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161 articles for “In silico”
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Functionally Graded Natural Fibre and SiC-reinforced Polymer Composite: Mechanical Properties
Abstract: Multifunctional materials, also called functionally graded materials (FGMs), are based on natural fibres or fillers and vary in composition and/or microstructure to control functional, structural, or thermal, properties. Functionally graded materials (FGMs) have been created for use in spacecraft, aircraft, and other engineering applications because they can withstand extremely high temperatures. Particle-reinforced FGMs, which make up the majority of FGMs, are made differently depending on their position. The mechanical and …
Published in Journal of Polymer & Composites · Vol. 11, Issue 4, 2023 · pp. 1–14 Read article
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Design and Implementation of Low Power and Area Efficient Sub Threshold Level Shifter Using 16 nm CMOS Technology
Abstract: An efficient method of modifying subthreshold voltages is proposed here. As an alternative to static power dissipation, the suggested design allows for charging of internal nodes through VDDH. The force of the pull-down mechanism may be increased by connecting a second auxiliary circuit. The transition energy for input frequencies between 1 and 5 MHz is 84 fJ, the propagation delay is 46 ns, the dynamic power dissipation is 0.3 mW, …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 1, 2023 · pp. 16–24 Read article
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Drugs for Alzheimer’s Disease from Salix Alba Discovered Computationally Utilizing Virtual Screening and Docking against 1b41 Protein
Abstract: Objective : The of this research is to evaluate the feasibility of using molecular docking techniques to identify novel acetylcholinesterase, a key enzyme implicated in the pathogenesis of Alzheimer’s disease, a neurodegenerative disorder with a gradual but steady progression to death, due to the gradual accumulation of beta-plaques and neurofibrillary tangles, as well as a decline in acetylcholine levels. Due to its function in converting acetylcholine into acyl and choline …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 07–19 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Performance Analysis of a Three-DOF Piezoelectric Vibration Energy Harvester
Abstract: Mechanical vibration energy can be transformed into electrical energy by a vibration energy harvester, which can then be stored in the battery for later use. It can convert vibrational motions like walking, leaping, running, etc. into pure renewable energy. This can turn previously squandered energy into energy that can be used to recharge wireless sensors and portable electronics. If these gadgets are used widely, they can produce a lot of …
Published in Journal of Polymer & Composites · Vol. 11, Issue 9, 2023 · pp. 10–18 Read article
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Valeton Phytoconstituents from Curcuma Phaeocaulis as Prion Protein Mutant V210I Inhibitors: A Computational Docking and Virtual Screening Study
Abstract: Objective: Creutzfeldt-Jakob disease (CJD), a neurological disorder that is sporadic, fatal, communicable, and worsens rapidly, is caused by abnormal folding of prion proteins. Identifying and assessing the potential of phytocompounds from the Curcuma phaeocaulis Valeton plant as a new therapeutic candidate aimed at the treatment of CJD is the objective of this research article. Methods: In this experiment, we assessed outcomes following an in-silico assessment to design a new oral …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 1–16 Read article
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Modeling of the Mechanism of Generating Processes of Water Electrolysis and Photosynthesis with Solar Energy Used for Productions of Gas Oxygen and Hydrogen, of Concentrate of the High-calorie Microalgae Chlorella, and for Industrial Wastewater Treatment
Abstract: The use of solar energy for generation of the process of water electrolysis, permitting the oxygen and hydrogen gases production, concentration of the high-calorie fast productive Chlorella microalgae, and industrial wastewater treatment is the most promising direction today. This is explained by the complete absence of electrical energy consumption for the implementation of these industrial technological projects. No less interesting is the process of photosynthesis of phytoplankton cells, which also …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 7–21 Read article
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Nanowire Photodetectors and Applications: A Review Study
Abstract: The utilization of nanowires and nanowire structures as photodetectors is an arising research subject. Novel gadget structures incorporated in single nanowire gadgets are additionally being effectively contemplated and created. Here, general NW-PD ideas are investigated, along with a point-by-point depiction of the actual phenomenon happening in nanowire photoconductors & phototransistors. Low dimensional frameworks like nanotubes and nanowires have intriguing, and technologically valuable, optical and electrical properties. Studies on these frameworks …
Published in Journal of Semiconductor Devices and Circuits · Vol. 10, Issue 2, 2024 · pp. 15–19 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Experimental Investigations on Aluminium Composites Materials Using Stir Casting Process
