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843 articles for “Structure-Based”
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Smart Biopolymer–PCM Composite Modules with Embedded Wireless Thermal Sensing for Autonomous Energy Storage Applications
Abstract: The development of multifunctional polymer composite systems for intelligent thermal energy storage has gained significant attention due to the increasing demand for sustainable and autonomous thermal management technologies. In the present study, a wireless-integrated biopolymer–phase change material (PCM) composite module embedded with thermal feedback sensors was successfully fabricated and experimentally investigated for advanced thermal energy storage applications. Polylactic acid (PLA) was employed as the biodegradable polymer matrix, while paraffin wax …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 193–205 Read article
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SYNTHESIS AND CHARACTERIZATION OF Mn2+ DOPED LiPbX3(X = Cl, Br, I)
Abstract: In this paper the structural, electronic and optical properties of Mn doped Pb based cubic perovskites LiPbX3(X= Cl, Br and I) were studied by wet chemical method (sol gel method). For Mn doped LiPbX3(X= Cl, Br and I) NCs, MnCl2 and PbBr2 were added in molar feed ratio 1.35 mole% and nan crystal were examine with the help of TEM and their structure were confirmed by X-ray diffraction (XRD). Additionally, …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 48–54 Read article
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Secure Forge: Deepfake Image Detection Using Vision Transformers
Abstract: Deepfake technologies have become a major risk to the credibility and trustworthiness of digital visual information. Using powerful generative models like GANs and autoencoders, deepfakes can generate highly realistic fake videos and images, resulting in misinformation, identity theft, and public loss of trust in digital media. Classic Convolutional Neural Networks (CNNs) while being highly effective in initial-stage, deepfake detection tend to be limited by their local receptive fields and dependency …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 12, Issue 3, 2025 · pp. 32–45 Read article
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Impact of a Nurse-Led Work-Based Intervention on Job Performance and Job Satisfaction Among Nurses in Selected Hospitals in Erode
Abstract: Job satisfaction is a critical aspect of nurses’ professional lives, influencing patient safety, staff morale, productivity, performance, and overall quality of care. Higher levels of job satisfaction have been linked to improved patient outcomes. This study aimed to assess the level of job satisfaction among staff nurses before and after a nurse-led work-based intervention, evaluate the effectiveness of the intervention, and examine the association between posttest job satisfaction scores and …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 19–27 Read article
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Design Analysis of PALF Natural Fiber Composite Laminate under Tensile Loading Condition using Simulation Approach
Abstract: Plant-based fibre reinforced materials are increasingly being employed for a variety of structural and non-structural purposes. Plant and animal-based fibres have different characteristics depending on a variety of circumstances. Mechanical qualities are primarily determined by parameters such as matrix, fillers, fibre content, fibre treatment, and fabrication techniques. The present work aim in analyzing the PALF natural fiber using simulation approach. In the process laminates are prepared as per ASTM standards …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 2, 2023 · pp. 23–29 Read article
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Ligand Based Drug Virtual Screening in Computer Aided Drug Design: A Review
Abstract: Computer-Aided Drug Design (CADD) has revolutionized the drug discovery process by providing efficient and cost-effective methods for identifying potential drug candidates. Within CADD, ligandbased virtual screening techniques play a pivotal role in the early stages of drug discovery. This review provides a comprehensive overview of ligand-based drug virtual screening, focusing on its principles, applications, challenges, and future directions. Fundamentals of ligand-based virtual screening, including pharmacophore-based methods, similarity searching, and machine …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 1–8 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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Deep Learning Applications in Bone Fracture Detection for Improved Radiographic Diagnostics
Abstract: Bone fracture detection is a critical aspect of medical diagnostics, traditionally relying on manual interpretation of radiographic images by experienced radiologists. This discipline has undergone a revolution with the introduction of machine learning (ML), which can improve accuracy, shorten diagnosis times, and lessen human error. This study investigates the use of different machine learning methods to enhance and automate the identification of bone fractures in radiography pictures. We utilized a …
Published in International Journal of Optical Innovations & Research · Vol. 2, Issue 2, 2024 · pp. 17–22 Read article
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Thermal Performance of Concentrating Solar Panels
Abstract: The study shows a detailed analysis of the thermal performance of concentrating solar panels and the temperature increase due to concentrated solar radiation. This work proposes a configuration to reduce temperature rise, maintain good panel efficiency, and increase output power. The configuration is based on a sandwich structure including a phase change material (PCM), which absorbs the thermal energy excess generated by the concentrated solar radiation onto the PV panel. …
Published in Journal of Thermal Engineering and Applications · Vol. 12, Issue 1, 2025 · pp. 1–10 Read article
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A SEIR-Informed Stacked Fusion of Prophet, XGBoost, and LSTM for Ward-Level Epidemic Forecasting in Amravati Municipal Corporation
Abstract: Municipal epidemic preparedness depends on accurate short-horizon forecasts at fine spatial granularity. Ward-level incidence series are typically nonstationary due to changing contact patterns, interventions, reporting delays, and heterogeneous demographic and environmental factors. This paper presents a mathematically formulated hybrid forecasting architecture designed for Amravati Municipal Corporation (AMC). The method decomposes observed incidence into (i) a mechanistic SEIR baseline that enforces epidemiological structure and (ii) a data-driven residual learned using Prophet …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 13, Issue 1, 2026 · pp. 17–23 Read article
