Search
44 articles for “ESCAP”
-
Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article
-
Beyond Chemotherapy: The Promise of Immunotherapy in Cancer Care and Advancements in Cancer Therapy
Abstract: Recent advances in cancer immunotherapy harness the immune system to precisely target cancer. These include the use of immunosuppressive agents, NK cell recovery, changes in tumor microenvironment metabolic, and aging to achieve a positive tumor response The article explores how the body development of the immune system in the late 19th century, highlighting milestones such as the discovery and FDA approval of IL2. Different categories of immunology are explored, from …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 2, 2023 · pp. 22–37 Read article
-
Fast Recovery and Privacy Preservation against Global Eavesdropper in Ethernet Network
Abstract: Fast recovery from link failures is a well-studied topic in IP networks. Employing fast recovery in Ethernet networks is complicated as the forwarding is based on destination MAC addresses, which do not have the hierarchical nature similar to those exhibited in Layer 3 in the form of IP-prefixes. Moreover, switches employ backward learning to populate theforwarding table entries. Thus, any fast recovery mechanism in Ethernet networks must be based on …
Published in Journal of Advances in Shell Programming · Vol. 3, Issue 1, 2016 · pp. 12–18 Read article
-
Stress: The Negative Modulator of NGF
Abstract: Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Depression is associated with deficiencies in mono-aminergic transmitters and possibly neurotrophins. Stress-induced helplessness in rodents constitutes a well defined model to investigate neurobiological mechanisms of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 1, Issue 2, 2011 · pp. 1–7 Read article
-
A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
-
Effect of Chronic Inescapable Footshock and Antidepressant Treatment on BDNF/TrkB Levels in Rat Hippocampus
Abstract: Depression is a major health problem globally. Chronic stress arising out of life style or social factors may trigger depression, the molecular basis of which has been attributed to alterations of brain chemicals like neurotrophins. Among these neurotrophins, brain-derived neurotrophic factor regulates many physiological functions in the brain, alteration of which has been well associated with the pathogenesis of depression. Stress-induced helplessness in rodents constitutes a well-defined model to investigate …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 12–21 Read article
-
Water Stress: An Overview on Plant Life
Abstract: AbstractPlant water status determines the tolerance and escapability of a plant towards the drought or other stress. There are morphological, physiological and biochemical significance of the drought. Plants have the drought tolerance capability by changing its physiology and biochemical compounds. The accumulation or relocation of the bio compounds determines the stress tolarance capacity and those compounds are called stress tolerance compounds. In normal they are the middle or end product …
Published in Research & Reviews : Journal of Ecology · Vol. 3, Issue 3, 2014 · pp. 12–26 Read article
-
Jayant Mahapatra’s India: A Mirage of Social Introspection
Abstract: Indian English Literature is a mixture of Indian sensibility and Indian culture on one side and Western language on the other side. Indian English writers from different time frames have variedly injected the socio-political and cultural components in their literary works as it is said that literature mirrors society and can serve as a social document. No writer can escape from the race, milieu, and moment in which he or …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 2, 2024 · pp. 51–54 Read article
-
Coming of Age in Nature: An Ecocritical Reading of Ruskin Bond’s The Room on the Roof
Abstract: This research paper explores the human-nature relationship in Ruskin Bond's classic novel, "The Room on the Roof," through the lens of ecocriticism. Ecocriticism, a critical theory examining literature's portrayal of the environment, provides a valuable framework for analyzing the novel's themes of escape, self-discovery, and the impact of human actions on the natural world. The paper analyzes the novel, demonstrating how Bond utilizes ecocriticism to depict the transformative power of …
Published in International Journal of Trends in Humanities · Vol. 1, Issue 1, 2024 · pp. 13–17 Read article
-
Optimal Dosage of Pumice in Lightweight Aggregate based Conc
Abstract: Lightweight concrete (LWC) is a pioneering solution in the construction sector, characterized by its unique composition and versatile applications. Engineered with lightweight aggregates and additives, LWC achieves a significant reduction in dry density compared to conventional concrete, making it 23% to 87% lighter, with densities ranging from 300 to 1,840 kg/m³. This reduced weight makes LWC ideal for projects requiring load minimization, such as high-rise buildings and prefabricated elements. A …
