Maximizing In Situ Formulation Adhesion Potential By Testing Different Polymer

Ravindra Singh; Ayushi Tyagi; Ujjwal Bharti; Pratibha .; Manasvi Saini

doi:10.37591/tdd.v10i1.1263

Abstract

This study explores the use of a in-situ ocular gel delivery system for gentamicin sulphate. The anatomy of human eye consists of the cornea, lens, aqueous humor, vitreous humor, and retina. The physiology of the human eye involves the production of tears and the process of accommodation. Eye infections are caused by viruses, fungi, bacteria, or parasites. The symptoms of eye infection can include redness, itching, burning, watering, discharge, and pain. Types of eye infections include bacterial conjunctivitis, viral conjunctivitis, blepharitis, and keratitis. In-situ gelling formulation is a system of drug delivery composed of a hydrophilic polymer that can form a gel when exposed to an aqueous environment. The importance of this system is that it can provide a sustained drug release to the targeted area. The approaches to in-situ gelling systems include pH-responsive, temperature-responsive, and ion-responsive systems. The application of in situ formulation includes ophthalmic delivery and other topical drug delivery. This paper investigates the potential of different polymers, such as chitosan, HPMC k4M, HPMC e50LV, carbopol 934, and methyl cellulose, to maximize in situ formulation adhesion.. The results indicate that certain polymers are more suitable for particular substrates and thus can be used to maximize in situ formulation adhesion potential. The research findings can be used to help determine the best polymer for a particular substrate, which will help to maximize the adhesion potential of the formulation.