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191 articles for “Pharmaceutical activities.”
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Synthesis, Characterization of New Imidazolidin-4-One Containing Azo Compound Derived from Acetylacetone as Antibacterial and Antioxidant Agents
Abstract: In the present study, new derivatives of imidazolidine-4-one was prepared. Which involved reactions to diazonium salt of o-methoxy aniline with acetylacetone in the presence of sodium hydroxide, and isolating the azo compound as a brown precipitate. The azo diketone reacts efficiently with aromatic amine derivatives to produce Schiff bases as a light yellow and dark brown precipitates, and from this Schiff bases three derivatives of imidazolidine-4-one was prepared by reacting …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 94–114 Read article
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Organic Solvent Tolerant (OST) Lipases, Sources and Industrial Applications
Abstract: Enzymes are natural catalysts. Lipases are used widely and have property of performing reaction in aqueous as well as organic solvents. Absolutely, in the recent times, there has been continuous increase in the number of publications, regarded properties and industrial applications of lipase catalyzed reactions. Lipases form an essential part of the industries ranging from food, dairy, pharmaceuticals, agrochemical and detergents to oleo-chemicals, tea industries, cosmetics, leather and in a …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 32–42 Read article
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Aureobasidium pullulans- The Versatile Microcolonial Fungus for Industrial Production of Natural Products
Abstract: Aureobasidium pullulans, a yeast-like fungus, exhibits a remarkable capacity for synthesizing an extensive array of bioproducts with diverse industrial applications. This fungus is known to survive in several environmental conditions, making it a robust organism for biotechnological processes. The organism is characterized by its adaptability to various environmental conditions and habitats. It produces an array of extracellular enzymes such as amylases, lipases, proteases, and pectinases, contributing to its role as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 1, 2024 · pp. 19–31 Read article
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Influence of Antibiotic Promotion Practices on Pharmacovigilance and Resistance Reporting Patterns
Abstract: The global escalation of antimicrobial resistance (AMR) has emerged as a critical public health crisis, undermining decades of therapeutic advancements. While inappropriate prescribing and misuse of antibiotics are widely acknowledged contributors, the role of pharmaceutical promotion practices remains underexplored in influencing prescribing behaviors and downstream pharmacovigilance systems. This review critically examines how antibiotic promotion strategies – ranging from direct physician engagement to digital marketing – affect adverse drug reaction (ADR) …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 1–11 Read article
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3D QSAR Studies of 2,3-Disubstituted Quinazolin Phenyl Acetic Acid Derivatives as Antimicrobial Agents
Abstract: Quantitative structure activity relationship (QSAR) studies have been performed on series of31 compounds of 2,3-disubstituted quinazolin phenyl acetic acid derivatives withantimicrobial activity using Chemoffice version 8.0 software. The QSAR models have beendeveloped by using multiple linear regressions in order to identify descriptors, which areactually focusing towards the biological activity. Leave one out (LOO) method was employedin cross validation analysis to validate the developed model. The best predictive QSAR modelderived, had …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 4–7 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 10–25 Read article
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Screening of Pharmaceutically Significant Methioninase-Producing Fungi from the Satpura Range of Hoshangabad District and Its Large-Scale Production
Abstract: L-methioninase, an enzyme with notable anticancer properties, has emerged as a promising therapeutic agent due to its ability to selectively degrade methionine, a critical amino acid for the survival of methionine-dependent cancer cells. Methionine dependency, observed in many tumor cells, is a metabolic vulnerability that can be exploited for targeted cancer therapy. The Satpura Range in the Narmadapuram District, India, with its diverse microbial ecosystems, offers a rich reservoir for …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 33–43 Read article
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Consumer Misuse of Cosmeceuticals and Its Role in Adverse Skin Reactions
Abstract: Cosmeceuticals represent a rapidly expanding category of products positioned between cosmetics and pharmaceuticals, offering both aesthetic and therapeutic benefits. However, their widespread availability, aggressive marketing, and perception as inherently safe have contributed to increasing instances of consumer misuse. Misuse includes over-application, inappropriate combinations, prolonged unsupervised use, and use of high-potency active ingredients without dermatological guidance. Such practices have been strongly associated with a broad spectrum of adverse cutaneous reactions ranging …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 · pp. 1–16 Read article
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The Development and Characterization of Orodispersible Tablet using Novel Natural Superdisintegrant Polysaccharide Isolated from Cassia tora Seeds
Abstract: The present work is aimed at the development and characterization of orodispersible tablet using novel natural super disintegrant, a polysaccharide isolated from Cassia tora seeds. Metformin hydrochloride (HCL) tablets were prepared separately using different concentration (2%, 5%, 7.5%) of isolated Cassia tora seed, a natural polysaccharide and croscarmellose sodium (synthetic) as super disintegrant by direct compression method. Evaluation of the tablet was done for various pre and post-compression parameter. Development …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 24–31 Read article