Published in International Journal of Minerals · Vol. 1, Issue 1, 2024 · pp. 23–32 Read article
-
SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article
-
Virulence Factors in pathogens :mechanisms of infection & disease progression
Abstract: Pathogens, like bacteria, viruses, fungi, and parasites, have evolved specialized tools – known as virulence factors – that help them infect hosts, escape the immune system, and cause disease. These factors play a key role in determining how severe an infection becomes, how quickly it spreads, and how the body responds. Some pathogens use adhesins to stick to host cells, while others produce toxins that damage tissues or disrupt normal …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 6–11 Read article
-
Fraud Detection in Government Procurement Using Machine Learning
Abstract: Fraud represents a significant challenge in the realm of procurement, with estimates indicating that between 12 and 30% of global procurement budgets are lost to fraudulent activities (OECD, 2023). The pervasive nature of procurement fraud, which may encompass a range of deceptive practices such as bid rigging, invoice fraud, and procurement kickbacks, not only undermines the integrity of financial operations but also results in substantial losses for organizations. These losses …
Published in Journal of Open Source Developments · Vol. 12, Issue 2, 2025 · pp. 19–34 Read article
-
Host-Pathogen Coevolution: Implications for Immune Evasion and Pathogen Fitness
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 6–10 Read article
-
Revolutionizing Vaccine Development:The Transformative Role of Bioinformatics in Designing Next-Generation Immunotherapies
Abstract: Vaccines have long been central to the prevention and control of infectious diseases, dramatically reducing morbidity and mortality worldwide. In the modern era, the integration of bioinformatics has revolutionized vaccine development by enabling rapid, precise, and cost-effective identification of potential vaccine targets. This seminar explores the multifaceted applications of bioinformatics in vaccinology, including antigen discovery, epitope prediction, structural modeling, molecular docking, and immunoinformatics-driven vaccine design. Special emphasis is placed on …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 19–33 Read article
-
Managing Blow-by in Modern Engines: A Comprehensive Review of Crankcase Ventilation Technologies
Abstract: Blow-by in internal combustion (IC) engines occurs when high-pressure combustion gases escape past the piston rings into the crankcase. These gases typically carry oil aerosols, unburned hydrocarbons, and fine particulate matter, which, if not effectively managed, can disrupt lubrication, accelerate component wear, and contribute to harmful emissions. Effective crankcase ventilation is therefore essential not only for ensuring engine durability but also for meeting increasingly stringent emission regulations. This paper examines …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 317–324 Read article
-
Fire Safety in Healthcare Facilities: An Indian Perspective
Abstract: Fire protection and safety measures in hospitals are of utmost importance to ensure the safety of patients, staff, and visitors. Due to the patients' limited mobility, hospitals are more susceptible to fire disasters. Short-circuits, basements being used as storehouse, inappropriate storage of flammable liquids, improper power supply load, false ceiling panel lined with thermocol, faulty electric wirings, and overheating leading to burning of wires are some of the common causes …
Published in Journal of Industrial Safety Engineering · Vol. 13, Issue 1, 2026 · pp. 8–12 Read article
-
Design and Development of Onion Storage Shade for Better Ventilation and Longer Life
Abstract: Onions are one of the most important cash crops for farmers in India and many other countries. However, most harvested onions are lost every year due to improper storage. Traditional storage methods, such as keeping onions in heaps under trees, in closed rooms, or in poorly ventilated sheds, do not provide sufficient airflow. As a result, moisture accumulates, leading to sprouting, fungal growth, rotting, and physical damage. These losses reduce …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 1, 2026 · pp. 31–41 Read article
-
Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 Read article
-
Development of Polymersomes as Macromolecular Platforms for Nanomedicine
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymersomes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2–50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows predictability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 71–89 Read article