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307 articles for “gene regulation”
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Leveraging Full Stack Data Science for Healthcare Transformation: An Exploration of the Microsoft Intelligent Data Platform
Abstract: The rapid progress of the Fourth Industrial Revolution has been largely driven by the evolution of artificial intelligence (AI), with notable contributions from technologies such as Generative Pre-trained Transformers (GPT). This revolution has seen the convergence of physical, digital, and biological technologies, leading to transformative impacts across various sectors. Data science, serving as a crucial enabler, has enabled the development of intelligent value chains. However, the application of data science …
Published in Journal of Advanced Database Management & Systems · Vol. 11, Issue 3, 2024 · pp. 1–8 Read article
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The Role of Gut Microbiota in the Health Effects of Fermented Dairy Products
Abstract: The human gut microbiota plays a crucial role in maintaining physiological health, influencing digestion, metabolism, immune function, and even mental well-being. Among dietary interventions aimed at modulating gut microbiota, fermented dairy products have emerged as particularly promising due to their rich content of live microorganisms, bioactive compounds, and nutrients. This review explores the intricate interactions between fermented dairy products and the gut microbiota, highlighting their potential health benefits and underlying …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 5–10 Read article
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Graphene Based Electronic Skin for Wearable Health Monitoring and Human– review on Machine Interaction, Materials, Structures and AI Integration
Abstract: Graphene-based electronic skin (e-skin) has emerged as a transformative technology for next-generation wearable health monitoring and advanced human–machine interaction (HMI). Owing to its outstanding electrical conductivity, mechanical flexibility, atomic-scale thickness, and biocompatibility, graphene enables the fabrication of ultrathin, conformal, and multifunctional sensors capable of mimicking the sensory functions of natural human skin. Over the past decade, research in this domain has progressed rapidly across four interconnected fronts: material synthesis and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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POLYMER NANOCOMPOSITES AT THE NANOSCALE: A COMPREHENSIVE REVIEW WITH REFERENCE TO INDIAN REGULATIONS
Abstract: By combining the nanoscale reinforcements with polymer matrices, polymer nanocomposites have become one of the most promising classes of advanced materials with superior mechanical, thermal, electrical, barrier and multifunctional properties. This extensive review critically analyses the scientific advances made in polymer nanocomposites between 2000 and 2026, with focus on recent advances in polymer nanocomposite development, processing techniques, structure–property relationships and new applications. The review covers the impact of the nanofillers …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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A study on Public Perception and self-medication practices with Over-the-counter (OTC) Drugs
Abstract: Over-the-counter (OTC) medications are commonly used by individuals for self-medication due to their easy availability and the general belief that they are safe. However, misuse can lead to negative health outcomes such as adverse reactions, drug interactions, and delays in seeking professional medical care. In a country like India, where enforcement of drug regulations can vary and socioeconomic factors play a major role, the practice of self-medication is especially widespread. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 01–07 Read article
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CFD Analysis of Six-Flow Microchannel Heat Sink Using the Different Nanofluid
Abstract: In this study, we compare the heat-conveying capabilities of ordinary water with those of cooling fluids such as Ag-Water, TiO2-water, and Al2O3-water nanofluid at a volume percentage of 0.50%, and we also examine the six flow micro-channels of the fin-equipped heat sink. Hardware like microprocessors and integrated circuits are not used in the comparison. To evaluate the effectiveness of different cooling fluids, a number of thermal metrics are used, such …
Published in Journal of Polymer & Composites · Vol. 11, Issue 11, 2023 · pp. 1–11 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Polymer Chemistry of Ion-Selective Membranes and Hydrogels for Clinical Sodium Sensing: Advances and Perspectives
Abstract: Accurate and timely monitoring of serum sodium levels is critical in diagnosing and managing hyponatremia, a common and potentially life-threatening electrolyte disorder. Recent advances in polymer chemistry have driven the development of ion-selective membranes and hydrogels tailored for clinical sodium sensing, bridging the gap between material science and biomedical diagnostics. This review critically examines the design and synthesis of polymeric materials—focusing on block copolymers, conductive polymers, and stimuli-responsive hydrogels—used to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 895–901 Read article
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Enhancement of LVRT Capability in DFIG based Microgrids Using STATCOM
