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186 articles for “cancer treatment”
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Gene prioritization of colorectal cancer using computational approach
Abstract: Colorectal cancer (CRC) continues to be a major worldwide health issue, underscoring the need to pinpoint crucial genetic elements influencing its initiation and advancement. In this investigation, we utilize sophisticated computational methods to prioritize potential genes linked to CRC development. Through the utilization of various bioinformatics tools and comprehensive methodologies, we systematically examine extensive microarray datasets to identify potential genetic contributors. Initially, a vast amount of CRC microarray data (approximately …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 39–52 Read article
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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Comprehensive Review on Sterilization Methods and Material Considerations
Abstract: The problem of environmental contamination, which is important for both public health and the economy, has been addressed through a great deal of research on the sterilization and disinfection of pollutants and microorganisms. Many types of pollutants and hazardous materials, such as microorganisms and toxic gases, are discharged into the environment and can enter the human body through ingestion, adsorption, or inhalation. Numerous respiratory conditions, strokes, lung cancer, and heart …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 2, 2025 · pp. 25–32 Read article
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Revolutionizing Energy Systems: The Impact of Steam and Its Technological Evolution
Abstract: The problem of environmental contamination, which is important for both public health and the economy, has been addressed through a great deal of research on the sterilization and disinfection of pollutants and microorganisms. Many types of pollutants and hazardous materials, such as microorganisms and toxic gases, are discharged into the environment and can enter the human body through ingestion, adsorption, or inhalation. Numerous respiratory conditions, strokes, lung cancer, and heart …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 2, 2025 Read article
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Innovations in Gene Therapy: Revolutionizing Treatment for Genetic Disorders and Diseases
Abstract: Gene therapy is a revolutionary intervention in the treatment of genetic diseases since it is an intervention that aims at the very source of diseases, through editing and modification of genes. More recent innovations in gene editing systems, such as CRISPR-Cas9, CRISPR-Cas12, and prime editing, have greatly increased the accuracy and effectiveness of gene therapies, enabling more specific therapies. The opportunities of personalized medicine are also extended by the creation …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Biodegradable Polymer Composite Materials for Long-Term Drug Release in Pharmacotherapy
Abstract: Biodegradable Polymer composite materials are a promising choice for controlled drug delivery because they let medicine be released slowly over time during treatment. These structures, which are made from safe, recyclable plastics, work well to make sure that drugs stay in the body for a long time. This means that patients will take their medicine less often and more consistently. As the body breaks down these structures, the drug inside …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 533–546 Read article
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Multi-Target Molecular Docking of Anantmul (Hemidesmus indicus) Compounds for Tay-Sachs Disease Treatment
Abstract: This research aimed to study the effects of the plant Anantmul (Hemidesmus indicus) in the treatment of Tay-Sachs disease using molecular docking studies. Tay-Sachs disease is a neurodegenerative autosomal recessive disorder caused due to accumulation of the molecule GM2 ganglioside which is caused due to lack of enzyme Beta Hexosaminidase which breaks down GM2 Ganglioside. Anantmul (Hemidesmus indicus) is a an ayurvedic plant used in the Indian subcontinent that has …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 61–69 Read article
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Microneedles and the paradigm shift in the field of dentistry: A Review Article
Abstract: Needle-based instruments are advancing as a promising tool for both diagnosis and treatment within the medical realm. They possess versatility, being capable of drug delivery and fluid extraction, catering to both systemic and local requirements. Unlike traditional drug delivery methods, which necessitate repeated dosing in the oral cavity due to saliva presence, there's a growing demand for delivery systems like needle-based devices that can offer sustained drug release orally. These …
Published in Research and Reviews: A Journal of Dentistry Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women
Abstract: Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of "androgens", which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 21–28 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Classification of Skin Disease Images Using EfficientNetTransfer Learning Technique
Abstract: Melanomous Skin lesions are among the deadliest kinds of cancer. Despite being a very uncommon skin condition, melanoma is responsible for 75% of cancer-related deaths. Dermatologists perform dermoscopy more commonly than any other procedure. Since it aggravates the skin condition, a dermatologist will be the first to identify it during an inspection. Because this strategy depends on the user's visual perception and experience, it can only be used by highly …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 1, 2024 · pp. 7–12 Read article
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Machine Learning-Driven Early Prediction and Prevention of Obesity and Overweight
Abstract: Obesity has become a global health concern, with its prevalence reaching alarming levels in recent years. By classifying obesity-level, healthcare professionals can assess an individual's risk and develop appropriate treatment and prevention strategies. Healthcare professionals can customize interventions and create personalized treatment plans based on individual needs. This paper delivers a system provides an overview of obesity, highlighting the importance of accurate and standardized categorization for effective management and treatment …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 31–40 Read article
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A Review on Manihot Esculenta Species
Abstract: Manihot esculenta, which is commonly known as Cassava, is a woody shrub that provides a high source of carbohydrate. It is an annual crop native to tropical and subtropical regions of the world. Nigeria is the largest producer of the cassava plant. The parts of the plant like leaves, roots, stems, etc are consumed in a variety of ways as they have been shown to possess activities like analgesic, anti-inflammatory …
Published in Research & Reviews : Journal of Botany Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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Graphene-Polymer Nanocomposites for Drug Delivery Applications
Abstract: Graphene-polymer nanocomposites (GPNCs) have gained significant attention in drug delivery due to their exceptional physicochemical properties, including high surface area, mechanical strength, tunable functionality, and biocompatibility. These nanocomposites integrate graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), with biocompatible polymers to enhance drug loading efficiency, stability, and controlled release. Various natural (chitosan, alginate) and synthetic (PLGA, PEG, PCL) polymers are used to functionalize graphene, enabling targeted …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 362–374 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article