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Mechanical Performance Evaluation of Brachyuran Shell Particle-Infused S-Glass Fibre Epoxy Polymer Composites
Abstract: Epoxy composites bio-filled with brachyuran crab shell powder and reinforced with S-glass fibres at different loadings (2%, 4%, and 6%) are tested for their mechanical properties in this work. Using modest amounts of filler significantly improved hardness, ultimate tensile strength, and flexural strength in the empirical data. The largest increase in hardness was 64.42% at 4% filler, up from 26.22% at 2%; however, there was a dramatic decrease to 13.11% …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 500–507 Read article
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Development of Compact RF Filters for Modern Wireless Communication Systems
Abstract: Modern wireless communication systems such as 5G, 6G, Internet of Things (IoT), satellite communication, radar systems, and smart wireless networks require compact and highly efficient RF filters for reliable signal transmission and interference suppression. RF filters are important components that allow desired frequency signals to pass while rejecting unwanted frequencies and noise. With the rapid growth of wireless devices and limited spectrum resources, the demand for miniaturized, low-loss, multi-band, and …
Published in Journal of Microwave Engineering and Technologies · Vol. 13, Issue 2, 2026 Read article
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Analysis for Pier of Railway Bridge
Abstract: The load-bearing capacity of a pier is determined by the combined effects of the load from the train and the self-weight of the girder it supports. The bending of the pier is influenced by its height, which necessitates a careful assessment of the pier's thickness across various girder spans and pier heights. This evaluation ensures that the pier can withstand the imposed loads while adhering to permissible deflection limits. By …
Published in Trends in Transport Engineering and Applications · Vol. 11, Issue 1, 2024 · pp. 37–43 Read article
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Study to Assess the Effectiveness of Teaching Program on Knowledge Regarding Management of Patients with Regenerative Orthopedics Procedures Among Orthopedic Nurses at Selected Orthopedic Departments
Abstract: Regenerative therapy is an emerging treatment approach in medical science. It focuses on the use of stem cell therapy, biological treatments, tissue engineering, platelet-rich plasma, prolotherapy, and nutraceutical supplements to replace or restore dysfunctional structures or organs. Regenerative therapy emphasizes the body’s natural healing process; it supports physiological healing mechanisms and repairs damaged tissues. It is a minimally invasive approach with expanding applications across various medical fields, including surgery, degenerative …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 7–11 Read article
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Evaluation of Building Foundations: A Structural Engineering Perspective
Abstract: This study focuses on the comprehensive assessment and design of building foundations, emphasizing the critical relationship between structural loads and soil properties. The depth of the foundation is determined by analyzing the load exerted on the column and the soil's bearing capacity, both of which play a pivotal role in ensuring stability. Similarly, the foundation base size is calculated based on these parameters to ensure it effectively transfers the load …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 1, 2025 · pp. 6–18 Read article
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Advances in Polymer-Modified Concrete using XAI
Abstract: Industry 4.0 technologies are being quickly adopted by the construction sector, opening new avenues for enduring operational and environmental issues. This sector looks at how explainable AI can forecast air and enhance the quality of building materials. XAI, AI, ML, and big data drive a new paradigm in polymeric material development. The effective XAI and ML-assisted design creates innovative, high-performance polymeric materials. It covers building a database and representing structures, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 133–144 Read article
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Importance of Thesaurus in Natural Language Processing for Scholarly Data Extraction
Abstract: The exponential growth of scholarly literature needs advanced methods for efficient data extraction and knowledge discovery. Natural Language Processing (NLP) has emerged as a crucial technology in automating the analysis and organization of academic texts. Among various linguistic resources, thesauri serve as important tool for enhancing semantic understanding by providing structured vocabularies, synonyms, and hierarchical relationships between terms. This paper examines the importance of thesauri in enhancing NLP-based scholarly data …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 19–24 Read article
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Safety of Foundation of Building
Abstract: The design of a building's foundation requires careful consideration of the load intensity applied from the structure above. To ensure stability and safety, the foundation depth must be sufficient to support the loads effectively. For residential buildings, where the loads are relatively lower, a foundation base size of 2.5 × 2.5 meters or 3 × 3 meters is typically adequate. In contrast, for structures with significantly higher loads, such as …
Published in Journal of Structural Engineering and Management · Vol. 11, Issue 3, 2024 · pp. 51–60 Read article
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Intersection Safety in Urban Environments: A Review of Risk Factors and Crash Patterns
Abstract: Urban intersections are critical points of interaction between multiple road users, including cars, buses, two-wheelers, cyclists, and pedestrians. As cities continue to expand rapidly, the density and complexity of traffic at intersections increase, making them among the most dangerous segments of the roadway network. Numerous studies show that intersections account for nearly half of all urban road crashes, making them central to safety research and planning. This review paper synthesizes …
Published in Journal of Industrial Safety Engineering · Vol. 13, Issue 1, 2026 · pp. 31–35 Read article