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218 articles for “Drug toxicity”
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Applications of Nanotechnology in Advanced Cosmeceuticals
Abstract: Nanotechnology is the study and manipulation of atoms and molecules on the nanoscale, which is approximately 80,000 times smaller than the width of a human hair. By 2015, the global market for products incorporating nanomaterials is projected to reach $2.6 trillion. This field showcases significant progress in research and development by improving product performance and introducing innovative solutions.The usage of cosmetics has increased significantly throughout time, and they are thought …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 1, 2025 · pp. 8–16 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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A Research on the Additives and Regulatory Requirements for Pediatric Formulation
Abstract: These days, pediatric considerations are incorporated early on in the creation of new medications. The guidelines and policies of European drug regulatory bodies served as the foundation for our investigation. The review comprehensively outlines excipients commonly found in pediatric medicine formulations. It identifies potentially harmful compounds flagged by scientific literature, stressing the necessity of rigorous safety checks, often involving toxicity studies. Excipients included in pediatric databases, like the STEP database, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 28–45 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article
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Medicinal Properties of Oxytenanthera abyssinica: A Narrative Review
Abstract: Oxytenanthera abyssinica, a plant local to the African landmass, has gotten a parcel of intrigued in later a long time for its conceivable restorative benefits; it has been utilized in conventional medication for decades since of its assumed mending capabilities. In spite of its long history, careful logical examination into its restorative potential is being attempted. This review paper explore into the multidimensional part of O. Abyssinica is in progressed …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 · pp. 21–42 Read article
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Development of Polymersomes as Macromolecular Platforms for Nanomedicine
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymersomes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2–50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows predictability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 71–89 Read article
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Development of Antioxidant Based Therapeutics in Unani System of Medicine
Abstract: During the last decades, several studies have examined the potential role of oxidative stress in the development of various diseases like cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, myocardial infarction, chronic fatigue syndrome etc. Oxidative stress can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Unani system of medicine has a wealth of antioxidants that can …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 5, Issue 3, 2018 · pp. 1–4 Read article
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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Development and Validation of Simple UV-Spectrophotometric Method of Quantization of Domperidone in Solid Dosage Formulation using Mixed Solvency Concept
Abstract: Organic solvents are most frequently employed in spectrophotometric analyses. They may be the sources of pollution. Some of them may be toxic, while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Domperidone by the use of mixed solvency concept. Domperidone shows maximum absorbance in the concentrations range of 10–50µg/ml at 287 nm. Method of analyses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 2, 2017 · pp. 19–23 Read article
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Self-Healing Polymer Composites for Pharmaceutical Packaging Applications
Abstract: Pharmaceutical packaging plays a crucial role in ensuring the safety, stability, and effectiveness of pharmaceutical products. Conventional polymer-based packaging materials are prone to mechanical damage, microcracks, and environmental degradation, which can compromise drug integrity. Self-healing polymer composites (SHPCs) offer a promising solution by enabling autonomous or stimuli-responsive repair mechanisms that restore packaging integrity, enhance durability, and extend product shelf life. These materials function through intrinsic mechanisms, such as dynamic covalent …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 648–658 Read article
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Halloysite nanotubes – A novel reinforcing material for future applications
Abstract: The distinctive nano materials such as nano powder, nano fluids, nano tubes, nano rods, nano particles, nano fibres and so forth are used in the field of nanotechnology. These nano materials are toxic in nature so not viewed as safe for people and for nature too. Halloysite nano tubes (HNT) are eco-friendly, naturally occurring cheaply available kaolinite group mineral. HNT incorporated materials have good in strength, thermal resistance and freely …
Published in Journal of Polymer & Composites · Vol. 7, Issue 1, 2019 · pp. 34–40 Read article
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The New Dimension of Cancer: It is Not a Disease but a Deficiency of Vitamin B17
