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314 articles for “Toxicity”
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Using of Rat Model Over Other Species: A Review
Abstract: The first domesticated morphological features to be used in studies were rats. Scientists employed the brown rat Rattus norvegicus to study human biology and therapeutics two decades ago, focusing on the consequences of hunger and oxygen deprivation. Rats have been used to answer a wide range of basic science problems relevant to common human ailments in the fields of pharmacology, immunology, physiology, nutrition, behaviour, learning, and toxicity. The article gives …
Published in International Journal of Animal Biotechnology and Applications Read article
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Competency of Natural Fiber Based Eco-Friendly Friction Lining Composites Over the Conventional Friction Material
Abstract: The Braking system is important system of automobiles and is responsible for providing better performance and safety. A Millions of automobiles are frequently decelerated and stopped at heavy traffic zone. Overall performance of vehicle braking system depends on braking conditions and brake material. All friction based application releases wear products; either gaseous form or particulate matter form and braking system is prime source of non exhaust particulate matter emission. The …
Published in Journal of Polymer & Composites Read article
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Uses of Nanotechnology in Medical Diagnostic Applications
Abstract: Nanoparticle and nanodevice is a boon for mankind to treat and deal with disease and medical diagnosis respectively. Nanotechnology is formed by the unity of chemistry, engineering, biology and medicine restricted to the nanoscale (about 1–100 nanometer (nm)). For example, early detection of malignant tumors and cancer biomarkers, which is impossible using conventional technologies. In here we will discuss nanosized sensors to identify different pathological parameters, foreign antigen and toxic …
Published in Research and Reviews : A Journal of Medical Science and Technology Read article
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An Insight to Diagnosis and Management of Druginduced Hepatotoxicity: An Overview
Abstract: (ADRs) Adverse Drug Reactions are constitute and mutual chief health problem. Throughout the last period liver toxicity has remained one of the most recurrent reasons for pharmacovigilance protection intelligences and the withdrawal from the marketplace of an accepted medicinal product. Liver is a main organ elaborate in the systemic deposition and decontamination of exogenous and endogenous ingredients. Liver disfunction challenges not only health care specialists but also the pharmaceutical manufacturing …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 39–54 Read article
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Effect of Initial Temperature and Diameter of Ethanol Droplet on Evaporation Dynamics in Convective Air Medium
Abstract: Ethanol is a suitable biofuel as it has fewer toxic emissions and higher-octane numbers. For spray combustion applications, the gas phase motion must be considered while numerically investigating the fundamental aspects of droplet evaporation and combustion processes. Hence, we have numerically simulated the evaporation dynamics of an isolated spherically shaped ethanol droplet under a forced convective air environment in the absence of gravity. The momentum transfer between two phases is …
Published in Journal of Polymer & Composites Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Preparing Chitosan Hybrid Nanocomposites by Novel Additives for Wound Healing
Abstract: Biomaterials made from chitosan have been discovered to be particularly unique marine polysaccharides (or polycarbohydrates) with a wide range of physico-chemical and biological characteristics suitable for biomedicine field. Due to net positive charge of chitosan, it is essentially capable of chemically binding with negatively charged surfaces A biodegradable blend of chitosan nanoparticles (CHT), poly vinyl alcohol (PVA) and polyethylene glycol (PEG) hybridized with metal oxides nanopowders were prepared and used …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 9–23 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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Descriptive Study to Assess the Knowledge Concerning Bio-medical Waste Handling Among B.Sc. Nursing Scholars of Selected Nursing Colleges of District Kangra (H.P)
Abstract: The waste generated from health actions can be dangerous, poisonous, toxic and even mortal because of their high probable for ailment transmission and injury that also outcome in environmental disturbances. The first step to safe disposal of dangerous hospital wastes. an acceptable and proper knowledge of Bio Medical Waste Management among the students of Nursing is important. Appropriate managing of health care waste is then a vital part of environmental …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 1, 2023 · pp. 1–7 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Nutraceutics: Opening the Debate for a Framework for the Safety and Efficacy of Nutraceuticals Formulations
Abstract: As of right now, there is no precise definition for nutraceuticals that distinguishes them from other food-based categories such herbal products, dietary supplements, pre- and probiotics, functional foods, and fortified foods. Several studies have shed light on the possible mechanisms of action of pharmaceutically active ingredients in food, emphasizing their ability to improve health, lower the risk of disease, and promote general wellbeing. However, Nutraceuticals confront difficulties in substantiating safety …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 27–33 Read article
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Advances in Solubility Enhancement Strategies for Poorly Water-soluble Drugs: A Comprehensive Review
Abstract: Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 01–09 Read article
