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39 articles for “Airway”
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Flavonoids Regulate Airway MUC5AC Mucin Expression through Modulation of Multiple Signalling Pathways
Abstract: Airway mucus is a component of pulmonary innate immune function and plays very important role in defense against invading pathogenic microbes, chemicals and particles. The protective function of airway mucus is attributed to the viscoelasticity of mucins. Mucins are large glycoproteins play important role in cell–cell adhesion, airways protection, Nuclear-factor kappa B signalling, epidermal growth factor receptor signalling. Eleven mucin genes (among twenty identified mucin genes) have been expressed at …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 3, 2017 · pp. 21–33 Read article
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Flavonoids Attenuate Airway Mucin Expression, Production and Secretion Induced by Various Inducers
Abstract: Muco-obstructive respiratory disease is caused by changing normal biophysical properties of mucus including alteration of mucin concentration, ion composition and airway surface hydration. Flavonoids are one type of polyphenols which regulate mucin gene expression and consequently inhibit mucus secretion. Thus, this review aimed to discuss the effects of different flavonoids on regulation of various airways mucin gene expression and inhibition of the production of a major airway mucin core protein …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 2, 2019 · pp. 1–13 Read article
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Effects of Gypsophila on Airway Inflammation in Guinea pig model of ovalbumin‐induced Asthma
Abstract: To look at how Gypsophlia (GSP) affects airway inflammation in a model of ovalbumin-induced asthma in guinea pigs (OVA).Methods: Using a random number table, sixty healthy female guinea pigs were split into six groups, each consisting of ten rats: the normal control, OVA, and GSP (0.45, 0.9, 1.8, and 3.6 g/kg). The ovalbumin and lipopolysaccharide sensitization approach was used to create the OVA guinea pig model. The GSP groups received …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 17–23 Read article
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Effect of Nebulization With 3% Hypertonic Saline for Airway Clearance on Mechanically Ventilated Patients Admitted in ICUs of Pt. B.D. Sharma, PGIMS, Rohtak
Abstract: Background of the Study: The ability to breathe artificially prolongs life in many situations. Patients requiring mechanical breathing in the intensive care unit are more likely to have complications and even death due to a variety of interconnected causes. As a result, it became critical to rapidly ventilate in the safest and most efficient manner available. Intubated patients have benefited from nebulized suctioning, as it improves lung clearance and decreases …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 20–27 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Needle Choice in Spinal Anaesthesia: Is the 25-Gauge Whitacre Superior to the Quincke in Reducing Post-Dural Puncture Headache
Abstract: The process known as endotracheal intubation involves inserting a synthetic tube into the trachea and inflating the former's cuff to create an airtight seal. Of all the specialised masks in the LMA family, the PLMA is the most intricate. The cuff, the airway tube, the drain (gastric access) tube, and the inflation line with pilot balloon are its four primary components. This drain tube aids in identifying mask malposition and …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 Read article
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Needle Choice in Spinal Anesthesia: Is the 25-Gauge Whitacre Superior to the Quincke in Reducing Post-Dural Puncture Headache
Abstract: The process known as endotracheal intubation involves inserting a synthetic tube into the trachea and inflating the former’s cuff to create an airtight seal. Of all the specialized masks in the LMA family, the PLMA is the most intricate. The cuff, the airway tube, the drain (gastric access) tube, and the inflation line with pilot balloon are their four primary components. This drain tube aids in identifying mask malposition and …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 22–30 Read article
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Comparative Study of Rocuronium Bromide and Succinylcholine Regarding Ease of Intubating Conditions and Hemodynamic Parameters for Rapid Sequence Intubation in Adults
Abstract: Background: Rapid Sequence Intubation (RSI) is an airway management procedure designed to quickly secure the airway while reducing the likelihood of gastric aspiration during anesthesia induction. For many years, Succinylcholine has been regarded as the preferred neuromuscular blocking agent for RSI because it produces muscle relaxation rapidly and has a relatively brief duration of action. However, its adverse effect profile – including hyperkalemia, bradyarrhythmias, malignant hyperthermia, and increased intracranial and …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 2, 2026 · pp. 33–39 Read article
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The Evolution of Asthma Management: A Comprehensive Analysis of GINA 2024 Guidelines, Endotype-Driven Diagnosis, and Targeted Biologic Intervention
Abstract: Asthma remains a substantial global public health challenge, characterized by heterogeneous airway inflammation leading to variable airflow obstruction. Recent advances in personalized medicine and guideline revisions, notably the Global Initiative for Asthma (GINA) 2024 update, mandate a profound paradigm shift from reliance on short-acting beta2-agonists (SABA) to antiinflammatory reliever (AIR) strategies utilizing inhaled corticosteroid (ICS)-formoterol. This report provides an exhaustive analysis of current asthma epidemiology, molecular pathogenesis distinguishing between Type …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 Read article
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Critical Analysis of Pathyapathya Ahara in Tamaka Shwasa (Bronchial Asthma) in Children
Abstract: Introduction: Asthma is described as a hyper-reactive disorder of airways characterized by airway inflammation and bronchial secretions due to hyper-responsiveness of airway cells. The prevalence of asthma has shown consistently an upward trend through the last few decades, especially in children, and accounts for more school absences and more hospitalizations than any other chronic illness. Materials and Methods: Review from diverse Ayurvedic literatures, pediatric books, research journals, magazines and authentic …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 6, Issue 3, 2019 · pp. 22–30 Read article