Abstract: Most commonly used an alternative drug in the treatment of tumor in the last 40 years is Amygdalin. Treatment based on the use of Vitamin B-17, proteolytic pancreatic enzymes, immunostimulants, vitamin and mineral supplements for cancer is a metabolic therapy which is nontoxic. National Cancer Institute is unsuccessful to prove that Laetrile is ineffective and toxic during their studies by clinical trials in 1981. Today, position on the "front lines" …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 3, 2018 · pp. 34–36 Read article
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Toxicological Examination of Dopamine's Involvement in Substance Abuse: An Overview
Abstract: Dopamine, classified as a catecholamine, is an essential organic compound that plays a crucial role in the brain's reward system and regulatory processes. It is instrumental in reinforcing pleasurable activities through repeated engagement. Acting as a neurotransmitter, dopamine is released in various brain regions, including the striatum and accumbens, and is absorbed by neurons through receptors.This review aims to comprehensively outline the mechanisms of dopamine release and its pivotal role …
Published in Research and Reviews: A Journal of Toxicology · Vol. 13, Issue 3, 2023 · pp. 22–25 Read article
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Nanotechnology in Surgical Drains: Reducing Infections and Promoting Healing Post-Surgery
Abstract: Surgical drains are widely used in postoperative care to evacuate accumulated fluids, minimize dead space, and reduce complications such as hematoma and seroma formation. Despite their clinical importance, conventional drains are frequently associated with retrograde bacterial migration, biofilm formation, and increased risk of surgical site infections (SSIs), which contribute significantly to postoperative morbidity and prolonged hospital stay. Recent advancements in nanotechnology have enabled the development of nano-functionalized surgical drains with …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 2, 2026 · pp. 54–67 Read article
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A Review on Gold Nano Particles in Drug Delivery
Abstract: Gold Nano particles are used in several applications like drug transfer and gene etc. due to nontoxic carriers. The gold core imparts stability in these systems. The monolayer tunes the surface properties like charge and hydro-phobicity. Gold Nano particles are widely used in various applications owing to their exclusive visual, chemical and biological properties. Surface Plasmon Resonance is the attractive features of gold Nano particles. Here using the gold Nano …
Published in Trends in Drug Delivery · Vol. 5, Issue 3, 2018 · pp. 31–34 Read article
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Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats
Abstract: This research investigated the antitrypanosomal effects of Zingiber officinale in rats infected with Trypanosoma brucei brucei. Twelve adult rats, 7 weeks old and of both sexes, were randomly divided into six groups (1 through 6), with each group consisting of two rats. All six groups (1–6) were intraperitoneally injected with 0.1 ml of blood containing 10⁶ Trypanosomes/ml. Groups 1–4 received daily intraperitoneal doses of the plant extract at concentrations of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 1, 2025 · pp. 32–37 Read article
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Development and validation of a method for simulataneous determination of tenovifir disoproxil fumarate emtriculabine and isonized in bulk and pharmaceutical dosage form using RP-HPLC with relevance to toxicological aspects
Abstract: Hence, proposed analytical methods are simple, novel, economical, rapid, sensitive, reproducible and accurate for the Simultaneous estimation of Tenofovir Disoproxil Fumarate, Emtricitabine and Isoniazid in Bulk and Phamaceutical dosage form by using RP- HPLC. This Method gives reliable assay results with short analysis time using mobile phase of Acetonitrile : 0.02M Potassium Dihydrogen Orthophosphate: water (pH 5.3) in the ratio of 60: 25: 15 respectively. Retention time was found to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 17–25 Read article
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Comparative Study of Cardiac Poisons in Ayurvedic and Modern View
Abstract: The concept of Visha is widely used in Ayurveda in different dimensions such as a poisonous drug, synonym of fast acting drugs, anything that creates Vishaada (sadness to mind and body by causing different diseases). Poisons are also used as a constituent in various multidrug formulations. So, it becomes necessary to use this poison judiciously for the benefits of human race. Certain drugs are known for their actions on heart. …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 6, Issue 2, 2019 · pp. 1–6 Read article
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Silver Nanoparticle as Antiviral Agent and Its Uses
Abstract: Silver had been used by human thousands of years ago as various types of medicines (RasaratnaSamuccahay, Bhagbhatta). As the years passes more scientific uses of silver metals had been seen as the human civilization progresses.After the discovery of nano technology Silver is being used in a variety of ways .Nano particles exhibits less toxicity as compared to their ionic counterpart. Nowadays silver is used in various forms colloidal silver Nanoparticle …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 22, Issue 1, 2020 · pp. 28–34 Read article