Search
7 articles for “Benzothiazoles”
-
A Review on Anti-Inflammatory Activity of Benzthiazole Derivatives
Abstract: Benzothiazoles are an important biologically active heterocyclic compounds which contain six membered benzene rings fused with five membered thiazole rings at 1,4 positions. They possess various biological activities like Anti-microbial, Anti-fungal, Anthelmintic, Antioxidant and Anti-inflammatory activities. Benzothiazoles nucleus is believed to produce it’s Anti-inflammatory activity either by inhibiting Beta-2 receptors of Bradykinin or by inhibiting cox₂ enzymes (cyclooxygenase). The present review focuses on some methods of benzothiazoles synthesis and its …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 1, 2022 · pp. 1–13 Read article
-
Synthesis and Characterization of Pyrazole Heterocyclic Derivatives via Vilsmeier-Haack-Reaction and its Schiff`s Bases.
Abstract: The synthesis of New Schiff bases (2; and 3a-c) is reported in this study. These bases were created by reacting -chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (1) with various amines that contained various pharmacophore atoms or groups, such as derivatives of benzothiazole and aniline, in the hopes of having antimicrobial and antifungal properties. Using mild reaction conditions and a good yield percentage, mono-pyrazole Schiff bases (2 and 3a–c) were designed and synthesized by reacting 5-chloro--3-methyl-1-phenyl-pyrazole-4-carbaldehyde …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 34–48 Read article
-
Domino Reaction for the Synthesis of Nitroolefin Heterocyclic Compound Via Thiazole Formation Followed by Claisen Rearrangement
Abstract: The Baylis-Hillman adducts derived from nitroolefins have been conveniently transformed into Claisen rearrangement. These substances, which include benzothiazole moiety, are very biologically reactive substances. This novel nitro derivative of 2-((E)-2-nitro-3-phenylallyloxy)-3-ethoxybenzaldehyde was simply treated with mole percentage of 2-(2-(2-aminophenyl) disulfanyl) benzenamine in melt reactive condition. Hence this novel 2-(benzo[d]thiazol-2-yl)-6-ethoxy-4-((E)-2-nitro-3-phenylallyl)phenol core unit compounds was very intrusting and new opportunities for the preparation of closely related to the different [3,3] sigmatropic rearrangements related …
Published in Journal of Modern Chemistry & Chemical Technology · pp. 18–22 Read article
-
Synthesis, Antibacterial Evaluation and Antifungal Study of New Biochemical Derivatives
Abstract: Bacterial and fungal infections have become widespread recently due to the spread of epidemics, diseases, and bacterial infections. As a result, infection rates have increased, prompting many researchers to develop new antibiotics to reduce the spread of these prevalent diseases. Researchers have prepared biochemical compounds similar in structure to drugs that eliminate infections and reduce their spread. One such derivative is imidazole; a well-known compound used in many medications for …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 19–28 Read article
-
Synthesis, Identification and Bio Evaluation of New Thiophene Derivatives
Abstract: Thiophene is considered one of the most effective cyclic sulfur compounds in organic and pharmaceutical chemistry due to its high stability in various chemical reactions. It plays a key role as an antifungal agent in treating skin allergies, as well as in the preparation of polymers, rubber, and other materials. Recent research has focused on incorporating sulfur compounds into the synthesis of organic compounds because of their high stability in …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 32–44 Read article
-
QSAR Analysis on a Series of Triazole Based Tubulin Polymerization Inhibitors
Abstract: AbstractThe polymerization progression of microtubules is vital to their natural capacities. Polymerization flow allows microtubules to embrace spatial courses of action that can change quickly because of cell needs and, at times, to perform mechanical work. Compounds that interfere with the microtubule-tubulin equilibria in cells are helpful in the treatment of human diseases. A few triazoles mimics of combretastatin-benzothiazole (CAB) hybrids had good activity as inhibitors both of tubulin polymerization …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 2, 2017 · pp. 5–20 Read article
-
LCMS/MS Analysis of the Ethylacetate Extract of Securidaca longipedunculata Fresen (Polygalaceae) Stem Bark
Abstract: The present study aimed to identify some of the phytoconstituents of a fraction (fraction DDK-4) obtained from the column chromatography of the ethylacetate extract of Securidaca longipedunculata Fresen (Polygalaceae). Liquid Chromatography-Mass Spectrometry (LCMS/MS) analysis of fraction DDK-4 was conducted on a Waters Synapt G2 quadrupole time-of-flight mass spectrometer (Milford, MA, USA) using positive mode of ionization. The results showed that 1,7-dihydroxy-2,8-dimethoxy xanthone, 3-(1,3-benzodi-oxol-5-yl-4-morpholinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone, 5,7-dihydroxy-6-methyl-3-(2’,4’-dihydroxybenzyl)-chroman-4-one, trans-O-methyl-grandmarin, dioctylamine, rhodioloside, punicic acid, echimidine, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 1, 2022 · pp. 39–47 Read article