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14 articles for “AI in gene delivery”
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Nanotechnology meet phytomedicine towards smarter drug delivery system.
Abstract: Using bioactive substances derived from plants, or phytomedicine, has long shown promise in treating a variety of illnesses with fewer adverse effects than synthetic medications. Nevertheless, a lot of phytochemicals have issues with inadequate targeting in vivo, low bioavailability, poor solubility, and chemical instability. By enabling encapsulation, controlled release, targeted delivery, and stimuli responsive behavior, nanotechnology provides effective tools to get around these restrictions. This review examines the intersection of …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 46–53 Read article
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Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology
Abstract: Biological membranes are important structures that control cellular work, signal transmission, transport, and communication. Dysfunction of membranes has been considered in the development of many diseases, such as cancer, neurodegenerative diseases, and infections, with the distortion of lipid composition, protein activity, and cellular connections involved in the pathogenesis of the disease. The damage on membrane can be caused by oxidative stress, genetic mutation, and environmental influence to disrupt cellular homeostasis. …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 38–46 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Next-Generation mRNA Vaccines: Applications Beyond COVID-19
Abstract: Messenger RNA (mRNA) vaccine technology has become a paradigm shift in contemporary medicine and, with remarkable success in the COVID-19 pandemic, has opened the door to a new wave of vaccines development. In contrast to the traditional vaccine methods, mRNA vaccines are based on the synthetic genetic code that allows host cells to express target antigens, thus eliciting strong humoral and cellular immunity. The speed of development, efficacy, scalability of …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 · pp. 15–26 Read article
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Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health
Abstract: Membrane technology has emerged as a cornerstone in the advancement of artificial organ systems, offering critical functionalities in selective molecular filtration, tissue scaffolding, and controlled therapeutic delivery. Recent innovations have propelled the field beyond traditional polymeric membranes to include nanostructured, biomimetic, and stimuli-responsive materials, significantly enhancing biocompatibility, selectivity, and durability. The integration of smart technologies, such as AI-driven membrane design, bioelectronic sensors, and personalized fabrication via 3D printing, is ushering …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 29–39 Read article
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A review on Design of Gene Therapy and Its Potential for Craniofacial Regeneration
Abstract: One of the most talked-about topics of the 21st century is gene therapy, which holds the promise of treating many diseases. Current gene therapy research explores a wide range of potential treatments, such as enhancing the body’s immune response to tumors, promoting the formation of new blood vessels in the heart to mitigate heart attacks, and preventing HIV replication in AIDS patients. Gene therapy involves the introduction, alteration, or replacement …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 6–12 Read article
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Next-Generation mRNA Therapeutics: Self-Amplifying, Thermostable and Personalized mRNA Vaccines in the Era of Precision Medicine
Abstract: Messenger RNA (mRNA) technology has brought a major change in modern medicine, especially after its successful use in COVID-19 vaccines. However, early mRNA vaccines faced several problems such as low stability, strict cold storage requirements, and lack of personalized treatment. To overcome these challenges, next-generation mRNA technologies have been developed, including self-amplifying mRNA (saRNA), thermostable mRNA vaccines, and personalized mRNA vaccines. This article discusses the development of mRNA therapeutics, the …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 38–54 Read article
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A Conceptual Framework for AI-Integrated Metabolomics in Predictive Health Systems for Resource-Constrained Environments
Abstract: The increasing prevalence of non-communicable diseases (NCDs) continues to place a significant strain on healthcare systems, particularly in low- and middle-income regions where access to early diagnostic infrastructure is limited. Conventional healthcare approaches remain largely reactive, often detecting diseases at advanced stages when treatment effectiveness is reduced. This challenge underscores the need for predictive, cost-effective, and data-driven healthcare solutions. This study presents a conceptual framework that integrates metabolomics with artificial …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 2, 2026 Read article
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Optimizing Nutrient Utilization and Microbial Protein Synthesis in Ruminants: Strategies for Enhanced Feed Efficiency and Sustainable Productivity
Abstract: This review investigates strategies to optimize nutrient utilization and microbial protein synthesis in ruminants, aiming to improve feed efficiency and enhance overall livestock productivity sustainably. It focuses on key aspects of feed formulation, including balancing non-structural carbohydrates with protein sources, incorporating bypass proteins, and selecting high-quality forages that improve fiber digestibility. The review examines various feed processing techniques such as steam-flaking, pelleting, and ammonia treatment, which enhance nutrient bioavailability and …
Published in International Journal of Nutritions · Vol. 3, Issue 1, 2026 Read article
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Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
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Next-Generation Membrane Materials: Advances, Applications, and Challenges
Abstract: Advanced membrane materials are better than regular polymers because they are more selective, permeable, and stable. New developments in nanomaterials, composite membranes, and surface engineering are making it possible to do more with water purification, gas separation, biomedical applications, and energy systems. Membrane technologies have become important tools in many areas, including biomedicine, energy systems, gas separation, and water purification. Recent progress in material science has made it possible to …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 19–28 Read article