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701 articles for “3-(4”
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Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Use of NMR and Other Spectroscopy Techniques in Heterocyclic Oxadiazole Derivatives Studies: A Review
Abstract: It was possible to create a number of novel symmetrical 2,5-dialkyl-1,3,4-oxadiazoles with substituents including carboxymethylamino, isopropyloxycarbonylmethylamino, and bromine at the terminal positions of the alkyl groups. The multistep process that was devised used hydrazine hydrate, phosphorus oxychloride, and commercially available acid chlorides that varied in alkyl chain length and terminal substituent.Diisopropyliminodiacetate was an easy way to substitute the intermediate bromine-containing 2,5-dialkyl-1,3,4-oxadiazoles. This was followed by hydrolysis in an aqueous methanol …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 07–13 Read article
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Synthesis, spectroscopic, crystal structure, Hirshfeld surface, computational, and biological investigations on Isophorone derivatives: 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one
Abstract: FT-IR, 1H NMR, and 13C NMR spectroscopy were among the spectroscopic methods used to synthesize and analyze 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one, a new isophorone derivative. Single-crystal X-ray diffraction (SCXRD) was used to determine the crystal structure, which showed that the molecule crystallizes in a monoclinic system (space group P121/c1) with packing configurations and intermolecular interactions. To learn more about the non-covalent interactions influencing the crystal packing, Hirshfeld surface analysis was used. In order …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–69 Read article
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Investigations On Use of Poly(3,4-Ethylenedioxythiophene): Poly (Styrene Sulfonic Acid) (PEDOT: PSS) Conductive Polymers for Design of Improved EEG Based Brain Computer Interface for Seizure Control and Analysis
Abstract: This research explores the application of Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) conductive polymers in the design of an enhanced Electroencephalography (EEG)-based Brain-Computer Interface (BCI) for seizure control and analysis. PEDOT: PSS, known for its high conductivity, flexibility, and biocompatibility, is employed to improve the efficiency and sensitivity of EEG electrodes, addressing challenges such as signal noise, skin-electrode impedance, and user comfort. The study evaluates the material’s properties, including its electrical conductivity, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 223–241 Read article
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5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one: Synthesis and Reactions
Abstract: The presence of the five-member pyrazole nucleus in different structures leads to a large diversity in its applications. In almost every research study, the pyrazole derivatives biological importance faces a competitive challenge in areas of technology, medicine and agriculture. This reflects the description of these derivatives as antibacterial, antifungal, anticancer, antidepressant, anti-inflammatory, anti-tuberculosis, antioxidant as well as antiviral agents. In our review, we will discuss and show the highlights of …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 Read article
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Investigation of Residual Stress, and corrosion behavior of AA6082/Al 2 O 3 /C/ Si 3 N 4 Composite Material
Abstract: The main objective of the current study was to create AA6082/ Al2O3/C/Si3N4 Composite Material by the use of stir casting. The properties of the AA6082/ Al2O3/C/ Si3N4 Composite Material shown a significant improvement, with a micro-hardness rise of 13.5% and a residual stress decrease of 60%. As the testing parameters were increased, the residual stress of the AA6082/ Al2O3/C/ Si3N4 Composite Material rapidly decreased from -65MPa to -15MPa. An electromagnetic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1104–1109 Read article
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Synthesis of Magnetically Recoverable Nickel (II) Complex-Functionalized Fe 3 O 4 @ISNA (ISNA= Isonicotinic acid) Nanomaterials: Catalytic Studies on Nitrophenol Reduction and TD- DFT Studies
Abstract: In this study, we aimed to develop a novel, environmentally sustainable, and magnetically separable heterogeneous nanocatalyst, denoted as Fe 3 O 4 @ISNA@NiL (where L represents the ligand). The synthesis involved a two-step process, first, isonicotinic acid was chemically grafted onto the surface of iron oxide nanoparticles (Fe 3 O 4 ) to introduce functional groups capable of further chemical modification. Subsequently, a nickel(II) Schiff base monomeric complex was anchored …
Published in Journal of Polymer & Composites Read article
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Chompound contaning oxadiazole derivatives and their potential therapeutic uses.
