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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Utilization of Jackfruit as a Potential Supplement in Yoghurt and Evaluation of Its Nutritional and Commercial Aspects
Abstract: This study aimed to formulate fruit juice yoghurt by incorporating nutritious and flavorful jackfruit juice, known for its health benefits. Jackfruit juice was added at different levels (5%, 10%, and 15%) to yoghurt, and various chemical, microbiological, bioactive compounds, and sensory quality characteristics were analyzed. Statistical analysis revealed that panelist acceptability decreased with increasing fruit juice level. Among the samples, yoghurt with 10% jackfruit juice showed significantly different sensory characteristics …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 1, 2025 · pp. 1–14 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Mechanical and Physicochemical Characteristics of Nano-Hydroxyapatite Polymer Composites
Abstract: This study focuses on the development and characterization of nano-hydroxyapatite (nHAp)-reinforced poly (lactic acid) (PLA) composites for biomedical applications. The composites, prepared with varying nHAp content (5–25 wt%), were evaluated for their mechanical and physicochemical properties, including tensile strength, Young’s modulus, elongation at break, thermal stability, hydrophilicity, and crystallinity. Results revealed that tensile strength increased significantly with the incorporation of nHAp, reaching a peak of 62 MPa at 15 wt%, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 115–125 Read article
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Comprehending and Managing Restless Leg Syndrome
Abstract: An need to move that arises during rest or is made worse by rest, that happens in the evening or at night, and that goes away or gets better with movement is the hallmark of restless legs syndrome (RLS), a frequent sensorimotor disease. The degree, frequency, and age of start of symptoms vary greatly; severe types can impair mood, quality of life, and sleep. Periodic leg movements are common in …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 1–6 Read article
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Mind-Gut Connection: The Psychosomatic Effects of Stress and Emotions on Digestive System
Abstract: Stress, understood as an immediate disruption to bodily equilibrium, triggers an adaptive or allostatic response that impacts gastrointestinal function both in the short and long term. The enteric nervous system communicates in both directions with the brain through parasympathetic and sympathetic pathways, collectively forming what is known as the brain-gut axis. Unani scholars describe stress as a response to the loss of something valuable, such as an opportunity, a desired …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 11–14 Read article
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Synthesis and Characterization of a Naphthalene-Derived Schiff Base for Fe³⁺ Sensing Applications
Abstract: The development of chemosensors for metal ions has gained significant attention due to their crucial role in industrial, environmental, and biological applications. Metal ion detection is essential for monitoring environmental pollution, industrial processes, and biological systems where metal homeostasis plays a vital role. In this study, we focus on the synthesis, characterization, and application of a novel naphthalene-based Schiff base ligand, derived from the condensation reaction between 1,8-diaminonaphthalene and 3-nitrobenzaldehyde. …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 1–8 Read article
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CMOS-Based Process-Scalable Analog Circuits for Machine Learning: A Comprehensive Review and Future Directions.
Abstract: Analog computing techniques are gaining attention for machine learning (ML) applications due to their ability to reduce computational complexity. Continuous operations such as addition and subtraction offer a simpler and more efficient approach compared to probabilistic product decoding, which can be sensitive to noise and inconsistent measurements. This paper presents a simulated VLSI implementation of a broadcast edge connection, independent of the MOS component model, along with experimental results. The …
Published in Journal of VLSI Design Tools and Technology · Vol. 15, Issue 1, 2025 · pp. 8–17 Read article
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A Comprehensive Review of Alternative Medicine: Biological Plausibility, Testability, Repeatability, and Effectiveness
Abstract: Alternative medicine, encompassing practices, such as acupuncture, herbal remedies, homeopathy, chiropractic care, Ayurveda, and Traditional Chinese Medicine (TCM), has gained global popularity as patients seek non-conventional healthcare solutions. Despite its widespread use, scientific evaluation of its biological plausibility, testability, repeatability, and effectiveness remains a significant challenge. This review critically examines these four criteria to assess the validity and reliability of alternative therapies. Acupuncture demonstrates partial plausibility, with evidence suggesting its …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 32–46 Read article
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Comparative Analysis of Kinetic Models for Simulation of Biogas Production from Cow Dung and Fruit Waste via Anaerobic Digestion
Abstract: This study investigates the optimization of biogas and biofertilizer production from cow dung and fruit waste through anaerobic digestion, utilizing various microbial growth kinetic models. Simulations were conducted using the Monod, Moser, Contois, and Tessier models to predict biogas yield and assess model accuracy. Results indicated that the Tessier model provided the closest fit to experimental data, with a biogas yield of 0.45 m³/kg VS, while the Monod model overestimated …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 47–63 Read article
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Vertical Villages: Redefining Urban Living for a Sustainable Future
Abstract: As urbanization accelerates, cities face growing challenges in balancing population growth with sustainable resource use. Traditional horizontal sprawl is increasingly unsustainable, causing habitat loss, inefficient land use, and higher carbon emissions from long commutes and overstressed infrastructure. Addressing these issues, vertical villages offer an innovative, sustainable alternative for dense urban environments. Vertical villages are multi-story, integrated communities that combine residential, commercial, and communal spaces within compact areas. By optimizing land …
Published in International Journal of Architectural Design and Planning · Vol. 3, Issue 1, 2025 · pp. 7–17 Read article
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Enhancing The Mechanical Performance of Al6061/Graphite Composites Reinforced with Sic and Aluminium Oxide Processed by Stir Casting
Abstract: The study investigates the mechanical properties of aluminum alloy Al6061 reinforced with varying proportions of silicon carbide (SiC) (0 wt%, 4 wt%, 5 wt%, and 6 wt%) and aluminum oxide (Al₂O₃) (0 wt%, 4 wt%, 3 wt%, and 2 wt%), with a constant addition of 1 wt% graphite. The composites were fabricated using the stir casting process, an efficient and economical method for uniformly distributing ceramic reinforcements within the metal …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 66–74 Read article
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A Comparative Study of Oven, Spouted Bed, and Convective Tunnel Drying Methods of Mango for Oil Production
Abstract: Mango seeds, with a high moisture content exceeding 70% (wet basis) require effective drying methods to ensure their preservation and to enhance the quality of derivative products like mango seed oil. Proper drying is essential to inhibit enzymatic activity and microbial growth, which extends the shelf life of these seeds. This study investigates multiple drying techniques, including conventional oven drying, spouted bed drying, and convective tunnel drying, to determine their …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 1, 2025 · pp. 15–19 Read article
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Enhancing Mechanical Properties of Fiber-Reinforced Composites Through Sorghum Husk and Unsaturated Polyester Resin.
