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412 articles for “PKA/CREB pathway”
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Interrelationship Between Psychological Stress and Gastrointestinal Physiology: Role of the Gut–Brain Axis
Abstract: The relationship between stress and gut microbiome is a critical area of medical research underscoring the relativity and impact of psychological and emotional states on gastrointestinal (GI) health. This paper investigates the intricate relationship between stress and digestive health by analysing the influence of stress hormones, gut–brain interactions, and psychosocial determinants. Both acute and long-standing stress responses may disrupt normal gastrointestinal activity, affecting motility, secretion, intestinal microbiota, and overall digestive …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Metamaterial-Based Thermal Shielding Structures for Reusable Hypersonic Space Transportation Systems
Abstract: The rapid development of reusable hypersonic space transportation systems has intensified the need for advanced thermal protection technologies capable of withstanding extreme aerodynamic heating conditions encountered during atmospheric re-entry and sustained hypersonic flight. Conventional thermal shielding materials often suffer from high structural weight, limited adaptability, thermal fatigue, and degradation under repeated thermal cycling. This study proposes a novel Metamaterial-Based Thermal Shielding Structure for Reusable Hypersonic Space Transportation Systems, integrating engineered …
Published in Journal of Aerospace Engineering & Technology · Vol. 16, Issue 2, 2026 Read article
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Crop Metabolism: A Biochemical Perspective on the Synthesis of Key Biomolecules and Structural Adaptations
Abstract: Crop metabolism involves intricate biochemical pathways that govern the biosynthesis of essential biomolecules, ensuring growth, development, and adaptability in various environmental conditions. Key processes include the synthesis of nucleic acids, amino acids, proteins, carbohydrates, organic acids, lipids, and natural products, each playing vital roles in maintaining cellular homeostasis. Nucleic acids drive genetic information storage and transfer, while amino acids and proteins form the backbone of enzymatic and structural cellular functions. …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 1, 2025 · pp. 26–31 Read article
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Communication Interpretation Device for Deaf and Blind
Abstract: At immediate circumstances differently abled people require pathway to lead a normal life. Technology has always helped people with disabilities. Due to digital revolution, many apps and gadgets have reduced the challenges faced on a daily basis by differently abled. The aim of our research paper is to create a single device solution in such a way which is simple, fast, accurate and cost-effective. The main purpose of the prototype …
Published in Journal of Telecommunication, Switching Systems and Networks Read article
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Strategies for Flood Mitigation
Abstract: The world has always experienced change. Water-too much or too little is the most common cause of migration and a city's downfall. The notable and significant distinction right now is that we are seeing it in real-time for the first time in human history. We contributed to the dangers that were produced, and we contributed to the remedies that will influence the pace and scope of change and disruption. We …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 1, 2023 · pp. 1–9 Read article
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Breakup Fusion of 18O with 144Sm
Abstract: Excitation function measurements have been done for the evaporation residues populating in the system 18O+144Sm. For this purpose, the stacked foil activation technique has been used subsequently accompanied by offline γ-ray spectrometry. The analysis of the experimental cross section of three evaporation residues 158Tm(p3n), 157Tm(p4n), and 155Ho(ap2n) has been done in the light of theoretical code PACE-4. Current findings demonstrate that the experimental cross sections of evaporation residues formed via …
Published in Journal of Polymer & Composites · Vol. 11, Issue 7, 2023 · pp. 53–59 Read article
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Design and Development of Ankle Foot Orthosis for Foot Amputated Person by Using Carbon Fibre
Abstract: Ankle and foot orthotics play a pivotal role in the rehabilitation of individuals who have suffered a stroke, aiding in the restoration of their gait and overall mobility. However, optimizing the effectiveness of these orthoses requires a personalized approach that takes into account each patient's unique biomechanical characteristics. This study delves into the innovative use of carbon fiber combined with cost-effective 3-D printing technology to craft custom foot plate orthoses …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 115–121 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Risk & Opportunities in Development of new Drugs: A New Perspective
Abstract: The procedures of drug discovery and development are briefly described in this article. Our goal is to assist researchers whose work may be pertinent to the discovery and/or development of new drugs in framing their research reports in a way that appropriately situates their findings within the drug discovery and development process and supports the efficient translation of preclinical research to humans. One overarching theme of our article is the …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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Exploring the properties and extraction of neem leaves
Abstract: Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 32–39 Read article
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A Conceptual Exploration of Carbohydrate, Protein, and Fat Metabolism within the Realm of 3D Computational Biology
