Search
556 articles for “Formulation”
-
Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
-
Strategic Enhancement of Composite Strength Explored Through Comprehensive Integration of Flax Fiber and Cenosphere in Epoxy Resin Matrices
Abstract: The Current research delves into the mechanical attributes of composite specimens, integrating flax fiber and cenosphere fillers within an epoxy resin matrix catalyzed by K-6 hardener. Executing a meticulous approach involving a vacuum bagging method and a specific formulation of 10 wt.% cenosphere, 50% epoxy resin, and 40% flax fibers, the study rigorously scrutinized tensile and flexural strengths. Notably, the first specimen exhibited a peak tensile strength of 94.329 MPa, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 199–217 Read article
-
A Comprehensive Review of Ayurvedic Pharmaceutics in Charaka Samhita W.S.R to Chikitsasthana.
Abstract: Charaka Samhita provides insightful information on the holistic approach to well-being by addressing every facet of health, from illness management to preventive measures. It is organized into eight Sthana, and is filled with information on anatomy, physiology, disease etiology, diagnosis, treatment, and health maintenance principles. The term "Charakastu Chikitsite" denotes that Charaka Samhita is the greatest treatise on Ayurvedic therapeutics. Numerous subjects related to diagnosis, treatment planning, and disease management …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 1, 2024 · pp. 14–25 Read article
-
Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
-
Enhancing Peptic Ulcer Therapy: Innovations in Mucoadhesive Drug Delivery
Abstract: Peptic ulcer disease is still a sincere gastrointestinal demand makes medication administration difficult because of the harsh and changing stomach environment. This paper investigates the potential of using mucoadhesive drug delivery devices to improve the accuracy and effectiveness of peptic ulcer therapies. Due to the inherent characteristics of mucoadhesive drug delivery systems, localized and sustained drug release is made possible by their extended contact and adherence to the gastrointestinal tract's …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 62–76 Read article
-
Review of Ayurvedic Drugs on Acid-peptic Diseases Regarding Its Personalized Management
Abstract: Acid-peptic Disease (~Amlapitta) is an illness wide-spread all around the world. In Ayurveda, Vidahi (which cause burning) and Pitta (dosha responsible for metabolic activities) aggravating diet and stressful –sedentary life-style has been stated as one of the leading cause for acceleration of Amlapitta. Detailed reviewing of drugs given in Ayurvedic texts are done according to specific stage of disease, Amlapitta Dosha predominance, chronicity, associated conditions, dosage, Anupana etc. Screening the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2024 · pp. 24–38 Read article
-
Factors Affecting Shear Stress on Tablet Hardness and Disintegration
Abstract: The quality and effectiveness of pharmaceutical tablets depend heavily on several factors influencing shear stress on tablet hardness and disintegration. These factors include formulation composition, wherein the selection and concentration of excipients and active ingredients affect how the tablet material responds to shear stress. Additionally, the compression force, speed, and duration during tablet compression are critical, impacting tablet hardness and disintegration properties. Tablet geometry and design, along with tablet press …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 1–19 Read article
-
The Creation and Assessment of the Herbal Face Pack
Abstract: The aim of this study is to develop and test herbal facials for glowing skin using organic herbs. Natural herbal components in the form of dry powder, such as Orange peel, Tulsi (Holy Basil), Masoor dal (Lentin), Multani mitti (Calcium Bentonite), and Methi (Fenugreek), Sandalwood (Santalum album) were bought from the local market. Orange peel powder was made via commercial shade drying. To guarantee a consistent composition, all powdered natural …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 2, 2024 · pp. 13–25 Read article
-
Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
-
Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
-
Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
-
A Comparative Analytical Study on Gandhaka Ointment Prepared by Two Different Oleaginous Bases – As a Thesis Article
