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256 articles for “screening”
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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Stilbenes: A Molecular Docking and ADMET Analysis Approach on an Emerging Resource for Scavenging Reactive Oxygen Species in the Field of Colon Malignancy
Abstract: Objective: Colon malignancy, also referred to as colon cancer, originates as precancerous polyps in the colon or rectum, which have the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 29–38 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Computational Biomodeling: Transforming Drug Design with Advanced Simulations
Abstract: Computational biomodeling has emerged as a transformative approach in the field of drug discovery, significantly enhancing the efficiency and precision of identifying and optimizing potential drug candidates. This article explores the various computational techniques utilized in drug design, including molecular docking, molecular dynamics (MD) simulations, free energy calculations, and virtual screening, and examines how these methods collectively contribute to the drug development process. The integration of these advanced simulations allows …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 24–29 Read article
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Multi-Target Molecular Docking of Anantmul (Hemidesmus indicus) Compounds for Tay-Sachs Disease Treatment
Abstract: This research aimed to study the effects of the plant Anantmul (Hemidesmus indicus) in the treatment of Tay-Sachs disease using molecular docking studies. Tay-Sachs disease is a neurodegenerative autosomal recessive disorder caused due to accumulation of the molecule GM2 ganglioside which is caused due to lack of enzyme Beta Hexosaminidase which breaks down GM2 Ganglioside. Anantmul (Hemidesmus indicus) is a an ayurvedic plant used in the Indian subcontinent that has …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 61–69 Read article
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A Literature Review on Extrusion/Spheronisation-A Pelletization Technology
Abstract: Extrusion-spheronization is a leading pelletization technology, widely favored for its economic and commercial viability. It is a cost-effective method suitable for large-scale production, making it the most efficient approach for oral drug delivery. This process provides multiple benefits, such as improved flow characteristics, lower friability, a narrow particle size range, easier coating, consistent packing, reduced likelihood of dose dumping, and more predictable gastric emptying. Pellets usually measure between 0.5 and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 61–71 Read article
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Breast Cancer and Enhancement through Multimedia Instruction
Abstract: The health belief model served as the foundation for the study to determine the factors that most affect women's decisions to receive a breast cancer screening that examined how study participants changed after receiving a multimedia health education intervention. After that, we could create a plan to advance women's rights for the upcoming breast cancer mammograms. Following the multimedia health education intervention, the experimental group demonstrated significantly higher scores in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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IoT in Water Resource Management: Trends and Innovations in Water Level Monitoring Systems
Abstract: One of the major problems faced by most of the countries in the world is the issue of water scarcity, and wastage during transmission has been identified as a major culprit; this is one of the motivations for this research, to deploy computing technician creating a barrier to wastage in order to not only provide more financial gains and help the environment as well as the water cycle which in …
Published in Journal of Microcontroller Engineering and Applications · Vol. 12, Issue 1, 2025 · pp. 39–45 Read article
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Enhanced Biodiesel Production Via Encapsulation of Yeast Cells in Biocompatible Polymers
Abstract: Yeast-based biodiesel production offers a sustainable alternative to conventional fossil fuels. However, factors like harsh environmental conditions and shear stress during processing can limit yeast cell viability and overall biodiesel yield. This study explores the potential of encapsulation technology using biocompatible polymers to improve yeast performance in biodiesel production. Encapsulation can create a protective barrier for yeast cells, shielding them from harsh environments and shear stress during processing. This protection …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 57–62 Read article
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AI-based Drug Discovery-Revolutionizing Pharmaceutical Research
Abstract: The traditional drug discovery process is often costly, time-consuming, and prone to high failure rates. The advent of Artificial Intelligence (AI) has revolutionized this field by significantly enhancing efficiency, reducing costs, and improving success rates. AI-driven approaches, including machine learning (ML), deep learning (DL), and natural language processing (NLP), have transformed key areas such as drug target identification, molecular screening, lead optimization, and clinical trial design. AI models can analyze …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 30–44 Read article
