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216 articles for “Insulin/IGF1-AKT-mTOR”
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article
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Nutritional Management of Polycystic Ovarian Disease: Integrating Unani and Contemporary Approaches
Abstract: In Unani medicine, dietary management, known as Ilaj bil Ghiza, plays a vital role in restoring humoral balance and maintaining a healthy temperament (mizaj). This principle aligns with modern medical understanding, particularly in conditions, like polycystic ovarian syndrome (PCOS), which is often associated with insulin resistance and obesity. Modifying dietary habits has shown promise in improving both metabolic and reproductive functions in PCOS patients. Unani scholars attribute PCOS to a …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2025 · pp. 1–6 Read article
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Tackling Water Hardness: Understanding the Issue for Sustainable Development
Abstract: Hard water poses a serious threat to human health and industrial operations. The pervasiveness of water hardness, characterized by elevated concentrations of calcium and magnesium ions, originates from seepage and runoff from soils, as well as polyvalent metallic ions from sedimentary rocks. These minerals, while essential in moderate amounts, can become problematic when consumed in excess. Epidemiological studies have established correlations between excessive consumption of calcium and magnesium and increased …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 2, 2025 · pp. 73–79 Read article
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The Role of Gut Microbiota in the Health Effects of Fermented Dairy Products
Abstract: The human gut microbiota plays a crucial role in maintaining physiological health, influencing digestion, metabolism, immune function, and even mental well-being. Among dietary interventions aimed at modulating gut microbiota, fermented dairy products have emerged as particularly promising due to their rich content of live microorganisms, bioactive compounds, and nutrients. This review explores the intricate interactions between fermented dairy products and the gut microbiota, highlighting their potential health benefits and underlying …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 5–10 Read article
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Role of Inflammatory Markers and Lipid Abnormalities in Glycemic Dysregulation Among Type 2 Diabetics
Abstract: Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by systemic inflammation and associated with various complications in multiple organs. Type 2 diabetes mellitus (T2DM) specifically involves insulin resistance, hyperglycemia, and inflammatory responses. This study investigates the levels of various inflammatory markers and their correlation with glycaemic control in T2DM patients.Objective: To evaluate the levels of inflammatory markers (including NLR, PLR, SII, SIRI, CRP, IL-6, TNF-α, TGF-β, MCP-1, IL-4, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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A Systematic Review on Diabetic Encephalopathy, Its Type & Biomarkers
Abstract: Diabetes and its complications become a major reason of morbidity and mortality associated with the changes of life style. Diabetic Encephalopathy is one of the complication of Diabetes Mellitus. The aim of this paper is to review the information on Diabetic Encephalopathy with emphasis on its etiology , pathogenesis and its treatment. Diabetic encephalopathy is the condition in which impairment of brain function occur. Diabetic encephalopathy is the complication of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 98–117 Read article
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Association of Metabolic Syndrome with Cholelithiasis in Female Patients and Its Impact on Clinical Management and Surgical Outcome
Abstract: Background: Metabolic syndrome (MetS) is associated with obesity, insulin resistance, dyslipidemia, and hypertension, which may predispose to gallstone formation. This study aimed to evaluate the association between MetS and cholelithiasis in female patients and to assess its impact on clinical presentation, surgical difficulty, and postoperative outcomes. Methods: A prospective observational study was conducted on 88 female patients with ultrasonography-confirmed cholelithiasis. Patients were divided into two groups: MetS (n=44) and non-MetS …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 · pp. 1–7 Read article
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Comprehensive Study and Triggering Factors of Alcoholic and Non-Alcoholic Fatty Liver
Abstract: Over the past few years, fatty liver disease has turned out to be a rather widespread phenomenon and has become a serious issue with the global population nowadays. It comprises alcoholic fatty liver disease and non-alcoholic fatty liver disease, which develop under the influence of various initiating factors, though frequently follow similar pathologies. The overloading of lipids in the hepatocytes in most cases will be the first sign of the …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 43–52 Read article
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Impact of Spinal Cord Injury on Body Composition and Weight
Abstract: Weight gain is a common consequence of spinal cord injury (SCI), often resulting from decreased physical activity, metabolic alterations, and changes in body composition. This study aimed to assess post-injury weight changes among individuals with SCI. Data was obtained using a multistage random sampling method, utilizing a patient questionnaire administered to 28 individuals diagnosed with SCI. Participants’ baseline weights were compared with their recorded weights at follow-up. The mean initial …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 19–34 Read article
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Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.
Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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Monoclonal Antibodies in Next Generation Animal Nutrition: Mapping Nutrient Immune Interaction Networks in Livestock Systems
Abstract: Sustainable livestock production is increasingly constrained by disease pressure, antimicrobial resistance, and declining feed efficiency under intensifying environmental stressors. Conventional nutritional strategies, while essential, remain insufficient to precisely regulate immune function and metabolic resilience. This review explores the emerging role of Monoclonal antibodies as advanced biologics in next generation animal nutrition, with a focus on mapping nutrient immune interaction networks in livestock systems. It synthesizes current knowledge on how nutrients …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 · pp. 20–32 Read article
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Childhood Obesity: From Determinants to Clinical Management strategies
Abstract: Childhood obesity is one of the major global health problems in whole world, with a dramatic increase in prevalence over the recent few decades. Obesity associated with very serious long term health complications and sometimes very serious complications, such as metabolic disorders, cardiovascular, neurological, renal and psychological disorders. There are various factors such as genetic, environmental, behavioural, and socio-economic factors are some key player in the pathogenesis of obesity. In …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 45–53 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Nutrient Sensing and Microbiota Crosstalk: Driving Determinants Shaping Metabolic Stability and Adaptive Physiology for Animal Health
Abstract: Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Diabetes Risk Prediction from Survey Data Using Machine Learning Algorithms
Abstract: Diabetes mellitus represents one of the most significant global health challenges, affecting millions worldwide and leading to severe complications if left undiagnosed or poorly managed. Early detection and risk assessment are crucial for preventing the progression of this chronic condition. This research presents a comprehensive machine learning approach for predicting diabetes risk using survey-based health parameters. The study implements and compares four prominent classification algorithms: Logistic Regression, K-Nearest Neighbors (KNN), …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 1–8 Read article
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A Study on Promoting Physiological Personalities of the Students by Vethathiri Maharishi’s Nine-Center Meditation Using Quantum Magnetic Resonance Analyzer
Abstract: AbstractThe nine-center meditation of simplified Kundalini yoga was formulated by sage Vethathiri Maharishi. It involves the following centers: Mooladhara, Swadhistana, Manipuraga, Anahatha, Visuddhi, Agna, Thuriya, Shakthi Kalam and Shiva Kalam. Meditation is done on all the nine centers, seven of which are endocrine glands located within the physical body and Shakthi Kalam, Shiva Kalam are universal field and absolute space respectively. Meditation commences at Mooladhara Chakra, followed by meditation on …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 1, 2014 · pp. 62–66 Read article
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Effect of Tareeq (Sweating) in Waja-ul-Mafasil (WM) of Samane Mufrat (Overweight/Obesity)—A Study
Abstract: Samane Mufrat (obesity) occurs due to decrease in hararate ghareezia (innate heat). It is a chronic and increasingly common disease characterized by excess body fat. It is more prevalent in women because of their barid mizaj (cold temperament). The shaham wa sameen (fats) are barid ratab (cold wet), so they accumulate in barid mizaj individuals. As body mass index (BMI) values increase, joint pain symptoms and severity increase. Joint pain …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 9, Issue 3, 2020 · pp. 18–21 Read article
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Effect of Tareeq (Sweating) to Control the Progress of Samane Mufrat (Overweight/Obesity) – A Study
Abstract: Samane Mufrat (obesity) is a chronic and increasingly common disease characterized by excess body fat. It occurs due to decrease in hararate ghareezia (innate heat). It is more prevalent in women because of their barid mizaj (cold temperament). The shaham wa sameen (fats) are barid ratab (cold wet), so they accumulate in barid mizaj individuals. A loss of 5% to 10% of body weight of obese has been shown to …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 1, Issue 1-3, 2012 · pp. 72–76 Read article