds had shown its importance as anti-inflammatory, analgesic, antimicrobial, antitumor, antifungal, antimycobacterial, anticonvulsant, antidiabetic, antiviral agents etc. So far, the modifications of the 1,3,4-thiadiazole ring has proven highly effective way …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 2, 2012 · pp. 9–34 Read article
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1,2,3,4-Tetrahydroquinoline: A Versatile Nucleus in the New Millennium
Abstract: Tetrahydroquinoline nucleus containing molecules are well known for their presence in natural products mainly in alkaloids, which constitute the active class of compounds possessing wide spectrum of biological activities. Tetrahydroquinoline skeleton is often used for the design of several synthetic compounds with diverse pharmacological properties. An immense wide range of pharmacological utility of such nucleus has inspired many synthetic and medicinal chemists to develop novel strategies for their synthesis, which …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 1–18 Read article
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A Review on Anti-Inflammatory Activity of Benzthiazole Derivatives
Abstract: Benzothiazoles are an important biologically active heterocyclic compounds which contain six membered benzene rings fused with five membered thiazole rings at 1,4 positions. They possess various biological activities like Anti-microbial, Anti-fungal, Anthelmintic, Antioxidant and Anti-inflammatory activities. Benzothiazoles nucleus is believed to produce it’s Anti-inflammatory activity either by inhibiting Beta-2 receptors of Bradykinin or by inhibiting cox₂ enzymes (cyclooxygenase). The present review focuses on some methods of benzothiazoles synthesis and its …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 1, 2022 · pp. 1–13 Read article
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Chompound contaning oxadiazole derivatives and their potential therapeutic uses.
Abstract: Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring's aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 68–74 Read article
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Design, Synthesis and Pharmacological Evaluation of Pyrazoline Substituted Benzimidazole Derivatives as Antibacterial and Antifungal Agents
Abstract: Background: Benzimidazoles are important heterocyclic compounds possessing a variety of biological activities such as anticancer, antioxidant, antiinflammatory, analgesic, anti-viral, anti-bacterial, anti-fungal and hypoglycemic activities. Pyrazolines are used as antitumor, immunosuppressive, antibacterial and anti tubercular agents. Aim : The present research focused on incorporating pyrazoline nucleus into benzimidazole nucleus to form a potent antibacterial and antifungal agent. Method: The in silico design of novel pyrazoline substituted benzimidazole derivatives was done using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 29–41 Read article