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Cervical Cancer: Understanding Its Causes, Risk Factors, and Preventive Measures
Abstract: Cervical cancer is a form of cancer that begins in the cervix, the lower portion of the uterus, due to abnormal cell growth that can spread or invade other areas of the body. In its early stages, cervical cancer usually shows no obvious symptoms, which is why regular screenings are essential for detecting it early. As the cancer advances, symptoms such as pelvic pain, unusual vaginal bleeding, and pain during …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 26–30 Read article
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MBSR for Better Health: A Narrative Review
Abstract: Introduction: MBSR is a mindfulness-based intervention created by John Kibbat Zinn in the 1970's using the principles of the Buddhist tradition. Since its creation it has found to be effective in various physiological and psychological issues such as cardiovascular diseases, diabetes, blood pressure, hypertension, anxiety, depression, and other ailments. In this particular narrative review, we screened and selected various studies that observed better physiological and psychological health post the MBSR …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 89–98 Read article
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IoT-Enabled Flexible Polymer Sensors for On-Body Health Monitoring and Real-Time Data Transmission
Abstract: Wearable health monitoring systems have grown increasingly vital in shifting care beyond clinical settings, yet many existing technologies remain hamstrung by rigid substrates and unreliable data streaming, impeding continuous and comfortable physiological assessment. Despite advances in flexible materials, most current sensor platforms suffer from limited mechanical endurance, signal instability under dynamic conditions, or an inability to sustain real-time wireless transmission. This work addresses those deficiencies by introducing a fully integrated, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 188–200 Read article
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Effectiveness of Public Health Campaigns in Reducing Oral Cancer Incidence in Urban Maharashtra
Abstract: Introduction: Oral cancer is a major public health problem in urban Maharashtra which can be attributed to high consumption of tobacco, late presentation, and poor awareness. To tackle these issues, public health campaigns have been established to encourage early diagnosis, lifestyle modification, and availability of health resources. This study assesses the impact of these campaigns on the reduction of oral cancer incidence and awareness level in the population. Methods: This …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 1–8 Read article
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A Review of Literature on Breast Cancer: Molecular Insights, Clinical Approaches, and Future Perspectives
Abstract: Breast cancer is the leading cause of morbidity and mortality in women globally. Although both men and women can get the condition, women are more likely to get it, and its prevalence has been rising globally in recent years. The epidemiology, risk factors, pathophysiology, diagnosis, treatment options, and survival rates of breast cancer are all examined in this review of recent research. Breast cancer can show up as a lump …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 15–20 Read article
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Identification and Characterization of Genetic Predictors of Sickle Cell Anemia in Bilaspur District, Chhattisgarh, India
Abstract: In the present decades, sickle cell anemia (SCA) is a challenging task for control of hereditary syndrome in Bilaspur district of Chhattisgarh state, India. The present study aims to identify and characterize genetic predictors of SCA from Bilaspur district (CG) in 2024. A total of 3000+ individuals were screened and categorized into carriers, positive (screening), and diseased cases. Fetal hemoglobin (HbF) level is determined by several genetic factors including genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article
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Zeolite-Y Encapsulated Copper (II) and Cobalt (II) Species as Hybrid Nano-catalysts: Structural and Catalytic Aspects
Abstract: Special properties inherent to zeolites in facilitating the construction of novel upramolecular assemblies by encapsulation of guest molecules (metal complexes) into their large cages can be utilized to use these assembled materials as novel catalysts. These modified solids have the advantages of both behaving as the homogeneous and the heterogeneous catalytic system. In the present work, copper (II) and cobalt (II) complexes of 2-amino ethanoic acid (2-AEA) encapsulated in the …
Published in Journal of Catalyst & Catalysis Read article
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Design and Fabrication of Multi-operation Vegetable Cutting & Slicing Machine
Abstract: The purpose of this gadget is to reduce human effort and make the task of cutting and slicing vegetables considerably easier and faster. Its key characteristics are that it is totally automated, portable, uses less power, and has replaceable stainless, sharp blades. The machine consist of a reciprocating piston arrangement which works is chopping the vegetable and on other hand we constructed a rotating slicer for slicing purpose. A disciplined …
Published in Trends in Machine design Read article
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article