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108 articles for “Gene prediction”
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Exploring Antimalarial Activity of Chalcone Derivatives through QSAR
Abstract: Background: The core structure of chalcones contains a reactive α,β-unsaturated system within the aromatic rings, which plays a key role in mediating various biological effects. These effects include enzyme inhibition, anticancer activity, anti-inflammatory properties, as well as antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial actions.Modifying the structure by introducing substituent groups to the aromatic ring can enhance potency, reduce toxicity, and expand their range of pharmacological actions. Methods: A total of …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article
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Simulation and Experimental Analysis of Heat Treatment for Steel Tie Rods: A Review
Abstract: The study is related to the actual heat treatment and simulation of the physical deformation of the steel tie rod and compares the observations for process optimization. The general methodology is to go for either traditional or induction hardening after getting the chemical composition of the material, followed by tempering, which is a key technique for improving the mechanical properties of materials, strength, hardness, etc., and to release stresses. This …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 1, 2025 · pp. 43–51 Read article
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An Overview on AI-Driven IoT Based Decision Making in Climate change Study: KSK approach in Climate Change Study
Abstract: As the Earth’s climate enters a state of unprecedented volatility, the traditional methods of ecological observation—characterized by delayed reporting and fragmented data—are no longer sufficient. This study investigates the paradigm shift toward AI-driven IoT (KSK Approach)-based decision-making frameworks as the primary frontier in climate science. By deploying a "planetary nervous system" of interconnected sensors—measuring everything from soil moisture in the Sahel to glacial melt rates in the Arctic—we generate a …
Published in International Journal of Climate Conditions · Vol. 3, Issue 1, 2026 · pp. 1–10 Read article
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The Rise of Fractional Calculus: Novel Applications in Engineering and Biological Systems
Abstract: Fractional calculus (FC) is an advanced mathematical framework that generalizes the classical concepts of differentiation and integration to non-integer, or fractional, orders. This extension of traditional calculus allows for the modeling of complex dynamic systems that exhibit behavior not easily captured by integer-order differential equations. Over the last few decades, fractional calculus has seen a rapid rise in popularity, particularly in applied mathematics, engineering, and biological sciences, due to its …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 7–11 Read article
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Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
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Atmospheric Boundary Layer Processes: Impacts on Weather Patterns and Climate Change
Abstract: The atmospheric boundary layer (ABL) is a vital component of the Earth's climate system, acting as the interface between the terrestrial surface and the overlying atmosphere. This layer, typically extending from the surface to a height of a few hundred meters, is characterized by strong gradients in meteorological variables such as temperature, humidity, wind speed, and atmospheric pressure. Understanding the dynamics of the ABL is essential for comprehending weather phenomena, …
Published in International Journal of Atmosphere · Vol. 1, Issue 2, 2024 · pp. 22–25 Read article