Abstract: Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring's aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 68–74 Read article
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Optimization of Seed Viability Tests for Humulus lupulus
Abstract: The Humulus lupulus member of the Hemp family has been extensively explored for their industrial application in diverse sectors. During the cultivation of this high-cost plant, one of the major concerns associated is low seed germination due to physical dormancy. The role of rigid seed coats in augmenting an impermeable barrier for water and nutrient availability to the seed has been well analyzed in previous studies. However, the associated impact …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Tb3+ activated Boro Phosphate Glass: Synthesis and Photoluminescence (PL) Characteristics
Abstract: The (40B2O3+ 3Al2O3+(10-x) P2O5 + xTb + 7ZnO+5LiCO3+ 10H6NO4P+25SrCO3) boro phosphate glass was successfully synthesized via melt quenching method. The structural confirmation is supported with X-ray diffraction (XRD) data and surface morphology was defined by scanning electron microscope (SEM). The (40B2O3+ 3Al2O3+(10-x) P2O5 + xTb+ 7ZnO+5LiCO3+ 10H6NO4P+25SrCO3) boro phosphate glass has been investigated for its Photoluminescence (PL) under UV excitation. At 544 nm, the excitation was observed, and at 222 …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 43–47 Read article
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Determining the Effect of Applying Different type and Rate of NPSB Fertilizers on Yield of Common Bean at Wolaita Zone Boloso Sore Woreda, South Ethiopia
Abstract: The research was conducted to determine effect of different types and rate of NPSB and CU fertilizers on yield of common bean at boloso sore woreda at rain-feid condition for two years (2016 & 2017) at Areka research center, located at an altitude of 1830 masl, latitude 07° 4’ 24’’ N, longitude 37° 41’ 30’’ E, temperature: 20.3° C, rainfall: 1200-1700 mm, soil type: Haplic alisol. A completely randomized block …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 2, 2024 · pp. 1–6 Read article
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Current Developments In 4D Printing Technology
Abstract: The perception of four-dimensional (4D) printing expertise was prompted through the time dimension inclusion in three-dimensional (3D) printing. Many other industries, including engineering, health, and the arts, have revealed a great deal of attention it. Recently, innovations in bioscience have been established that can be implemented using 4D printing. The ability to integrate time with situational variations has many benefits, but perceptibility and adaptability are merely two. Smart material, stimulus, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 108–120 Read article
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Evaluation of the Formation, Concentration, and Mitigation of Heterocyclic Amines in Selected Nigerian Proteinaceous Delicacies
Abstract: This study characterised the kinetics and concentration profiles of six HCA congeners — 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), 1-Methyl-9H-pyrido[3,4-b]indole (harman), and 9H-pyrido[3,4-b]indole (norharman) — in six Nigerian food preparations (grilling of popular delicacies — including suya, kilishi, asun, and smoked catfish (eja aro)) using validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) under three cooking modalities (charcoal grilling, pan-frying, oven-roasting). The inhibitory potential of five natural marinade formulations — …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Effect of Particle Size Mix Ratio of Clay and Agro-Based Material for AGO and PMS Treatment on Microbial Growth
Abstract: The characteristics of possible microbes isolated and identified on adsorption process involving AGO and PMS as contaminants in fresh water medium was monitored using agro – based materials. The formulated adsorbent is made of clay with ago-based materials of Banana Ogoni Red (BOR) Banana Native (BN), Plantain Agbagba 1 (PA1), and Plantain Ogoni Red (POR). The particle size mixed ratio of clay to the various agro-based materials were 150𝜇𝑚 R5:5, …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 2, 2024 · pp. 05–14 Read article
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Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds
Abstract: Polymer chemistry plays a fundamental role in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that replicate the intrinsic characteristics of native tissues. The regeneration of damaged tissues, especially within anatomically complex structures such as bone, cartilage, and skin, necessitates biomaterials that closely emulate the hierarchical architecture and biological functions of native extracellular matrices (ECMs). The capacity to replicate both mechanical and biochemical cues of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 7–13 Read article
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An in-silico toxicity study of the phytocompounds found in Pongamia pinnata leaves using the ProTox-II web server
Abstract: The aim of the current study was to determine the Insilco toxicity of the phytocompound present in the leaves of Pongamia pinnata. The leaves of Pongamia pinnata have long been used in traditional medicine for their therapeutic properties. Nowadays, herbal toxicity is a common problem caused by incorrect dosage. The FDA reviews the safety and effectiveness of herbal products only in response to patient or health care provider complaints—problems with …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 Read article