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8 articles for “Amyloid Beta”
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Study on Chemical Insights into Alzheimer's Disease: Amyloid Beta and Tau Protein Interactions
Abstract: Background: Alzheimers disease (AD) is the most prevalent form of dementia, affecting millions of individuals worldwide and posing significant challenges to healthcare systems. The disease is characterized by a gradual decline in cognitive functions, particularly memory, reasoning, and the ability to perform daily activities. Aim & objective: To study chemical insights in alzheimers disease, especially amyloid beta and tau protein interactions Results & discussion: The results of this review highlight …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 37–46 Read article
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In silico Prediction of Two New Conformations of Aβ42 Peptide and Possible Mechanism of Their Aggregation
Abstract: Alzheimer’s disease is one of the most studied neurodegenerative diseases. The cause for most cases of this disease is unknown. However, there are many hypotheses regarding the progression of this disease. One of the hypotheses is the amyloid hypothesis. Amyloid precursor protein present on chromosome 21 is cleaved by β and γ sectretases. The cleaved fragments of this protein, nearly 36–43 residues long aggregates and are deposited as plaque in …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 1–7 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Cognitive Impairment in Alzheimer’s Disease
Abstract: Alzheimer's disease (AD) is a condition that leads to the deterioration of brain cells and is the primary cause of dementia, characterized by a decline in autonomy and cognitive function in day-to-day activities. The cholinergic hypothesis and the amyloid hypothesis are the two main theories proposed to explain AD's multifaceted nature. Characterized by a decline in autonomy and cognitive function in day-to-day activities. The cholinergic hypothesis and the amyloid hypothesis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article
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Green Synthesis of Copper Nanoparticle for the Treatment of Neurodegenerative Disease
Abstract: The study of ecologically friendly CuNP synthesis is a growing area with potential applications in biomedical research and environmental remediation, as well as sustainable nanotechnology. Generally, reducing, and stabilizing agents such as microbes, plant extracts, or other natural sources are used. The green synthesis methodology guarantees the production of nanoparticles with desired characteristics for biomedical applications while simultaneously mitigating the environmental effect that comes with conventional chemical processes. CuNPs possess …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 13–24 Read article
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Detection and Classification of Alzheimer’s Disease Using Deep Learning Technique
Abstract: It is crucial that people with Alzheimer's disease (AD) receive a proper diagnosis to begin preventative action before irreparable brain damage develops. Most people who suffer from Alzheimer's disease (AD), a neurological condition that progresses, are older than 65. The area of interest (ROI) in the hippocampus has been extensively studied for several purposes, including neurological illness research, stress development monitoring, and memory function analysis. Moreover, a connection between Alzheimer's …
Published in Recent Trends in Sensor Research & Technology · Vol. 12, Issue 1, 2025 · pp. 15–20 Read article
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Protein Misfolding and Aggregation : A Chemical Perspective
Abstract: Research on protein misfolding has identified several important diseases in which abnormal protein structures play a major role. In Alzheimer’s disease, Amyloid-beta (Aβ) peptides and Tau proteins can misfold and accumulate. Prion diseases are unusual because a misfolded protein can act as a template and encourage other normal proteins to adopt an abnormal structure. Understanding the chemistry behind protein folding is therefore important not only for basic research but also …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 2, 2026 Read article