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559 articles for “and Toxicity.”
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Arsenic Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 16–37 Read article
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Rotenone Beyond Just An Insecticide: A Review
Abstract: Pesticides have received the most attention due to their global application and widespread implications on human health. In recent years, both epidemiological and toxicological studies have provided evidence that pesticides have the potential to act as toxicants contributing to the development of pathogenesis such as neuronal degenerations as well as may be utilized to induce signalling for reversal, suppress or prevent carcinogenic progression. Rotenone, an isoflavones naturally found in the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 2, 2014 · pp. 8–13 Read article
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Impact of Hexavalent Chromium on Histopathology in Freshwater Stinging Catfish Heteropneustes Fossilis
Abstract: Acute toxicity of Cr (VI) (as K2Cr2O7) to freshwater stinging catfish, Heteropneustes fossilis and its histopathological impacts on gill and liver tissue were evaluated. Fish showed behavioral alterations after K2Cr2O7 exposure and 96 h-LC50 was 35.724 mg/L in static bioassay. Fish were exposed to three sub-lethal concentrations (concentration I=1/4th of 96 h-LC50, concentration II=1/10th of 96 h-LC50 and concentration III=environmental concentration of Cr reported in the river Buriganga). Blood, liver …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 12–19 Read article
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Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of the Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 7–34 Read article
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Paraphenylenediamine Poisoning: A Review of Literature
Abstract: Any substance dangerous to living organisms when either applied internally or externally, destroy the action of vital functions or prevent the continuance of life is known as poison. Cosmetics, medicines, and other household items could lead to a serious poisoning if accidently consumed by children. The home environment is the primary location of most poisonings, with over 90% of reported poisonings occurring at home. Most non-fatal poisonings occur in children …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 17–24 Read article
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Hakim Ismail Jurjani (1042–1137 AD): Life, Works, and Medical Legacy
Abstract: Hakim Ismail Jurjani, also known as Seyyed Isma’il Jorjani, was among the most distinguished physicians and scholars of medieval Persian medicine whose contributions significantly influenced the development of Greco-Arab and Unani medical traditions. His monumental encyclopedia, Zakhīra Khwārazmshāhī (Treasure of the Khwarazm Shah), is regarded as one of the greatest medical compilations of the Islamic Golden Age and represents a landmark in the evolution of Persian scientific literature. Unlike earlier …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 · pp. 31–36 Read article
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Assessment of Hepatic Damage in Labeo rohita (Hamilton, 1822) Exposed to Azo dye C. I. Direct Green 6
Abstract: Textile industries are one of the major backbones of Indian economy. They are the major reason for contamination of water bodies and their toxicity to ecosystem is an alarming environmental issue. The present study was designed to evaluate the hepatotoxic effects of C.I. Direct Green 6 (DG 6), a commercially used textile azo dye on Labeo rohita fingerlings. For this, L. rohita fingerlings were exposed to three sublethal concentrations (2.5, …
Published in Research and Reviews : Journal of Veterinary Science and Technology Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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Urban Eye: Manhole Surveillance with IoT
Abstract: Every nation hopes to implement the idea of the "smart city" on its own. Many different issues must be resolved in order to grow the seed into a large tree. The drainage system is one of them, and it is essential. With the right drainage system, even a tiny region can make a significant contribution to society. A sewer system can be accessed through manholes. Manholes are the best approach …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 1, Issue 1, 2023 · pp. 13–22 Read article
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Evaluation of the anti diabetic effects of ethanolic root extract from polyalthania longifora in diabetic rats induced by streptozotin and nicotinamide with considaertion of toxocological aspects
Abstract: The root of Polialthia Longifolia was selected for the evaluation of antidiabetic potential in STZ-nicotinamide induced diabetic rat model.The root extract was extracted by hot percolation using ethanol as a solvent in soxhlet apparatus and the preliminary phytochemical screening was performed and it shows that the ethanolic root extract of Polialthia Longifolia contains alkaloids, glycosides, flavonoids and tannins. Safety profile is essential for the drugs obtained from the plant origin. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 37–50 Read article
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Strategies in the Delivery of Nonsteroidal Antiinflammatory Drugs
Abstract: Non-steroidal anti-inflammatory drugs [NSAIDs]. are widely used for the management of pain, inflammation, and fever. However, their effectiveness is often limited by gastrointestinal side effects such as ulceration and bleeding, as well as systemic complications including renal toxicity and cardiovascular risks. To address these challenges, various strategies have been developed to improve the delivery of NSAIDs, aiming to enhance their therapeutic efficacy while minimizing adverse effects. This abstract provides an …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 44–61 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Contribution, Limitations and Future Of Plant Growth Promoting Consortium in Sustainable Agriculture
Abstract: Current agricultural methods rely significantly on chemical fertilizers, pesticides, and other agrochemicals to enhance plant growth and combat pathogens, aiming to boost crop yields. However, the accumulation of chemical residues in the soil diminishes soil fertility considerably over a period. These accumulated chemicals gradually alter the soil's chemical composition, ultimately rendering it infertile. The high-risk conditions associated with these agricultural chemicals such as bioaccumulation, chemical toxicity and development of resistance …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 2, 2024 · pp. 29–51 Read article
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Heavy Metals Contamination in Groundwaters of Punjab: A Man-made Curse and its Mitigation
Abstract: The curse of heavy metal contamination in groundwaters of Punjab state is causing health hazards for the population of Punjab. It is not so much a natural disaster as its origin can be traced to a man-made crisis in Punjab. Potentially toxic elements, including high levels of Uranium (U) contamination in the Malwa belt of Punjab, Arsenic contamination in the Majha belt, and Selenium contamination in the Doaba belt of …
Published in Journal of Water Pollution & Purification Research · Vol. 11, Issue 1, 2024 · pp. 6–22 Read article
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Exploring the Synergistic Effects of Heavy Metal contaminants on Aquatic Organisms
Abstract: Human activities have a profound effect on aquatic habitats by altering water and sediment quality, which in turn impacts resident organisms. These changes are primarily caused by pollutants from agricultural, industrial, and health-related sources. Industrial effluents, often containing hazardous heavy metals such as chromium, manganese, and lead, are a major source of environmental toxicity. The discharge of these pollutants makes water unsafe for drinking, irrigation, and industrial uses, necessitating effective …
Published in International Journal of Marine Life · Vol. 1, Issue 2, 2024 · pp. 17–20 Read article
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Role of biosynthesized Copper nanoparticles in Agriculture and other fields
Abstract: In the last decades, nanotechnology has emerged as a new field of technology because of its unique qualities. The use of chemicals in medicines and agriculture such as fertilizers, pesticides, herbicides, and insecticides are very harmful to the environment so by the use of this revolutionary technology we can reduce the toxic effects on the environment. However, a biological method is very easy, simple, and free from any chemical hazards, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 2, 2024 · pp. 39–53 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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A Review on Heavy Metal Removal Techniques in Water Treatment
Abstract: The removal of heavy metal ions from wastewater is crucial for environmental safety and human health due to the toxic and persistent nature of these pollutants. This review comprehensively examines various water treatment methods, including adsorption, membrane filtration, chemical precipitation, electrochemical, and photocatalytic processes. Each technique is critically analyzed in terms of removal efficiency, operating conditions, and their respective advantages and limitations. Adsorption methods, particularly those using bioadsorbents, have gained …
Published in Journal of Water Pollution & Purification Research · Vol. 11, Issue 3, 2024 · pp. 15–28 Read article