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22 articles for “Anesthesia”
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Frequency of Failed Spinal Anesthesia and Associated Factors in Cesarean Section at Mardan Medical Complex, Mardan, KP, Pakistan
Abstract: Objective: Spinal anesthesia is the preferred choice of anesthesia for parturients having cesarean sections. Despite the high percentage of success in providing acceptable surgical anesthesia, failure of spinal anesthesia has been reported. This study aims to determine the frequency and associated factors related to failed spinal anesthesia during cesarean sections in pregnant women. Methodology: This descriptive cross-sectional study included 149 pregnant women and was conducted at Mardan Medical Complex (MMC) …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 1–9 Read article
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Optimizing Anesthesia for Major Surgery: The Role of Sequential Combined Spinal-Epidural Technique
Abstract: The Combined Spinal Epidural (CSE) approach has been widely employed over the last decade because it achieves rapid onset and substantial blockage while also allowing for the modification or prolongation of the block. Background: Sequential spinal-epidural anesthesia (SSEA) combines the rapid onset and dense blockade of spinal anesthesia with the prolonged duration and adjustable analgesia of epidural anesthesia. This technique is particularly beneficial in major surgeries requiring prolonged operative time …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 · pp. 12–18 Read article
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Comparison of Postoperative Nausea and Vomiting (PONV) Rates in Opioid-Free Anesthesia Protocols Versus Traditional Regimens with Varying Plane Block Techniques
Abstract: Background: Postoperative nausea and vomiting (PONV) continue to be important adverse effects that negatively influence patient recovery and satisfaction following surgery. Opioid-free anesthesia (OFA) and regional plane blocks show potential in decreasing these complications when compared with conventional opioid-based anesthesia (OBA). Objective: To compare the incidence and severity of PONV among patients receiving OFA with transversus abdominis plane (TAP) block versus OBA with TAP or erector spinae plane (ESP) blocks. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 1–6 Read article
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Pharmacogenomics in Anesthesia: Individualized Drug Responses
Abstract: Pharmacogenomics is the study of how a person’s genes influence how they react to medications. Pharmacology, the study of medications, and genomics, the examination of genes and their functions, merge in this field to develop safe, effective drugs that can be prescribed based on an individual’s genetic makeup. Pharmacogenomics examines how an individual’s unique genetic makeup can influence their responses to certain drugs. In anesthesia, where individual responses to pain …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 83–95 Read article
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Needle Choice in Spinal Anesthesia: Is the 25-Gauge Whitacre Superior to the Quincke in Reducing Post-Dural Puncture Headache
Abstract: The process known as endotracheal intubation involves inserting a synthetic tube into the trachea and inflating the former’s cuff to create an airtight seal. Of all the specialized masks in the LMA family, the PLMA is the most intricate. The cuff, the airway tube, the drain (gastric access) tube, and the inflation line with pilot balloon are their four primary components. This drain tube aids in identifying mask malposition and …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 22–30 Read article
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Comprehensive Review on Postoperative Nausea and Vomiting Following General Anesthesia
Abstract: Postoperative nausea and vomiting, often known as PONV, is a common and uncomfortable consequence that occurs after general anesthesia. Patients of all ages are susceptible to experiencing this condition. Even though there have been advances in anaesthesia procedures and treatments, postoperative nausea and vomiting (PONV) continues to be a serious concern since it has the potential to cause patients to experience discomfort, delay their recovery, extend their hospital stays, and …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 2, 2024 · pp. 20–26 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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A Review on Anesthetic Drug Discovery with Computer Aided Drug Design
Abstract: In contemporary medicine, anaesthesia is essential for enabling surgical procedures, pain control, and patient comfort. Finding and creating safe and efficient anaesthetics is crucial to enhancing patient outcomes and developing the medical field. In this review, we provide a comprehensive overview of anesthetic drug discovery with a focus on the integration of computer-aided drug design (CADD) methodologies. Beginning with an exploration of anesthesia mechanisms and targets, we delve into the …
Published in International Journal of Antibiotics Read article
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Comparison of Intravenous Lignocaine and Esmolol in Attenuating Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
Abstract: Objective: This study aimed to evaluate the effectiveness of intravenous lignocaine versus esmolol in minimizing the hemodynamic response during laryngoscopy and intubation. Methods: This prospective, randomized controlled trial included patients scheduled for elective surgery under general anesthesia. Participants were randomly allocated to receive either intravenous lignocaine (Group L) or esmolol (Group E) prior to induction. Hemodynamic parameters—such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 29–44 Read article
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Comparison Of Postoperative Sore Throat Following Endotracheal Intubation With Or Without Water Based Lubricating Jelly
