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93 articles for “Carcinogen”
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Impact of Groundwater Pollution on Carcinogenic and Non-Carcinogenic Health Effects: A Review
Abstract: Groundwater is a critical source of drinking water in many regions worldwide, particularly in South and Southeast Asia, where dependence on untreated groundwater remains high. However, increasing groundwater contamination poses serious risks to human health. This review synthesizes recent peer-reviewed studies to examine the sources, distribution, and health impacts of major groundwater contaminants, with a focus on both carcinogenic and non-carcinogenic risks. Emphasis is placed on fluoride, nitrate, chromium, and …
Published in Research & Reviews : Journal of Ecology · Vol. 15, Issue 1, 2026 · pp. 40–46 Read article
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Arsenic Contamination in Groundwater of the Majha Belt of Punjab, India, and its Probable Carcinogenic and Non-Carcinogenic Health Hazards
Abstract: Arsenic is widespread in India. Majha belt of Punjab State, comprising districts of Amritsar, Gurdaspur and Tarn Taran, is reported facing a crisis situation due to high levels of arsenic in its groundwater. ICAR (Indian Council of Agricultural Research) has reported arsenic beyond safe limit in 13 districts of Punjab. Sample analysis was done using standard protocol in the sophisticated laboratory of DWSS (Department of Water Supply and Sanitation) in …
Published in Journal of Water Pollution & Purification Research · Vol. 10, Issue 2, 2023 · pp. 106–132 Read article
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Environment, Health, and Carcinogenic Concerns in the Light of Microvita Theory
Abstract: This study examines the relationship between environmental health, carcinogenic risks, and P.R. Sarkar’s microvita theory, introduced in 1986. Microvita are described as subtle entities that influence both physical and mental realms, potentially interacting with environmental factors and playing a role in health and disease, particularly in the process of carcinogenesis. By merging this philosophical concept with modern scientific insights, the study offers a fresh perspective on addressing environmental hazards that …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 15, Issue 2, 2025 · pp. 8–18 Read article
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Cellular Mechanisms of Autophagy in Carcinogenesis: A Narrative Review
Abstract: Autophagy is a highly conserved lysosomal degradation pathway essential for cellular homeostasis, metabolic adaptation, and survival under stress. In the context of carcinogenesis, autophagy exhibits a paradoxical and stage-dependent role. During early tumor development, autophagy acts as a tumor-suppressive mechanism by limiting genomic instability, oxidative stress, and chronic inflammation. Conversely, in established malignancies, cancer cells exploit autophagy to sustain growth, survive hostile tumor microenvironments, and resist anticancer therapies. Increasing evidence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 23–28 Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Nitrosamine: The Carcinogenic Impurity in Angiotensin Receptor Blockers
Abstract: Angiotensin II Receptor Blockers (ARBs), commonly known as the Sartans, are used in the treatment of hypertension for a long time. Currently, seven Sartan drugs, i.e. Valsartan, Losartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, and Eprosartan, are in use. Recently, Nitroso impurity was detected in Valsartan active pharmaceutical ingredient, which led to the recall of batches of products containing it. Even in trace amounts, the impurity is said to be a probable …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 36–43 Read article
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Sources, Levels and Carcinogenic Potential of Polyaromatic Hydrocarbons in the Environment: A Short Review
Abstract: Polyaromatic hydrocarbons (PAHs) are the organic compounds that constitute a class of aromatic hydrocarbons known to be cancer causing agents. In the recent years an increased attention towards their sources and levels in the environments has been observed, mainly because of the elevated levels of some highly carcinogenic or mutagenic PAHs. The US Environmental Protection Agency (EPA) has recognized 16 PAHs (EPA-PAH) as priority pollutants. Eight from these 16 PAHs …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 3, 2019 · pp. 46–52 Read article
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Paradigm Shift of Hair Dye Use from Natural to Synthetic: A Concern for Carcinogenic Trigger
Abstract: More than 60% of the young population in different parts of the world use synthetic hair dyes to enhance their looks. People prefer to use synthetic formulations over natural ones. Synthetic hair dyes consist of potentially toxic and mutagenic chemicals depending upon the class they belong to. These chemicals interact with each other to form pigment molecules. Most of the hair dyes contain aromatic amines and its derivatives to produce …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 3, 2021 · pp. 15–22 Read article
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Betel Quid without Tobacco: A Threat to Oral Health and Well-being in India
Abstract: Betel quid without tobacco, a popular cultural product across India and other South and Southeast Asian nations, is often consumed for its refreshing stimulant effects during social and religious gatherings. Despite its deep cultural significance, the health hazards of betel quid – especially its strong association with oral cancers – are often overlooked. The International Agency for Research on Cancer (IARC) has identified betel quid as a human carcinogen, and …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 6–16 Read article
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The implementation of the food quality protection act (FQPA) in increasing the safety standards for new pesticides used on foods
Abstract: This paper examines the Food Quality Protection Act (FQPA) and its impact on enhancing safety standards for pesticides used on food in the United States. Initially, the study explores the Delaney Clause—a strict standard prohibiting carcinogenic food additives—which FQPA replaced with a more flexible "reasonable certainty of no harm" criterion. This shift allows the Environmental Protection Agency (EPA) to assess pesticide risk with consideration of potential benefits, even if a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 41–51 Read article