Abstract: In physical operations, accoutrements in motorcars and aeronautical machine factors, aluminium and its alloys are extensively used. In this study an effort is made to ameliorate the properties of aluminium essence matrix compound (A356) for manufacturing of machine rudiments taking High Tensile strength, Hardness, Wear resistance and low coefficient of friction, aluminium alloy (A356) reinforced with aluminium oxide, graphite and silicon carbide. In the current work, A356 as base metal …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 302–323 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
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Integration of Nanotechnology in Electric Vehical Technology: A Comprehensive Review
Abstract: The integration of nanotechnology in electric vehicles (EVs) heralds significant advancements in energy storage, efficiency, and overall vehicle performance. This paper explores the current state and future potential of nanotechnology applications in EVs, focusing on battery technology, lightweight materials, and energy conversion systems. In battery technology, nanostructured anodes and cathodes, such as silicon nanowires and lithium iron phosphate nanoparticles, enhance energy density and charging rates. Solid-state electrolytes with nanocomposite materials …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 1, 2024 · pp. 29–34 Read article
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Phase Transformation of Manganese Steel: A Role of Alloying Elements
Abstract: Low alloyed steels that are both strong and ductile are the primary focus of new material concept work due to economic considerations. One key to making good use of these materials is applying the right heat and thermo mechanical treatments. Phase transitions can be influenced by using different alloying procedures. Microstructural evolution and mechanical characteristics were investigated in relation to varying manganese, silicon, and chromium levels. Developing high-strength flat rolled …
Published in Trends in Mechanical Engineering & Technology · Vol. 14, Issue 2, 2024 · pp. 15–20 Read article
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Multitarget Molecular Docking Using Curcuma longa Phytocompounds for Polycystic Ovary Syndrome Treatment
Abstract: Objective: The primary goal of this research is to understand and describe specific aspects of molecular interaction, it includes studying various aspects such as binding affinity, binding mode, and stability of the ligand-protein complex. Molecular docking is a computational technique used to predict the preferred orientation of one molecule to a second when bound together to form a stable complex. In this study, molecular docking will be employed to stimulate …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 15–28 Read article
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Nanotechnology in Context of Environment and Industrial Development: A Review
Abstract: Climate change and sustainable development with context to environment has been one of the main concerns and challenges of 21st century. Industrialization and development go hand in hand, so we need to devise green synthetic routes so that our environment stays protected. In the past two decades, there has been significant advancement in the field of nanotechnology. Many cost-effective methods have been devised for large-scale production. Significant improvements have been …
Published in Journal of Industrial Safety Engineering · Vol. 11, Issue 2, 2024 · pp. 7–14 Read article
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Molecular Docking of Saraca asoca (Ashoka) Phytocompounds for Ovarian Cancer Therapy
Abstract: Objective: One of the top five cancers that causes death in women is ovarian cancer, with increases awareness till date the rate of survival is unpredictable. Even though there are advance treatments introduced, chemotherapy is most suggested to the ovarian cancer patients but the rate of relapses increased and the tumors get resistant towards the drugs. This present study is to evaluate the interaction of phytocompounds from Saraca asoca an …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 27–35 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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Fabrication and Experimental Investigation on Mechanical Properties of Quartz Particulate Reinforced Aluminium Composite
Abstract: Composites are processed by adding a reinforcement phase in a base metal. The base material is known as a matrix and the constituent that is added is called reinforcement. The matrix acts as a support while the reinforcements attach themselves in their respective positions which results in the synthesis of a material which has different mechanical and thermal properties compared to their raw materials. Since aluminium is used as a …
Published in Journal of Production Research & Management · Vol. 14, Issue 3, 2024 Read article
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Optical Along with Magnetic Properties of Doped Nano-Structured Mos2 Nano-Films by Spin Coating
Abstract: The supernatant containing 2D nano-flakes of Molybdenum di-sulphide (MoS2) are synthesized and collected using wet chemical synthesis process. The dispersed MoS2 nano-flakes solution is having strong absorbance values at 627 nm and 690 nm conforming to an energy band gap BG of 1.79 eV and 1.98 eV. Thereafter, MoS2 thin films with and without magnetic doping (cobalt) are deposited on n type silicon by spin coating technique. These samples are …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 297–302 Read article