Abstract: Background: Water-soluble lubricant gel (X-Y jelly) was evaluated for its ability to lessen the common throat pain that follows tracheal intubation under general anesthesia. Materials and Methods: scheduled for elective surgery under general anesthesia requiring endotracheal intubation, Were enrolled in a prospective, randomized, double-blind comparative study. They were split evenly into two -member cohorts. One cohort received 3 mL of water-soluble X-Y gel smeared from the cuff tip to 15 …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Prospective Evaluation of the Optimal Concentration and Effect of Epinephrine as an Adjuvant to Local Anesthetics for Prolonging Block Duration and Reducing Systemic Toxicity in Outpatient Surgery
Abstract: Purpose: To evaluate the optimal concentration and effect of epinephrine as an adjuvant to local anesthetics for prolonging block duration and reducing systemic toxicity in outpatient surgery. Methods: The study involved a randomized double-blind clinical trial on 80 adult patients awaiting day-care extremity surgery. The patients were randomly assigned to two groups of equal size. One group, Group E, was given the local anesthetic agent along with epinephrine as an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 64–69 Read article
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Comparison of Recovery Profile for Total Intravenous Anaesthesia (TIVA) Using Propofol And Remifentanil in Laparoscopic Surgeries
Abstract: Total Intravenous Anaesthesia (TIVA) has become an increasingly preferred technique in modern anaesthetic practice due to advantages such as reduced postoperative nausea and vomiting (PONV), improved hemodynamic stability, minimal environmental impact, and faster recovery compared to conventional inhalational anesthesia. Propofol in combination with remifentanil is widely used for TIVA because of its rapid onset and offset of action, which supports quick postoperative awakening and enhanced patient satisfaction. Target Controlled Infusion …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 39–50 Read article
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Microneedles and the paradigm shift in the field of dentistry: A Review Article
Abstract: Needle-based instruments are advancing as a promising tool for both diagnosis and treatment within the medical realm. They possess versatility, being capable of drug delivery and fluid extraction, catering to both systemic and local requirements. Unlike traditional drug delivery methods, which necessitate repeated dosing in the oral cavity due to saliva presence, there's a growing demand for delivery systems like needle-based devices that can offer sustained drug release orally. These …
Published in Research and Reviews: A Journal of Dentistry Read article
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Artificial Intelligence Based Portable Robot Device for Autonomous Venepuncture
Abstract: Venepuncture is a source of medical hurt and is necessary for a wide range of therapeutic procedures. Venpuncture-related complications worsen in difficult settings, where the success rate is largely dependent on the physiology of the patient and the skill of the practitioner. It is difficult to find the vein for infants, adolescent girls, obese and elderly people and it is causing severe pain in the traditional manual blood drawing system. …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 2, Issue 1, 2024 · pp. 35–38 Read article
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Pregnancy-Induced Post-Natal Back Pain
Abstract: Pregnancy-induced post-natal back pain (PNBP) is a common condition that affects many women following childbirth, significantly impacting their quality of life and physical functioning. The physiological and anatomical changes during pregnancy, such as weight gain, altered posture, and hormonal changes, contribute to the onset of back pain. As the body prepares for delivery, the pelvis and spine undergo structural shifts that can strain the muscles and ligaments supporting the lower …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 25–31 Read article
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Extraction of Impacted Lower 3rd Molars immediately after the Single Visit Endodontic treatment of 2nd Molar - A Case Series
Abstract: Patients who visit a dental clinic often anticipate fewer appointments and quicker recovery times. This expectation is particularly relevant when discussing impacted lower third molars in conjunction with decayed second molars. Dentists often struggle with the decision of whether to start endodontic treatment on the second molar or to proceed with extracting the third molar. This dilemma arises due to the absence of sufficient research or documentation specifically addressing the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 2, 2025 · pp. 6–11 Read article
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Electroconvulsive Therapy in the Management of Schizophrenia: A Systematic Review in Emergency Nursing Practice
Abstract: Electroconvulsive therapy (ECT) is a well-established treatment for various psychiatric disorders, including schizophrenia, particularly in cases where patients are resistant to conventional treatments. Schizophrenia, a chronic and severe psychiatric disorder, often presents with a combination of positive symptoms (such as hallucinations and delusions), negative symptoms (such as social withdrawal and emotional blunting), and cognitive impairments. While antipsychotic medications are the primary treatment, approximately 20–30% of individuals with schizophrenia do not …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 43–48 Read article
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Needle Choice in Spinal Anaesthesia: Is the 25-Gauge Whitacre Superior to the Quincke in Reducing Post-Dural Puncture Headache
Abstract: The process known as endotracheal intubation involves inserting a synthetic tube into the trachea and inflating the former's cuff to create an airtight seal. Of all the specialised masks in the LMA family, the PLMA is the most intricate. The cuff, the airway tube, the drain (gastric access) tube, and the inflation line with pilot balloon are its four primary components. This drain tube aids in identifying mask malposition and …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 Read article