Abstract: The improvement of a grid-connected wind microgrid's Low Voltage Ride-Through (LVRT) capability using a Static Synchronous Compensator (STATCOM) is investigated in this research. The increasing penetration of wind energy into modern power systems necessitates advanced control strategies to maintain grid stability during voltage disturbances and fault conditions. In this study, a STATCOM is employed with an effectively tuned PI controller to provide enhanced dynamic response, voltage regulation, and reactive power …
Published in Trends in Electrical Engineering · Vol. 16, Issue 2, 2025 Read article
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Design and Development of an Electromagnetic Propulsion Train
Abstract: The recent advancement of new transportation techniques led to the search for methods of propulsion that were superior to classical mechanical systems. Among these new moments, electromagnetic propulsion (EMP) has attracted attention because this technique allows for motion generation via electromagnetic force without using conventional wheel-based friction processing. The paper describes the conceptual design, principle of working and performance evaluation of a prototype model train to be propelled electromagnetically.The system, …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 19–24 Read article
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Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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A Study on Precision Blood Propulsion in Motor-Driven Artificial Hearts
Abstract: The development of biocompatible, energy-efficient pumping mechanisms is pivotal for advancing artificial heart (AH) technology. This study explores a motor-driven centrifugal pump designed to replicate the physiological dynamics of natural ventricles while mitigating complications associated with conventional axial and pulsatile systems. The proposed system employs a brushless DC motor with closed-loop control, integrated with pressure and flow sensors to modulate rotational speed (RPM) and generate biomimetic cardiac output. The suggested …
Published in Trends in Electrical Engineering · Vol. 16, Issue 1, 2025 · pp. 53–59 Read article
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A study in Leveraging Deep Learning and IoT Arrays for Dynamic, Hyper-Local Atmospheric Intelligence
Abstract: The critical demand for high-resolution, actionable atmospheric data is challenged by the high cost and sparse coverage of traditional regulatory monitoring stations. This paper explores the synergistic paradigm shift enabled by integrating low-cost, dense Internet of Things (IoT) sensor arrays with advanced Artificial Intelligence (AI) methodologies, specifically Deep Learning (DL) models. We address the primary limitations of low-cost sensors—inherent bias, sensitivity to environmental drift (temperature/humidity), and calibration inconsistency—by utilizing AI …
Published in International Journal of Atmosphere · Vol. 2, Issue 2, 2025 · pp. 50–62 Read article
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The Curious Case of the Sphered Blood Cells: Unveiling Hereditary Spherocytosis
Abstract: Hereditary spherocytosis (HS) is an inherited blood disorder that disrupts the shape and flexibility of red blood cells (RBCs) due to genetic mutations. These abnormal, sphere-shaped RBCs, called spherocytes, are prematurely destroyed in the spleen, leading to hemolytic anemia. Symptoms range from mild fatigue to chronic weakness and shortness of breath. While incurable, Hereditary spherocytosis can be effectively managed. Regular monitoring, folic acid supplementation, and in severe cases, splenectomy (surgical …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 49–57 Read article
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The Integration of Artificial Intelligence in Ophthalmology: Augmenting Clinical Decision or Clinical Dependency?
Abstract: The diagnostic accuracy of artificial intelligence (AI) algorithms for glaucoma and diabetic retinopathy screening is on par with or higher than that of skilled doctors. Their acceptance has accelerated due to regulatory clearances, practical implementation in telehealth networks, and growing proof of cost-effectiveness. However, this very success raises a question that the field has been reluctant to address: are we unintentionally undermining the clinical reasoning abilities of the upcoming generation …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 31–34 Read article
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article
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Energy-Efficient Thermal Management: Advanced Cooling Techniques for Electronics, Automotive, and Aerospace Applications
Abstract: The growing demand for energy-efficient systems across diverse industrial sectors, including electronics, automotive, aerospace, and renewable energy, has elevated the importance of advanced thermal management techniques. Effective heat dissipation is critical not only for maintaining optimal operating conditions in electronic devices but also for enhancing the performance and reliability of broader energy and mechanical systems. Inadequate thermal management can compromise energy efficiency, reduce component lifespan, and increase environmental impact. This …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 18–23 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article