Abstract: Plastic, a versatile synthetic polymer, holds considerable significance and utility in human society due to its manifold applications. However, its deleterious ecological ramifications have spurred growing apprehensions. This has galvanized the pursuit of ecologically amicable substitutes, propelling interest in the domain of composite materials. Composites are formulated by amalgamating diverse substances, and in this context, Styrene Diluted Unsaturated Polyester Resin (SDUPR) is melded with natural constituents. Among these organic constituents, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 59–65 Read article
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Harnessing Honeybee Venom For Cancer Treatment: A Natural Remedy In Oncology
Abstract: Honeybee venom (HBV) has harvested significant attention as a promising natural compound with therapeutic potential in cancer treatment. This review investigates deeply into the current scientific understanding of honeybee venom, focusing on its anticancer mechanisms, molecular interactions, and potential clinical applications. Honeybee venom comprises various bioactive components, including melittin, apamin, phospholipase A2, and other peptides, which exhibit a wide range of biological activities. Recent research has demonstrated its ability to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 10–14 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Understanding Leukemogenesis: Challenges and Advancements in Diagnostic Approaches
Abstract: Leukaemia development, or leukemogenesis, is a multifactorial process driven by a complex interplay of environmental, genetic, and epigenetic factors. Despite substantial advancements in technology and medicine, which have enhanced our understanding of the contributing factors, early and accurate diagnosis remains a major challenge due to the overlapping clinical features shared by the various leukaemia subtypes. This study explores the molecular and cellular mechanisms underlying leukemogenesis, while also addressing the difficulties …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 11–22 Read article
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Clinical Evaluation of Ayurvedic Intervention (Mahamanjishathadi Kwatha, Kaishora Guggulu, Panchatikta Ghrita, Eranda Taila) in the Management of Ekakushtha W.S.R. to Psoriasis
Abstract: Introduction: Psoriasis is a chronic skin condition causing scaly plaques, typically on extensor surfaces, scalp, and nails, and often leads to quality of life impairments, including physical and mental health challenges. Ayurveda offers a holistic approach targeting root causes and balancing body and mind, while conventional treatments focus on symptom management through therapies that may cause side effects and recurrence. Aim and Objectives: The study aimed to assess the efficacy …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 Read article
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From Rural to Urban: Understanding Taobao Villages to Redress Planetary Urbanisation
Abstract: This study examines Taobao Villages as an innovative model of urbanisation under China’s planetary urbanisation framework. These rural communities, driven by the rise of e-commerce and digital infrastructure, have successfully integrated into the broader urban ecosystem by reconfiguring their historical socio-spatial legacies. Through Lefebvre’s spatial triad framework, the research identifies three key historical legacies that underpin this transformation: (1) Collective Production Practices: Rooted in socialist collectivisation, these legacies include organisational …
Published in International Journal of Urban Design and Development · Vol. 3, Issue 1, 2025 · pp. 1–7 Read article
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Synthesis and Characterization of Sustainable, Low-Cost, Biomass-Derived Carbon Films from Hevea Brasiliensis (Rubber) Wood for Environmentally Friendly Gas Sensors with Enhanced Selectivity and Sensitivity to Polar Vapors and Hazardous Gases
Abstract: Hevea brasiliensis (rubber) wood sawdust was utilized to fabricate carbon gas sensors for detecting 1000 ppm of ethanol, methanol, acetone, carbon dioxide, and ammonia gases. The carbon particles were prepared by phosphoric acid impregnation followed by thermal activation and then fabricated into films on conductive and non-conductive substrates using the doctor blade method. X-ray diffraction (XRD) analysis revealed distinct graphitic features with peaks at the (002) and (100) planes, indicating …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 1, 2025 · pp. 22–36 Read article
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Socio-Economic Impacts of Rivers State Government Ring Road Project on Residents of Port Harcourt Municipality
Abstract: As nations strive towards improving the socio-economic well-being of its citizens, efficient transportation system in the form of ring roads have become a desideratum for reducing traffic congestion and enhancing movement of goods and services. The paper examines the impacts a ring road can have on residents of project area with emphasis on Port Harcourt. The Hazard and Effect Management Process (HEMP) technique developed by SHELL was used to examine …
Published in International Journal of Rural and Regional Development · Vol. 3, Issue 1, 2025 · pp. 42–51 Read article