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Performance Evaluation of Eco-friendly Cutting Fluid in Machining Process—An Approach towards Environmentally Friendly Production
Abstract: The machining industry's evolving environmental consciousness has prompted a growing demand for cutting fluids devoid of chlorine and sulphur, thus fostering sustainable machining practices. This surge in demand is driven by mounting apprehensions over environmental contamination and worker safety. As the industry transitions to modern cutting fluids, it becomes imperative to comprehend their effectiveness and the optimal machine parameters required for their deployment in the turning process. In our current …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 149–160 Read article
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Exploring Nutool (Irrigation) as A Treatment Method in Ilaj Bit Tad-Beer (Regimenal Therapy)
Abstract: The Unani system of medicine employs four primary modes of treatment: Illaj bil ghiza (dietotherapy), Illaj bil Dawa (pharmacotherapy), Illaj bit tadbeer (Regimenal therapy), and Illaj bil yad (surgery). Illaj bit Tadbeer encompasses a range of regimenal interventions, including Hijamah (cupping), Irsal alaq (leeching), Fasd (venesection), Dalak (massage), Nutool (irrigation), Qay (Emesis), Idrar-i-Bawl (Diuresis), Tariq (Diaphoresis), Munzij and Mu'shil therapy (Concoction and purgation), Bukhoor (medicated steam), kayy (cauterization), Huqna (enema), …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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Unani Medicine Uncovered: Core Concepts And Quality Evaluations
Abstract: Unani medicine, a traditional healing system primarily reliant on herbal remedies, finds its roots in the ancient wisdom of Greek philosopher Hippocrates (460–377 BC) and his associates. Its evolution and prominence, however, owe much to the support of Persian and Arab empires before making its way to the Indian subcontinent around the mid-14th century. Unani practitioners believe that each individual possesses a unique temperament shaped by the interplay of four …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2024 · pp. 10–17 Read article
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Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms
Abstract: Recent advances in pharmaceutical dosage forms revolutionize drug delivery, prioritizing targeted therapy and patient well-being. Enhanced drug carriers address complex medical challenges, from high-grade gliomas to ocular drug delivery, maximizing therapeutic efficacy while minimizing adverse effects. Traditional dosage forms like tablets and capsules undergo meticulous formulation and manufacturing processes, integrating Quality by Design principles for consistent product quality. Liquid formulations encounter stability challenges, necessitating rigorous stability testing and pH monitoring. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 77–89 Read article
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Zinc Oxide Nanoparticles from Murayya koenigii: Antibacterial Potential Review
Abstract: Nanoparticles (NPs) display unique characteristics in contrast to conventional physico-chemical synthesis methods, and they are utilized in various life science fields including surface coating, catalysis, food packaging, corrosion prevention, environmental cleanup, electronics, biomedical applications, and antimicrobial purposes. Metal NPs synthesized through green methods, particularly from plant origins, have garnered significant interest because of their inherent traits such as environmental friendliness, quick production, and cost efficiency. Over the past few years, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 54–67 Read article
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Biological Synthesis of Silver Nanoparticles Using Hibiscus Sabdariffa Leaf Extract and It’s Antibacterial Sensitivity Assay
Abstract: In this study, AgNO3 was effectively used to synthesize silver nanoparticles. Hibiscus sabdariffa leaf extract was used to promptly and easily synthesize silver nanoparticles. An UV-Visible spectrophotometer showed absorbance peak in range of 300-600 nm. The procedure was found to be easy to follow, quick, least step and safe for the environment. It is non-toxic, and a viable substitute for traditional physical or chemical procedures. At room temperature, silver ions …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 08–13 Read article
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Properties and antimicrobial activity of bacterial nanocellulose composite incorporated with silver nanoparticles based on green synthesis
Abstract: Green silver nanoparticles (AgNPs) synthesized using medical plant extracts as capping and reducing agents demonstrate broad applicability in addressing the threat posed by infections. In this study, we present a sustainable, low-toxicity, and cost-effective bacterial nanocellulose composite with silver nanoparticles based on green synthesis that uses Origanum vulgare as a reducing agent due to numerous biological components. The formation of AgNPs in composite and morphological properties was analyzed using scanning …
Published in Journal of Polymer & Composites · Vol. 12, Issue 1, 2024 · pp. 323–328 Read article
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Sustainable Materials and Practices in Residential Interior Design
Abstract: Sustainable materials and practices have emerged as pivotal elements in shaping the ethos of residential interior design. This explores the integration of eco-friendly principles into residential spaces, focusing on materials selection, design strategies, and the broader implications for environmental stewardship. The adoption of sustainable materials encompasses a spectrum of considerations, ranging from renewable resources to recycled materials and low-impact manufacturing processes. This abstract elucidates the significance of materials such as …
Published in International Journal of Solid State Innovations & Research · Vol. 1, Issue 2, 2023 · pp. 21–31 Read article