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22 articles for “Breast carcinoma”
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Role of Transcription factor AP-1 in Breast carcinoma
Abstract: Breast cancer is a major health problem of today. Transcription factor is nothing but protein that is needed for transcription. Activator protein-1 (AP-1) is a transcription factor of complex oncogene proteins (Jun and Fos). Fos and Jun family participate in many cellular processes which includes proliferation, differentiation and carcinogenesis. Therefore, this study has been designed to study level of transcription factor AP-1 in breast carcinoma. The study was carried on …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 2, 2019 · pp. 22–28 Read article
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Role of Nitric Oxide in Platelets of Breast Carcinoma
Abstract: Breast cancer is a disease of multifactorial origin; it is seen frequently in women of older age, having family history, affluent society, late age of marriage and first childbirth, early menarche, late menopause, and nulliparity. Oxidative stress results when balance between reactive oxygen species (ROS) production and antioxidant defence is lost which result in mutations, sister chromatid exchanges, cytotoxicity, carcinogenesis etc. Clinical, experimental and epidemiological studies suggest that free radicals …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 2, 2019 · pp. 25–29 Read article
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Metastasis of Lobular Breast Carcinoma to Cervix: A Case Report
Abstract: In India breast cancer is a very common malignancy. About 1 in 22 Indian women will develop invasive breast cancer during their lifetime. The incidence in US is 1 in 8 women. Increased incidence can be attributed to lifestyle. Among the two major subtypes of carcinoma breast lobular cancer is rare. Common sites of metastasis are lung, liver, bone, brain. Metastasis of lobular carcinoma to cervix is a very uncommon …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 2, 2016 · pp. 11–14 Read article
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Nitric Oxide—An Important Biomolecule in Breast Carcinoma
Abstract: Breast cancer represents significant problem of the world. Reactive nitrogen species of which nitric oxide (NO) is important constituent is a free radical gas which is synthesized by nitric oxide synthase (NOS).NO inhibits DNA synthesis and can damage DNA directly by deamination. In this study, NO level was studied in normal, pre- and postoperative cases of breast carcinoma. For this blood samples from 60 breast carcinoma cases were taken along …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 55–59 Read article
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Role of Nitric Oxide Synthase in Platelets of Breast Carcinoma
Abstract: Breast cancer is the leading problem of the world. Free radicals have unpaired electron which can be neutralised by human body for maintaining health, these free radicals are toxic, highly unstable and very reactive. Antioxidants and free radical scavengers protect cells from toxic effects in order to maintain redox state of the cell. Nitric oxide is one of the important free radicals synthesized from nitric oxide synthase. It has been …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 1, 2019 · pp. 36–39 Read article
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Correlation of Ki-67 Score with Nottingham Histological Grading in Carcinoma Breast: A Single Institution Experience
Abstract: Though it is reasonably well established that Ki-67 positivity is an independent predictor of ultimate prognosis and course of carcinoma breast and its recurrence, many lacunae exist. Ki -67 score correlation with histological grading will establish importance of nuclear antigen Ki-67 as prognostic factor in Indian population. This study was aimed to assess histological grading of breast carcinoma by Nottingham Grading System (Modified Scarff- Bloom- Richardson system) and to correlate …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 1, 2017 · pp. 1–5 Read article
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Nitric Oxide Synthase (NOS) in Breast Carcinoma
Abstract: Breast cancer is the most alarming problem of the current time. Nitric oxide, a free radical gas is synthesized by isoenzymes called nitric oxide synthase. Nitric oxide synthase consists of three isoforms; Nitric oxide produced is cytotoxic which is known to inhibit the DNA synthesis causing its damage. Keeping this in mind, nitric oxide synthase was determined in breast cancer and normal breast tissue. For this tissue from 60 breast …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 23–28 Read article
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Metaplastic Carcinoma Breast Masquerading as Galactocele—A Diagnostic Dilemma: A Rare Case Report
Abstract: Metaplastic breast carcinoma is a rare subtype of invasive carcinomas accounting to about 0.3% of all breast cancers. The World Health Organization (WHO) has classified metaplastic breast carcinoma (MBC) into the pure epithelial type and mixed epithelial and mesenchymal type. The epithelial type MBC subclassified into squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma with spindle cell differentiation; mixed type MBC is subclassified into carcinosarcoma and carcinoma with osseous and chondroid …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 1, 2019 · pp. 14–18 Read article
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Glutathione: Postoperative Study in Breast Carcinoma
Abstract: Breast cancer represents a significant problem in the world. Glutathione a tripeptide is found in all mammalian tissues. Thus any change in its synthesis or utilization can profoundly influence the redox status of cells. In this study blood sample was collected from 60 FNAC confirmed breast cancer patients (preoperative and postoperative three months) and 30 normal healthy controls for the estimation of glutathione. There was significant increase in glutathione in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 3–6 Read article
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Lipid Peroxidation in Postoperative Cases of Breast Carcinoma (Grade III)