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Activity of Cannabinoids in Type II Diabetes
Abstract: The present research is a theoretical study of the medicinal use of Cannabis (cannabinoids) compounds in Type II Diabetes based on literature citing animal models and available clinical evidence from human studies. The study emphasizes the positive physiological actions and benefits of cannabinoid compounds in Type II Diabetes. The pharmacological activities of cannabinoid compounds in Type II Diabetes have been studies only in limited human clinical trials that were often …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 2, 2017 · pp. 1–5 Read article
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Simple, Direct and Stability-Indicating UV Spectrophotometric Assay of Pioglitazone Hydrochloride in Pharmaceuticals
Abstract: Pioglitazone hydrochloride (PGH) is an antihyperglycemic agent used in the treatment of type-2 diabetes mellitus. A simple and straight forward UV-spectrophotometric method is presented for the determination of PGH in bulk drug and tablets by measuring the absorbance of drug solution in 0.1M H2SO4 at 269 nm. A plot of absorbance versus concentration obeyed Beer’s law over 2–36 µg ml-1 concentration range (r = 0.9981) with a molar absorptivity of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 7–16 Read article
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Pain Management in Rheumatoid Arthritis: Clinical Role and Therapeutic Implications of NSAIDs
Abstract: Rheumatoid arthritis (RA) is a progressive, chronic autoimmune condition that results in swelling in multiple joints. It is estimated to occur in 0.5–1% of the global population and is more common in women. India has an estimated prevalence of 0.75%. RA causes the destruction of joints and a decrease in disabilities and quality of life. It is accompanied by further manifestations and multiple co-occurring conditions that lead to a greater …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 4, Issue 1, 2026 · pp. 21–27 Read article
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A Comprehensive Review on Chitosan Anticancer Property
Abstract: Chitosan, a hydrophilic, natural amino polysaccharide derived from chitin on alkaline de-acetylation. Chitosan is a nontoxic, biocompatible, antibacterial and biodegradable polymer. The biological activities of chitosan are mainly depending on the water solubility nature and also the solubility in other solvents. The primary amino group present in the chitosan is the key functional groups which is mainly responsible for its bioactivities. The biological activities of antimicrobial, antioxidant and anticancer properties …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 2, 2020 · pp. 1–7 Read article
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Comprehensive Review on Pulsatile Drug Delivery System: Hybrid Approaches
Abstract: Pulsatile drug delivery systems (PDDS) represent a groundbreaking approach in pharmaceutical technology, allowing for controlled, targeted, and programmable drug release that aligns with circadian rhythms or caters to time-sensitive therapeutic requirements. Although traditional pulsatile systems have shown considerable clinical promise, their effectiveness is frequently compromised by physiological variations such as gastrointestinal transit times, changes in pH, and enzymatic activity. To tackle these obstacles, hybrid PDDS have been developed by combining …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 18–31 Read article
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Anti-infective Investigations of Methanolic Extract and Petroleum Ether Extract of Ixora coccinea L. Flowers
Abstract: Ixora is an evergreen flowering tropical plant belonging to the family Rubiaceae. It is commonly found in India, the United States of America, Africa, South East Asia, and Southern Asia. Across the globe, several species (Ixora coccinea, I. parviflora, I. chinensis, I. macrothyrsa, I. javanica, and I. finlaysoniana) of this genus have been identified so far. After going through the literature available in pharmaceutical databases, it was found that the …
Published in Research & Reviews : Journal of Botany · Vol. 9, Issue 2, 2020 · pp. 17–23 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
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Unveiling the Role of Lead Molecules in CADD: A Systematic Review
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Synthesis and characterization of mixed SnO2-ZnO Nano composites material to study the kinetics of catalytic reduction of Aromatic Nitro compounds
Abstract: A straightforward and cost-effective method was employed to synthesize zinc oxide (ZnO) nanostructures supported on tin oxide (SnO₂) for catalytic applications. This hybrid nanocomposite, formed by integrating ZnO with SnO₂, exhibited impressive catalytic activity in the reduction of various nitro compounds. The synergistic interaction between ZnO and SnO₂ significantly enhanced the surface area and active sites of the catalyst, thereby improving its overall efficiency. The resulting SnO₂-ZnO nanocomposite not only …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 8–14 Read article
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The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
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Chemical Patents and Filing Practices in India: Trends, Processes, and Legal Framework
Abstract: India, recognized as the fifth-largest global economy, holds the 7th position in the chemical sector and ranks 11th in chemical and petrochemical exports worldwide. Despite this significant standing, the country witnesses comparatively fewer patent applications in this domain. The global chemical and petrochemical industry, although complex in nature, serves as a critical element of economic development and supply chain operations. This paper explores the interconnectedness of innovation, patents, and chemical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 163–171 Read article