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706 articles for “sil”
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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An overview of Nanocrystalline Hydrogenated Silicon Thin film Transistor
Abstract: This article elaborates and comprehends an overview on nc-Si:H TFT's, detailing and highlighting the topics like fabrication methodology, properties/stability, modelling, characterization techniques, challenges and futuristic scope/applications.With the growing demands in commercialization of Solar Cells (low-cost photo voltaic devices), Large Area Displays (like OLED’s), Thin film electronics (FPD applications), pixel switches, wearable/flexible electronics and so on, has prompted researchers to develop nc-Si:H TFT's (an alternative solution) which can out perform the …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 2, 2025 · pp. 1–23 Read article
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Silent Submarine Propulsion with High-Efficiency Magnetohydrodynamic Drive
Abstract: Magnetohydrodynamic (MHD) propulsion is an exciting technology that can be easily incorporated into a new submarine or existing one can also be upgraded by replacing the propeller drive with a MHD drive without difficulty. This new technology would provide many advantages like a stealth operation, no cavitation, greater maneuverability, increased payload, addition of an emergency drive system, etc. The design of an MHD motor is very simple and consists of …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 1, 2025 · pp. 41–55 Read article
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Unveiling the Silent Threat: The Escalation and Defence Against Antibiotic Resistance
Abstract: The global challenge of antibiotic resistance presents a significant risk to public health, driven by multifaceted factors worldwide. This issue, akin to the impacts of climate change, requires concerted efforts at national and international levels to mitigate its consequences. Antibiotics have revolutionized modern medicine, enabling critical interventions like surgeries, transplants, and cancer treatments. However, without global collaboration, we face significant setbacks across medical, social, and economic domains. Initiatives to address …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–26 Read article
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Investigation, Fabrication and Testing of Spur Gear Using Composite Material
Abstract: Composite materials constitute one of the favorable, efficacious material zones for tomorrow’s sustainable future through identification of materials with higher strength to weight ratio. A composite material is combination of two or more different materials with varied qualities that work together to create a material that is better than the sum of its parts. Therefore, finding some alternative material for various mechanical applications to accelerate the Indian composite industry is …
Published in Journal of Experimental & Applied Mechanics · Vol. 16, Issue 2, 2025 · pp. 1–8 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Sustainable High-Strength Geopolymer Composite Reinforced with Nano-Silica and Basalt Fibers: Mechanical and Microstructural Evaluation
Abstract: Sustainable soil composites (SSC) were formulated by incorporating red earth with varying proportions of bagasse ash (BA) and hydrated lime to enhance geotechnical performance and promote the reuse of agro-industrial waste. Red earth served as the primary structural matrix, BA functioned as a pozzolanic filler, and lime acted as a chemical stabilizer. BA content ranged from 0% to 60%, identifying 10% as the optimum level for significant improvement, and lime …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 1113–1122 Read article
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Performance Evaluation of Concrete with Binary and Ternary Blends of Fly Ash, Silica Fume, and Fiber Reinforcement
Abstract: This study evaluates the effect of ground granulated blast furnace slag (GGBS) as a partial replacement for cement on the mechanical properties of concrete, focusing on compressive and split tensile strength. Concrete mixes were prepared with GGBS replacement levels of 0%, 25%, and 50% and subjected to different curing methods, including water curing, steam curing, and conceal curing. These curing methods were selected to investigate their impact on hydration, strength …
Published in Journal of Construction Engineering, Technology & Management · Vol. 15, Issue 3, 2025 · pp. 40–45 Read article
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Interaction of Mosquito’s hppd Enzyme with Lansoprazole Sulfide A New Hope to Tackle the Mosquito Menace – an in-Silico Study
Abstract: Tyrosine detoxification is an important physiological process that helps blood-feeding insects, such as mosquitoes that transmit Plasmodium parasites causing malaria, digest their blood meals. An enzyme known as 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is part of the tyrosine detoxification pathway, helps in removing excess tyrosine in a high-protein blood meal. Excess tyrosine can be lethal to the insects, and hence, the role of HPPD enzyme is very critical. Inhibitors of HPPD …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Enhancing Mechanical Performance in Reinforced Hybrid Composites using Silicon Carbide and Aluminium Oxide Fillers
Abstract: Hybrid composites are becoming useful because they have better qualities than regular composites. This study examines the conventional properties of composites that utilise SiC and Al2O3 as filler components. Kevlar, S-glass, and sisal fibers at 90° and 0°, followed by additional layers of S-glass and Kevlar. To make sure that the material qualities were the same throughout, the resin and fibre layers were arranged in an alternating pattern. Mechanical testing …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 934–945 Read article
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INVESTIGATION OF THERMAL CONDUCTIVITY OF SILVER NANOPARTICLES IN BASEFULID OF WATER ETHYLENE GLYCOL
Abstract: Nanotechnology is interface technologies that span many different science and applications area.When engineering, science and technology are conducted at the nanoscale is called asnanotechnology. It is about 1 to 100 nm (nano-meter) where nano denotes the scale range of onebillionth of meter. Nanotechnology refers the properties of atoms and molecules measuring 0.1 to1000 nm. Nanofluids are nothing but suspension of nanometer sized particles in the base of fluid.The base fluid …
Published in Journal of Thermal Engineering and Applications · Vol. 7, Issue 3, 2020 · pp. 13–19 Read article
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Synthesis and characterization of mesoporous silica supported Pt catalysts for Decalin dehydrogenation
Abstract: Hydrogen, potentially very attractive energy source as its combustion forms only water in addition to energy. Hydrogen is the cleanest source of fuel. Decalin consists of considerable high hydrogen contents of 7.3 wt% and 64.8 kg H2 /m3 is an excellent mobile storage source for hydrogen. In this work, SBA-15 and carbon modified SBA-15 supported 1wt% Pt catalysts were synthesized and characterized for vapour phase dehydrogenation of decalin. About 154 …
Published in Journal of Catalyst & Catalysis · Vol. 5, Issue 3, 2018 · pp. 12–21 Read article
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The Role of Surface Treatments on Mechanical and Interfacial Shear Strength of Pineapple Leaf Fibers
Abstract: Natural fibers are seen as having potential application as reinforcing agents in polymer composite materials due to their main advantages, which include moderate strength and stiffness, low cost, and being an environmentally beneficial, degradable, and renewable material. They are susceptible to absorbing moisture because of their innate hydrophilicity, which can weaken or plasticize the adherence of the fibers to the surrounding matrix and impact the performance of composite materials employed …
Published in Journal of Materials & Metallurgical Engineering · Vol. 12, Issue 3, 2022 · pp. 18–28 Read article