Abstract: Breast cancer represents significant problem in the world. Oxidative modification of lipids is catalyzed by reactive oxygen species (ROS) which is known as lipid peroxidation (LPO); this changes the fluidity, permeability of membrane, cellular metabolic functions and causes derangement. Malondialdehyde (MDA) is a major end product and an index of LPO which crosslinks DNA, protein and nucleotides on the same and opposite strands. There are reports that LPO increased in …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 1, 2018 · pp. 16–22 Read article
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A Short Review on Breast Fibroadenomas
Abstract: Breast Fibroadenomas are the most common type of benign breast lumps found mainly in adolescent women. These are unilateral, smooth, demarcated, rubbery, mobile, and painless masses. They are believed to be formed by the influence of changes in the female reproductive hormone, estrogen and sometimes the combination of both estrogen and progesterone which mainly occurs at the time of puberty. Fibroadenomas are mostly found in women till the age of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 8–14 Read article
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Evaluation of Mammographic Breast Density in Benign and Malignant Breast Disease Patients
Abstract: The purpose of the study was to compare the breast density in benign breast disease and carcinoma of the breast and to evaluate the association between breast density and the Breast Imaging Reporting and Data Systems (BIRADS) score to investigate the potential of breast density as a prognostic indicator. In this study, histologically proven cases of 30 benign breast disease patients and 30 breast carcinoma patients were included. Breast density …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 Read article
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Carcinoma Ovary Metastasis to Breast
Abstract: Ovarian cancer commonly metastasises to lymph nodes, lung and liver. Primary ovarian carcinoma metastasising to breast is a very unusual and very few cases are described. Literature reports only 39 cases till date. Most common histological variety of Primary ovarian cancer metastasising to breast is papillary serous adenocarcinoma. Metastasis to breast suggests distant spread of the tumour and hence poor prognosis with median age of survival being 6 months from …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 2, 2016 · pp. 6–10 Read article
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Breast Cancer at Community Level in Bangladesh
Abstract: Background: Breast cancer is an issue of gaining concern in Bangladesh that causes high mortality and morbidity. Lack of screening and surveillance programme contributes to this. Almost no baseline data were found in this issue, though Government of Bangladesh launched a breast cancer surveillance programme based on clinical breast examination (CBE). This research was an effort to produce some baseline data to strengthen the programme of Government of Bangladesh. Methods: …
Published in Research and Reviews : Journal of Surgery · Vol. 8, Issue 2, 2019 · pp. 4–7 Read article
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Efficacy of Tele Rehabilitation in A Stroke Survivor with Aphasia: An Extensive case study
Abstract: Tele-rehabilitation refers to a mode of service delivery where therapy is imparted through tele-mode and tele-rehabilitation is extensively used in the treatment of communication disorders. Many efficacy studies have been reported earlier especially in clients with aphasia; however, most of these studies are western studies and the results cannot be generalised to Indian context, this fact necessitated the present study. The present attempt is a case study; the client was …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 1, 2019 · pp. 10–13 Read article
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Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation
Abstract: There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 45–53 Read article
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Evaluation of Breast Lumps in Women Aged 18–40 Years
Abstract: Background: Finding a breast lump can cause a lot of anxiety. Most breast lumps, particularly in younger women, are not caused by cancer. Aim of study: To identify the out-come of breast lumps in women aged 18–40 year. Patients and methods: A descriptive cross-sectional study conducted at the center of early detection of breast cancer, Elwiya maternity teaching hospital from the first of June 2015 to the end of December …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 1, 2019 · pp. 5–9 Read article
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Breast Cancer Detection and Multiple Classification Using CNN
Abstract: Although some efforts have been made in the form of preventative screening programs, breast cancer remains one of the rising causes of death in women. Computer-assisted diagnosis is needed because of the rapidly increasing number of mammograms that can be collected by these programs. Performance metrics are not significantly improved by computer aided detection methods designed to improve diagnosis without a large number of sequential readings. In this context, self-imaging …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 2, 2023 · pp. 28–38 Read article
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Knowledge and Understanding about Cervical Carcinoma, Risk Factors and Prevention among Rural Women in Pandiruppu, and Maruthamunai Area, Ampara District of Sri Lanka: A Survey
Abstract: Cervical carcinoma has been regarded as the second most common form of cancer among women after breast and colorectal cancer. In Sri Lanka the second most common causes of deaths due to cancer among women is cervical carcinoma. According to the report of Ministry of Health, Sri Lanka in 2007, the estimated number of cervical carcinoma cases was 732. Awareness about cervical carcinoma and its prevention is quite less amongst …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 3, 2015 · pp. 1–4 Read article
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Visualization of genomic sequence in BRCA1 and BRCA2
Abstract: Heredity is the main reason of breast cancer in women and mutation or genetic variations also another reason for the spread of breast cancer. Heredity and genetic variations are responsible 5%-10%, 30%-50% respectively. There are 90% chances of developing neoplasm by the mutations. The effect of BRCA1 and BRCA2 may leads to the variations in DNA therefore it should be in limited amounts so that there will be minimum changes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 49–55 Read article