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171 articles for “Drug release study”
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Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs
Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article
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Maximizing In Situ Formulation Adhesion Potential By Testing Different Polymer
Abstract: This study explores the use of a in-situ ocular gel delivery system for gentamicin sulphate. The anatomy of human eye consists of the cornea, lens, aqueous humor, vitreous humor, and retina. The physiology of the human eye involves the production of tears and the process of accommodation. Eye infections are caused by viruses, fungi, bacteria, or parasites. The symptoms of eye infection can include redness, itching, burning, watering, discharge, and …
Published in Trends in Drug Delivery · Vol. 10, Issue 1, 2023 · pp. 1–10 Read article
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Polymeric Micelles for Medicinal Plant Solubilization and Delivery of Bioactive Compounds
Abstract: This study involved the design, fabrication, and characterization of polymeric micellar nanocomposites utilizing amphiphilic block copolymers to effectively encapsulate and transport hydrophobic phytoconstituents. The selected bioactive molecule is curcumin, a polyphenol with limited water solubility. A polymeric system known as PEG-PCL was utilized to fabricate core-shell nanostructures by a solvent evaporation-induced self-assembly method. The resulting nanocomposites exhibited homogeneity and colloidal stability, characterized by a zeta potential of −18.7 ± 1.4 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 208–219 Read article
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Polymer Chemistry in Sustained-Release Herbal Composites: Designing a Stable Euphorbia tithymaloides Topical System with Phospholipid and Polymer Matrices
Abstract: Polymer chemistry enables the stabilization and sustained release of herbal actives, critical for topical therapeutic applications. This study explores a novel process for preparing a stable, sustained-release topical composition of Euphorbia tithymaloides, leveraging polymer-based systems. Ethanolic extract (50 mg) of the plant, rich in unstable sugar moieties (e.g., D-ribose) and sterols (e.g., stigmasterol), is encapsulated within a phospholipid matrix of phosphatidylcholine (50–100 mg) and cholesterol (50–100 mg). This lipid-polymer complex, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 165–171 Read article
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Liquid Crystals as Novel Drug Carrier: A Review
Abstract: Liquid crystal is a thermodynamic stable phase characterized by anisotropic properties, generally lying in the temperature range between the solid and isotropic liquid phase, hence are termed mesophase. Based on the way that liquid crystals are obtained, they can be classified into two types—thermotropic liquid crystals and lyotropic liquid crystals. The thermotropic liquid crystal is generated by variation of temperature in the liquid state, while the lyotropic liquid crystal is …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 1–9 Read article
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Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation
Abstract: This study had the goal to formulate oral polymeric thin film that would dissolve and disintegrate instantly, while also having high mechanical features. These are the most advanced forms of solid dosage forms. Solvent casting was the technique employed to create oral thin films. These are additionally referred to as buccal films/strip, mouth dissolving films, oral thin films, as well as oral strips of paper. These films are suitable for …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 1–6 Read article
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Innovative strategies in capsule formulation from concept to market
Abstract: Innovative strategies in capsule formulation have revolutionized drug delivery and nutraceutical development, offering advanced solutions from initial concept to market release. This report explores the transformative techniques at each stage of capsule formulation, detailing novel approaches in ingredient selection, encapsulation technology, and manufacturing processes. By leveraging advancements in artificial intelligence, encapsulation methods, such as liposomal and nanoparticle technologies, and materials science, formulators can optimize the bioavailability, stability, and targeted delivery …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Monophase Solution for Enhancing Solubility and Dissolution of Ezetimibe by Spray Dried Microparticle
Abstract: The aim of the present study was to improve the solubility and dissolution rate of Ezetimibe by preparing crystals by spray drying technique using Isopropyl alcohol (IPA) and water as solvent system. Ezetimibe crystals were produced by spray drying using IPA as solvent to enhance solubility and dissolution rate. The prepared crystals were evaluated for solubility and in vitro dissolution. The prepared formulations were characterized by differential scanning calorimetry (DSC), …
Published in Trends in Drug Delivery · Vol. 1, Issue 3, 2014 · pp. 30–36 Read article
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The Reaction About Anti-Hypertensive Drugs According to Plasma Renin-Aldosterone States
Abstract: With recent studies, hypertension has not only a simple pathophysiology, thus it can classify details more about and establishing drug therapy strategies compatible with it is a very important method to improve the organ predictive of patients. The purpose of this study is to compare the responsibility of some anti-hypertensive drugs in hypertensive patients according to plasma renin-aldosterone levels, which becomes the background factor of hypertension. We investigated 71 hypertensive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 14–23 Read article
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A Brief Review on Herbal Excipients
Abstract: Natural or herbal excipients are significantly more advantageous than their synthetic equivalents because they are readily available, non-toxic, and less expensive. The pharmaceutical industries are becoming more interested in using these herbal excipients – mainly polymers of natural origin – in formulation development because of growing knowledge of them. The purpose of this study is to provide light on the possibility of using natural excipients, which are biocompatible and able …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 2, 2025 · pp. 5–14 Read article
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Bioconjugates and Biohybrid Polymers: Intricate Cellular Integration Methods and Sophisticated Biofunctionalization Techniques for Tailored Properties in Medical Contexts
Abstract: Bioconjugates are made when biological molecules are covalently linked to manufactured polymers. They can be used in many ways for imaging, diagnosis, and specific drug delivery. Getting perfect cellular fusion is very important for how well they work. Biomolecules can be attached to polymer scaffolds in a controlled way using techniques like click chemistry and site-specific conjugation. This makes sure that the molecules connect optimally with their biological targets. Using …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 227–243 Read article