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Role of Food Supplements in Premalignant Lesions: A Literature Review
Abstract: Premalignant lesions of the oral cavity are histopathological alterations in the oral epithelium linked to a higher likelihood of malignant transformation. These lesions frequently present as leukoplakia (white patches), erythroplakia (red patches), oral lichen planus, and oral submucous fibrosis. Oral cancer, categorized among head and neck malignancies, is considered the sixth most common cancer globally. While tobacco and alcohol consumption remain the primary etiological factors, increasing evidence underscores the significant …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 17–26 Read article
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Assessment of Human Health Risk Factors Associated with Using Portable Water from the River Benue at Makurdi
Abstract: The non-carcinogenic and carcinogenic risk posed to children and adults by Cadmium, Nickel, Zinc and Lead concentration in River Benue water were evaluated in this study. Sampling for the metals was conducted on three locations in transect of north bank, middle stream and south bank making a total of nine stations. These metals were estimated as hazard index (HI) which took into account the combined effects from the heavy metals …
Published in Journal of Water Pollution & Purification Research · Vol. 8, Issue 3, 2021 · pp. 1–10 Read article
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Pattern of Cancer in Punjab (Cancer Capital of India)
Abstract: The problems of the nature and possible treatment of malignant disease are studied in many laboratories and results are published in different journals. It is difficult for any worker to keep in touch with all the published work. Excellent summaries of papers were published for many years in the Cancer Review, the publication of which was unfortunately suspended about ten years ago. Since then abstracts have been available in the …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 11, Issue 2, 2021 · pp. 4–11 Read article
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Assessing the Risk of Working with Chemicals in an Automotive Unit
Abstract: Today's human life is mixed with chemicals that can affect human health independently or independently. Also, many occupational diseases are caused by chemicals. Prevention of occupational diseases caused by exposure to life chemicals It saves people and improves the quality of life of other workers. The purpose of this study is to know the risks caused by chemicals, to evaluate It is the risk of hazards and the proposal of …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 36–42 Read article
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Parameters of “Safety” in the Food Additive Industry: A Review of Risks and Benefits
Abstract: “Safety is in the eye of the beholder.” What is deemed “safe” by one observer may seem dangerous or risky to others. To approach this apparent quandary and assure ongoing scientific input, most food additives should be tested on laboratory animals and subsequently monitored if approved for human or animal consumption (i.e., parallel to the pathway for the approval of drugs). The term “safety” in the study of the toxicology …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 2, 2015 · pp. 7–13 Read article
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Environmental estrogens: A silent enemy
Abstract: Throughout our lives we are exposed to environmental estrogens, from food, air, water, soil, and household products as well as probably through breast milk or during development in the womb. Environmental estrogens have endocrine disrupting activity. Many times natural plant compounds or synthetic chemicals may also disturb the endocrine system. These compounds are weaker than the estrogen naturally produced in the body. Many reproductive, developmental and other health problems have …
Published in Research & Reviews : Journal of Ecology · Vol. 10, Issue 3, 2021 · pp. 22–26 Read article
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Occupational Hepatocellular carcinoma : A review
Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. The relationship between occupation and liver cancer has not been extensively studied however. Approximately 80% of HCC patients have had an established history of chronic liver disease and infection with hepatitis B virus (HBV) and hepatitis C virus (HCV). Nonalcoholic steatohepatitis (NASH), obesity, diabetes and smoking also increase the risk of HCC development significantly. Currently, only vinyl chloride monomer …
Published in Research and Reviews: A Journal of Medicine · Vol. 1, Issue 1, 2011 · pp. 98–106 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Assess the Knowledge Regarding Usage of Plastic Leading to Cancer Risk and Their Preventive Measures Among House Wives in Selected Area Vaniyamkulam
Abstract: This study explores the level of awareness among housewives in Vaniyamkulam about the potential cancer risks associated with the use of plastic materials in households, along with their knowledge of preventive measures. The proliferation of plastic usage in daily life has raised significant health concerns, particularly its potential to release carcinogenic compounds such as bisphenol A and dioxins, which can leach into food and beverages. Given the critical role housewives …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 12–17 Read article
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Exploring the Genetic and Environmental Factors Contributing to Ovarian Cancer in Women in Mumbai, India
Abstract: Background: Ovarian cancer incidence in Mumbai has risen by 30% over the past decade, with an age-standardized rate of 9.1 per 100,000 women, contrasting stable trends in Western nations. This study investigates the interplay of genetic and environmental factors driving this disparity in Mumbai’s diverse population. Methods: A hospital-based case-control study was conducted at a hospital, enrolling 200 epithelial ovarian cancer cases (aged 30–70 years) and 400 age-matched controls. Germline …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 12–17 Read article