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13 articles for “Fab stability”
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Self-Healing Thin Films: Paving the Way for Smart, and Sustainable Corrosion Protection
Abstract: Corrosion is one of the serious problems that industries and infrastructures of every type face, ranked among such threats as huge economic losses and concerns to global safety. Recent developments in the area of self-healing thin films make them a really promising innovation for enhancing corrosion protection. This review considers the development, mechanisms, and applications of self-healing thin films. Detailed here are intrinsic and extrinsic self-healing strategies oriented toward chemical …
Published in International Journal of Crystalline Materials · Vol. 2, Issue 1, 2025 · pp. 22–45 Read article
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Advanced Solid-State Battery Technologies for Sustainable Energy Storage
Abstract: The increasing global demand for sustainable and high-performance energy storage systems has accelerated research in advanced battery technologies. Conventional lithium-ion batteries, while widely used in portable electronics, electric vehicles, and grid storage systems, face limitations such as safety risks, limited energy density, slow charging rates, and degradation over repeated cycles. To overcome these challenges, advanced solid-state battery technologies have emerged as a promising solution for next-generation energy storage applications. This …
Published in International Journal of Solid State Innovations & Research · Vol. 4, Issue 1, 2026 Read article
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Next-Generation Membrane Materials: Advances, Applications, and Challenges
Abstract: Advanced membrane materials are better than regular polymers because they are more selective, permeable, and stable. New developments in nanomaterials, composite membranes, and surface engineering are making it possible to do more with water purification, gas separation, biomedical applications, and energy systems. Membrane technologies have become important tools in many areas, including biomedicine, energy systems, gas separation, and water purification. Recent progress in material science has made it possible to …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 19–28 Read article
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Biopolymer-Based Nanoparticles: Advances in Fabrication, Characterization, and Biomedical Applications
Abstract: The emergence of biopolymer-based nanoparticles, particularly those composed of proteins and polysaccharides, has significantly transformed the landscape of biocompatible and biodegradable materials. These nanoparticles offer immense potential due to their ability to facilitate encapsulation and targeted delivery of bioactive compounds, enhancing therapeutic efficacy while minimizing side effects. This review explores the various fabrication techniques, including emulsification, desolvation, coacervation, and electrospray drying, emphasizing their advantages and limitations. The characterization of nanoparticles …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 1, 2025 · pp. 38–46 Read article
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A Sol-Gel Approach for the Fabrication of Zinc Oxide Nanoparticles and Their Nanocomposite with Urea Formaldehyde (UF)
Abstract: In the performed work, zinc oxide nanoparticles were synthesized via the sol-gel method using zinc sulphate as the precursor material. Urea-formaldehyde (UF) resin was employed as a polymer matrix to encapsulate the produced ZnO through an acid-catalyzed polymerization process. This encapsulation aimed to improve the dispersion stability and surface reactivity of ZnO within the polymeric medium. The synthesized materials were subjected to comprehensive characterization using Fourier Transform Infrared Spectroscopy (FT-IR), …
Published in International Journal of Crystalline Materials · Vol. 2, Issue 2, 2025 · pp. 21–27 Read article
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Innovative Approaches in Bioinspired and Biomimetic Membrane Technologies: Bridging Nature and Engineering
Abstract: Bioinspired and biomimetic membranes represent a ground breaking advancement in membrane technology, offering innovative solutions to critical global challenges in water purification, chemical separation, and energy conversion. These membranes leverage the exceptional transport properties of biological systems, particularly through the incorporation of aquaporin proteins, which facilitate rapid and selective water transport. This review synthesises recent developments in aquaporin-based membranes, highlighting their remarkable efficiency in desalination processes, where they serve as …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 53–60 Read article
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Advancements in Nanostructured Membranes for Gas Separation: A Comprehensive Review
Abstract: Gas separation is vital in petrochemical, pharmaceutical, and environmental industries, yet traditional methods like distillation and cryogenic separation are energy-intensive and inefficient. Nanostructured membranes present a promising alternative, utilizing nanomaterials such as titanium dioxide, silica, carbon nanotubes, zeolite, and metal-organic frameworks to enhance separation efficiency and selectivity while reducing energy consumption. These membranes fall into various categories: polymeric nanostructured membranes, including mixed matrix and thin-film composites; inorganic membranes, such as …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 31–36 Read article
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Development of 3D Printing Filaments from Industrial Waste Plastics
Abstract: The global plastic waste crisis has prompted innovative approaches to sustainable material reuse, particularly in additive manufacturing. Simultaneously, the accumulation of plastic waste presents significant environmental concerns. Recycling plastic into filament supports eco-friendly innovation and brings us closer to a circular economy where materials are reused instead of thrown away. This study investigates the development of 3D printing filaments from industrial waste plastics, including polypropylene (PP), acrylonitrile butadiene styrene (ABS), …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 12–17 Read article
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Advances in Membrane Technology: A Comprehensive Review of Materials, Processes, and Applications
Abstract: Membrane technology has become a critical platform for sustainable separation processes across water treatment, energy generation, chemical processing, and healthcare. Over recent decades, advances in materials, fabrication methods, and process design have dramatically expanded the performance, efficiency, and applications of membrane-based systems. Polymeric membranes dominate the industry due to cost-effectiveness and scalability, while ceramic, metallic, and composite membranes offer enhanced thermal and chemical resistance for specialized environments. Nanostructured and bio-inspired …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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Enhancing Functional and Structural Properties of Advanced Materials through Scandium-based Nanostructures: Applications in Ceramics, Thermoelectrics, Memory Devices, and High-Strength Alloys
Abstract: This study explores the fabrication and properties of scandium-based nanostructured materials with applications in ceramics, glass, thermoelectric modules, switching devices, and strengthened alloys. Scandium oxide (Sc₂O₃) nanopowders were synthesized using precipitation techniques and subsequently sintered to create transparent ceramics with fine dispersion. Investigations into scandium-doped metallic glasses demonstrated enhanced plastic deformation, with notable tensile plasticity attributed to its unique nanoglass structure. A new scandium-doped thermoelectric material, ZnCdO, was also developed, …
Published in International Journal of Minerals · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Hybrid Material Systems for Flexible Electronics Electro-Mechanical Performance and Future Prospects
Abstract: Flexible electronics are transforming the landscape of modern electronic systems, enabling devices that are lightweight, stretchable, and adaptable to complex surfaces. These technologies are particularly impactful in applications such as wearable health monitors, soft robotics, energy harvesting systems, and implantable biomedical devices. At the heart of this evolution are hybrid material systems—engineered composites that combine organic polymers and inorganic nanomaterials to achieve synergistic electro-mechanical properties. These materials address the limitations …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 7–12 Read article
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Comparison Analysis of Transformer Boosting and Induced Degeneration Topology Design of LNA for Millimeter Wave Frequency Range Using Polymeric Substrates
Abstract: In this study, a comparison between transformer boosting and source degeneration LNA topologies is conducted using two polymeric substrates—Polyimide (PI) and Liquid Crystal Polymer (LCP)—for millimeter-wave (mmWave) applications. With growing interest in flexible and high-frequency electronics, polymeric materials offer unique advantages such as low dielectric constants, mechanical flexibility, and thermal stability. The analysis explores gain, return loss, and noise figure performance while evaluating the influence of dielectric properties on the …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 3, Issue 2, 2025 · pp. 1–24 Read article