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Asthma in Children
Abstract: Asthma is described as a disruptive disease of the pulmonary airways attributable to contraction of airway muscle, accelerated mucus secretion, and infection. The airlines of asthmatic individuals are hyper attentive to a variety of stimuli which includes bloodless air, atmospheric irritants. Pharmacologically lively chemicals, numerous drugs, and hyperventilation. Prevalence in numerous populations of kids ranged from I .37% to II .4% or higher. Most studies record a preponderance of allergies …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 2, 2022 · pp. 20–27 Read article
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Recent Studies of Drugs in Asthma
Abstract: Asthma is a complex illness with a wide range of severity and symptoms. The most prevalent chronic illness impacting children is noncommunicable disease (NCD), which also affects adults. The tiny airways in the lungs become inflamed and constrict, triggering the asthma symptoms, such as coughing, wheezing, shortness of breath, and tightness in the chest. Bronchodilators cause the smooth muscles that surround the airway to relax. The airways enlarge and can …
Published in Trends in Drug Delivery · Vol. 10, Issue 1, 2023 · pp. 16–27 Read article
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Automatic Detection of Misplaced Tubes and Catheters Using EfficientNet B7
Abstract: Tube misplacement can lead to complications in patients together with serious medical malpractice cases. Intubation and the insertion of various medical tubes are employed to safeguard the airways of critically ill patients. Critically unwell patients undergo intubation, with the insertion of various medical tubes to safeguard their airways. The nasogastric tube serves the purpose of providing nutrition, while the central venous catheter finds application in a range of medical procedures. …
Published in International Journal of Computer Science Languages · Vol. 1, Issue 2, 2023 · pp. 9–17 Read article
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Panfacial Trauma- A Case Report
Abstract: The majority of panfacial fractures are accompanied by concurrent organ damage. Panfacial fracture management is difficult and necessitates careful planning, sequencing, and sufficient understanding of the anatomy and management of the condition. In any trauma situation, the ABCDEs (airway, breathing, circulation, disability, and exposure) always remain the primary care priorities. Maxillofacial surgeons are essential in the early stabilization of fractures, the management of localized bleeding into the face, and the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 2, 2024 · pp. 21–25 Read article
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Effectiveness of Twill Technique Vs Endotracheal Tube Holder on ETT Securement: A Comparative Study
Abstract: Endotracheal intubation is an urgent procedure which is performed on patients who are unconscious and can’t breathe by their own. Endotracheal Intubation keeps an airway open and helps to prevent chocking. When the patient is intubated, maintaining the endotracheal tube placement is essential. In case Endotracheal Tube is not secured, even basic nursing management can cause tubing slippage which is a major factor in causing airway trauma or injuries Aim: …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 39–47 Read article
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Chronic Obstructive Pulmonary Disease (COPD) in Younger Adults: Challenges and Considerations – A Review
Abstract: Chronic Obstructive Pulmonary Disease (COPD) phenomenon rapidly converting into chronic significant health issues for many young adults. A disease calculated for older age gives way to early-onset COPD, which creates new issues for diagnosing and treating the illness and even interacts with the quality of life. The article reviews the epidemiology, risk factors, pathophysiology, clinical presentation, and treatment considerations related to this set of conditions. From those risk factors, early-onset …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 08–19 Read article
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Effects of Smoking on Respiratory System
Abstract: Smoking is whispered to exacerbate respiratory diseases by harming respiratory defense mechanisms. Specifically, smoking damages mucociliary function, which impairs clearance of inhaled substances even in smokers who have no respiratory symptoms promotes bacterial adherence to airway epithelial cells. The devastating health impact of cigarette smoking is well known, Cigarette and its components produce structural changes in the respiratory tract include peri-bronchiolar inflammation and fibrosis, augmented mucosal permeability, destruction of the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 5–8 Read article
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A Review on Study of Effect of Guaifenesin
Abstract: Guaifenesin is a very commonly used and prescribed oral expectorant drug. However, its mechanism of action is not completely elucidated and the available information is limited. The purpose was to evaluate whether guaifenesin action on respiratory tract secretion is mediated through a reflex stimulation of the gastric mucosa or by the systemic exposure due to the absorption of the drug to the blood circulation. It was demonstrated that expectorant action …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 3, 2020 · pp. 8–11 Read article
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Development Aspects, Physiochemical Characteristics, Pharmaceutical Requirements and Different Manufacturing Procedures for Dry Powder Inhalation Formulations
Abstract: Dry Powder Inhalation (DPI) products are combination of pharmacologic activity and pharmaceutical properties including procedure used to manufacture. Desirable performance features of DPI are physical and chemical stability, ease of handling, accurate and reproducible delivery to the target organ and availability of drug at the site of action. The physical stability of DPI is of utmost importance as it results in ultimate deposition of drug through various dispersion mechanisms into …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 40–48 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article