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6 articles for “Chromene”
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An Efficient Synthesis of Some Novel Benzo Coumarin Derivatives Under Solvent Conditions from 2-acetyl-benzo[f]chromen-3-one
Abstract: The synthesis of the target compounds began with the preparation of 2-[3-dimethylamino[acryloyl-3H-benzo[f]chromen-3-one. This intermediate was obtained through the reaction of 2-acetylbenzo[f]coumarin-3-one with N,N-dimethylformamide dimethyl acetal [DMFDMA[ under reflux conditions in xylene. The enaminone thus formed was subsequently reacted with 6-aminothiouracil in acetic acid, leading to the formation of 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one. This compound served as a pivotal intermediate for the synthesis of a series of pyridotriazolopyrimidinones. These derivatives were synthesized by reacting …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 33–46 Read article
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Emerging Therapeutic Discovery Against Escherichia coli Infection by Rational Inhibition of Fatty Acid Responsive Transcription Factor: Theoretical Molecular Investigations of Some Metabolites as Inhibitors of Fatty Acid Metabolism Protein
Abstract: For the discovery of effective agent for overcoming resistance against Escherichia coli (E. coli) bacteria by modulating Fatty Acid Metabolism Protein (FadR)—a Fatty Acid Responsive Transcription Factor. The present study involved discovery of some metabolites of furan, furan-2-yl, macrolactin, and chromene scaffold via in silico structure-based drug design (SBDD) technique by utilizing the Maestro 9.1 software. The study will provide clues, motivate, and throw light on imperative aspects for the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 1–7 Read article
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Synthesis of new heterocyclic compounds containing nitrogen, sulphur and study their biological activity
Abstract: Several substituted pyridines with brominated coumarin and with other substituents were achieved by condensing brominated coumarin IV with 4-methoxybenzaldehyde in basic solution forming α,β-unsaturated ketone II. Hantzsch reaction of this ketone with β-ketoester to provide precursor substituted pyridines. The Hantzsch reaction product was subjected to different reactions. The other targeted heterocyclic compound was obtained by reaction of α,β-unsaturated ketone II with hydrazine carbothioamide to give substituted pyrazole with brominated coumarin, …
Published in Emerging Trends in Chemical Engineering · Vol. 8, Issue 3, 2021 · pp. 8–16 Read article
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PHD-2 Activation to Stabilize HIF-1α and FASN in Mammary Gland Cancer
Abstract: Activation of prolyl hydroxylase-2 (PHD2) has emerged as an attractive target to counteract tumor hypoxia and thereby uncontrolled cellular proliferation. We utilized an integrated strategy to identify new PHD2 activators using series of in silico tools and in vitro methods. The in silico screening helped to identify 4-ethyl-3-(4-methoxyphenyl)-2,2-dimethyl-2H-chromen-7-yl acetate (BBAP-3), [4-(7-acetyloxy-4-ethyl-2,2-dimethylchromen-3-yl)phenyl]acetate (BBAP-4), 3-(4-methoxyphenyl)-2,2,4-trimethyl-2H-chromen-7-yl acetate (BBAP-5) as an activator, who are structurally similar to KRH102140 (a known activator of PHD2). All …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 28–33 Read article
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Synthesis and Evaluation of New Coumarin Derivatives for Inflammatory Bowel Disease Against DSS-Induced Acute Ulcerative Colitis Mice Model
Abstract: Objective: The discovery of the now numerous mouse models of intestinal inflammation has increased our understanding of the intestinal inflammation that occurs in inflammatory bowel disorders (IBD). This study aimed to investigate the use of a standardized animal model subjected to coumarin derivative treatment, and the action of synthesized molecule administration of dextran sodium sulphate (DSS)- induced colitis in experimental mice. Materials and Methods: We generated a variety of unique …
Published in Journal of Modern Chemistry & Chemical Technology Read article
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Domino Reaction for the Synthesis of Nitroolefin Heterocyclic Compound Via Thiazole Formation Followed by Claisen Rearrangement
Abstract: The Baylis-Hillman adducts derived from nitroolefins have been conveniently transformed into Claisen rearrangement. These substances, which include benzothiazole moiety, are very biologically reactive substances. This novel nitro derivative of 2-((E)-2-nitro-3-phenylallyloxy)-3-ethoxybenzaldehyde was simply treated with mole percentage of 2-(2-(2-aminophenyl) disulfanyl) benzenamine in melt reactive condition. Hence this novel 2-(benzo[d]thiazol-2-yl)-6-ethoxy-4-((E)-2-nitro-3-phenylallyl)phenol core unit compounds was very intrusting and new opportunities for the preparation of closely related to the different [3,3] sigmatropic rearrangements related …
Published in Journal of Modern Chemistry & Chemical Technology Read article