Abstract: Maintaining energy balance within the body is just as crucial as other vital physiological processes. Energy is generated through a myriad of chemical reactions occurring within the cells of all living organisms. This unique characteristic enables living organisms to extract energy from their surroundings and utilize it for essential activities such as growth, development, and reproduction. While it is commonly assumed that individuals with lower body weight have higher metabolic …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 55–62 Read article
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Multifactorial Diseases Becoming the Epigenetic Factor for the Genz
Abstract: This comprehensive paper investigates the complex interplay between multifactorial diseases, particularly obesity and cardiovascular disease (CVD), and their relationship with epigenetic mechanisms, highlighting the transgenerational implications of these interactions. The multifaceted nature of obesity and CVD, involving genetic predisposition, environmental influences, and epigenetic modifications, underscores the intricate pathways contributing to disease susceptibility and progression. Drawing upon a synthesis of diverse research findings, the paper elucidates the critical role of genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 16–22 Read article
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Alopecia Areata: Complex Roots and Potential Cures
Abstract: Autoimmunity is when the healthy organs of an individual’s body are attacked by its own immune system, leading to illness or functional abnormalities. The hair follicles (HFs) are wrongly destroyed by the immune system in a condition known as Alopecia Areata and results in chronic non-cicatricial hair loss discernible by spherical patches. It’s a severely worsening or relapsing malady that can be permanent during severe falling out of hair. In …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 41–54 Read article
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Optimizing Manufacturing Processes with Taguchi Method in Production Engineering
Abstract: The Taguchi Method, pioneered by Genichi Taguchi, stands as a powerful optimization tool within the realm of production engineering. This paper delves into the principles, applications, and significance of the Taguchi Method in enhancing manufacturing processes. With a focus on minimizing variation and improving performance, this methodology plays a crucial role in addressing challenges faced by industries in their pursuit of operational excellence. The core components of the Taguchi Method, …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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The Role of DevOps in Financial Network Security
Abstract: This study provides a comprehensive analysis of the significance of Development and Operations (DevOps) in ensuring the security of financial networks. With an ever-increasing need for speed, efficiency, and quality in the Fintech sector, integrating DevOps methodologies into operational workflow has become critical. Adopting DevOps practices not only expedites the software delivery cycle, but also ensures comprehensive security. The study explores the adoption of Secure DevOps strategies, the importance of …
Published in Recent Trends in Programming languages · Vol. 11, Issue 1, 2024 · pp. 21–28 Read article
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Organometallic Osmium Compounds in Cancer Therapy
Abstract: The exploration of organometallic complexes with osmium as potential anticancer agents was indeed an area of ongoing research. These complexes were being investigated for their unique properties and mechanisms of action against cancer cells. However, it’s essential to note that the field of scientific research is dynamic, and new findings may have emerged since then. Organometallic complexes with osmium can be designed to exhibit specific features that make them promising …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 2, 2023 · pp. 01–25 Read article
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Agro- waste to Bioenergy Production in India
Abstract: The transition towards sustainable energy sources is imperative for mitigating environmental degradation and addressing energy security concerns. In the context of India, where biomass constitutes a significant portion of renewable energy potential, understanding its availability and utilization is paramount. The Biomass Resource Atlas of India serves as a comprehensive tool for assessing biomass resources, offering insights into regional and seasonal availability. However, despite substantial biomass generation, its utilization for power …
Published in Research & Reviews : Journal of Ecology · Vol. 13, Issue 1, 2024 · pp. 27–40 Read article
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Inhibition of Quorum Sensing to Mitigate the Risks of Membrane Biofouling in Biological Wastewater Treatment
Abstract: Membrane-based systems play a pivotal role in various applications, providing efficient separation, purification, and filtration processes across diverse industries such as water purification and desalination. However, this system faces major challenge of membrane biofouling impacting the efficiency and sustainability of such systems. Biofouling occurs when various microorganisms like bacteria, fungi, etc. adheres to the surface of membrane and form biofilm which results in reducing membrane permeability and increasing its operational …
Published in Research & Reviews : Journal of Ecology · Vol. 13, Issue 1, 2024 · pp. 18–26 Read article
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Biomass Resource Assessment & Management of Amritsar District of Punjab: A Case Study
Abstract: The biomass resource assessment and management of Amritsar district in Punjab highlights the intricate balance between biomass generation and consumption, with significant implications for various sectors including dairy farming. Through meticulous evaluation of agricultural residue, animal waste, and forestry biomass, the study unveils the potential for bioenergy production within the region. Key findings indicate a substantial surplus of biomass, primarily derived from agricultural activities, alongside seasonal variations in availability. For …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 1, 2024 · pp. 28–38 Read article