Abstract: Gandhaka (purified sulphur) is broadly used in Ayurvedic dermatological preparations, particularly in Malahara Kalpana (ointment formulations), due to its well-known antimicrobial and skin-healing properties. Although classical Ayurvedic texts, such as Rasa Shastra and Bhaishajya Kalpana, do not directly mention Gandhaka ointment, Rasatarangini by Acharya Sadanand Sharma describes four discrete methods for preparing Gandhaka Taila (sulphur-infused oil). In this study, the third method was selected to prepare Gandhaka Taila using two …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 27–39 Read article
-
AI-Driven Multi-Objective Optimization of Conductive Polymer Composites for High-Performance Flexible Electronics
Abstract: The development of conductive polymer composites (CPCs) is critical for advancing flexible and wearable electronic technologies. However, the conventional trial-and-error approach to material formulation is time-consuming and often inefficient due to the high-dimensional nature of the design space. This study introduces a novel AI-driven framework that integrates machine learning (ML) with multi-objective optimization to accelerate the discovery of high-performance CPCs. A dataset of 1,000 experimentally reported formulations was compiled, capturing …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 734–745 Read article
-
Evaluation of Mucoadhesive Polymers for Nasal Delivery of Herbal Bioactives
Abstract: A study assessed mucoadhesive polymers for intranasal herbal bioactive administration with higher residence time and mucosal permeability. Chitosan, Carbopol® 934P, and HPMC K15M were utilized to manufacture mucoadhesive nasal gels with standardized herbal bioactive fractions. Formulations were examined for pH, viscosity, spreadability, drug content, mucoadhesive strength, in-vitro release, ex-vivo penetration, and short-term stability. All formulations demonstrated a suitable pH for nasal usage and uniform drug content (97.48 ± 1.12% to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1680–1689 Read article
-
Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Development and Evaluation of Medicated Mouth Wash
Abstract: The present invention is to formulate and evaluate a novel medicated mouth rinse using Achyranthes aspera extract in an oil-based formulation. The herb Achyranthes aspera, which has long been used for medicinal purposes, was chosen because of its purported anti-inflammatory and antibacterial qualities. This study aimed to create a safe, effective, and pleasant-tasting mouth rinse to maintain oral hygiene and address common oral health issues. Achyranthes aspera’s bioactive components were …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 21–30 Read article
-
Polymeric Emulsion Composite System Enriched with Eggshell-Derived Biominerals for Dermal Delivery
Abstract: This study describes the development and characterization of a sustainable polymeric water-in-oil (W/O) emulsion composite designed for dermal delivery and skin repair applications. The formulation was prepared using a lipid-rich biopolymeric matrix containing glyceryl stearate, beeswax, and plant-derived ingredients, which acted as the continuous phase for stabilizing and dispersing inorganic mineral fillers. Eggshell waste was utilized as a natural calcium source and combined with magnesium and zinc oxide to create …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Artificial Intelligence-Assisted Multi-Objective Optimization of Agricultural Biomass-Reinforced Polymer Composites
Abstract: Agricultural biomass can reduce the environmental burden of polymer composites, yet its heterogeneous structure creates competing effects on strength, moisture resistance, density, and process ability. This study developed an artificial intelligence-assisted framework for balanced composite formulation. Experimental data of agricultural biomass reinforced polymer composites were gathered, harmonized and validated using leakage controlled validation. The mechanical and physical properties were predicted by artificial neural networks and conventional regression models. Explainable analysis …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Recent Advances in Delivering Strategies of Domperidone Challenges and Opportunities
Abstract: Domperidone (DMP), a potent gastroprokinetic and antiemetic drug, exhibits poor aqueous solubility and limited oral bioavailability. Therefore, to develop oral preparations with optimized oral bioavailability, the pharmacokinetic parameters of DMP need to be controlled. The present review aimed to discuss the physicochemical characteristics of DMP causing its unfavorable oral delivery, to explore the viable oral formulation approaches, and to propose some recent formulation approaches that can mitigate the above mentioned …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 13–24 Read article
-
Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article