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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Effect of machining parameters on the tool wear in drilling of 3D PF C/C composite
Abstract: Carbon–carbon (C/C) composites are broadly used in aerospace, defence, shipbuilding, chemical, and nuclear industries owing to their high strength-to-weight and stiffness-to-weight ratios. However, they are brittle, anisotropic and non-homogeneous in nature, making them difficult to machine. Incorrect machining parameters can cause defects such as burrs, delamination, and fibre bundles pullout. This paper aims to study the hole surface and tool wear during drilling of 3D pierced fabric (PF) carbon-carbon (C/C) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 269–281 Read article
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Wave plate; what is the angle of its central curved segment which provides biomechanically optimal stability for femoral shaft fracture?:A 3-D Finite Analysis
Abstract: Even though intramedullary nailing of femoral shaft fracture is the standard surgical treatment as it is in tibial fracture, plate fixation might be a choice when the fracture involves open growth plate, patients are of shorter stature or have narrow canals. In these cases, fixation techniques with plate and screws, for example, percutaneous procedures involving wave plate, are useful thanks to minimal invasion and preservation of biological environment surrounding the …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 31–43 Read article
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Investigating the Combined Effect of FDM 3D Printing Parameters on Tensile Behavior of ABS Plastic Using Taguchi Method.
Abstract: Fused Deposition Modelling (FDM) is a commonly utilized method in additive manufacturing. FDM is greatly affected by its printing parameters, which is why selecting the proper parameters is crucial for obtaining the desired properties of 3D printed parts. In this paper we have experimentally and statistically studied the influence of FDM 3D printing parameters (infill pattern, infill density and layer thickness) on tensile strength using Acrylonitrile Butadiene Styrene (ABS) filament. …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 161–169 Read article
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Eco-Friendly Innovations: A Review of 3D Printing with Biodegradable Filaments.
Abstract: This comprehensive review paper delves into the evolving landscape of sustainable additive manufacturing, focusing on the utilization of biodegradable filaments in 3D printing technology. As industries increasingly prioritize sustainability, the adoption of eco-friendly practices like biodegradable materials becomes imperative. The study explores the composition and properties of biodegradable filaments, highlighting their transformation from traditional plastic fibres and the environmental benefits they offer. With a particular emphasis on fused deposition modeling …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 86–102 Read article
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Experimental Study of Roughness Analysis of AISI 316L Material using Fiber and CO2 LBM
Abstract: Laser beam machines have gained significant attention as a precise and versatile method for cutting and shaping materials in various industries. This study investigates the surface roughness characteristics of SS 316L, a commonly used stainless steel, when subjected to laser beam machining using both fiber and CO2 laser sources. The aim of this research is to compare the effects of these two laser types on the final surface finish of …
Published in International Journal of Solid State Innovations & Research · Vol. 2, Issue 2, 2024 · pp. 12–21 Read article
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Synthesis of Magnetically Recoverable Nickel (II) Complex-Functionalized Fe 3 O 4 @ISNA (ISNA= Isonicotinic acid) Nanomaterials: Catalytic Studies on Nitrophenol Reduction and TD- DFT Studies
Abstract: In this study, we aimed to develop a novel, environmentally sustainable, and magnetically separable heterogeneous nanocatalyst, denoted as Fe 3 O 4 @ISNA@NiL (where L represents the ligand). The synthesis involved a two-step process, first, isonicotinic acid was chemically grafted onto the surface of iron oxide nanoparticles (Fe 3 O 4 ) to introduce functional groups capable of further chemical modification. Subsequently, a nickel(II) Schiff base monomeric complex was anchored …
Published in Journal of Polymer & Composites Read article
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Extraction of Impacted Lower 3rd Molars immediately after the Single Visit Endodontic treatment of 2nd Molar - A Case Series
Abstract: Patients who visit a dental clinic often anticipate fewer appointments and quicker recovery times. This expectation is particularly relevant when discussing impacted lower third molars in conjunction with decayed second molars. Dentists often struggle with the decision of whether to start endodontic treatment on the second molar or to proceed with extracting the third molar. This dilemma arises due to the absence of sufficient research or documentation specifically addressing the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 2, 2025 · pp. 6–11 Read article
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Role of Nasya in Pakshaghata: An Evidence-Based Review Study on Its Anatomical Pathway and Therapeutic Action
Abstract: Introduction: Intranasal administration (Nasya), a time-honoured Ayurvedic procedure, offers a unique advantage in treating pathology of neurological and systemic diseases due to its targeted and non-invasive nature. Pakshaghata, a neurological disorder characterized by hemiplegia in ancient Ayurvedic literature, where it is classified as a Vatavyadhi. Methods: By going through all the available literatures and information, this review study explores the concept of Nasya in the context of Pakshaghata management, investigating …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 2, 2025 · pp. 1–8 Read article
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Investigation on mechanical performance of 3D printed PLA-Kraft Lignin composites
Abstract: Bio-based polymer composites are becoming more popular due to the growing need for sustainable and biodegradable materials in additive manufacturing. PLA-kraft lignin composites were created and their mechanical performance in fused deposition modeling (FDM) applications was assessed in this work. Polylactic acid (PLA) was mixed with Kraft lignin, a sustainable by-product of the paper industry, at weight percentages of 0%, 1%, 3%, 5%, and 7%. Melt blending was utilized to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1002–1015 Read article
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Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one: Synthesis and Reactions
Abstract: The presence of the five-member pyrazole nucleus in different structures leads to a large diversity in its applications. In almost every research study, the pyrazole derivatives biological importance faces a competitive challenge in areas of technology, medicine and agriculture. This reflects the description of these derivatives as antibacterial, antifungal, anticancer, antidepressant, anti-inflammatory, anti-tuberculosis, antioxidant as well as antiviral agents. In our review, we will discuss and show the highlights of …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 Read article
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Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Framework-Based Optimization of Catalysis Efficiency through Reaction Pathway Engineering
Abstract: The rational design of heterogeneous catalysts through framework-based approaches has emerged as a transformative strategy for controlling reaction pathways and enhancing catalytic efficiency. This paper examines recent advances in the optimization of catalytic performance through engineered frameworks, including metal-organic frameworks (MOFs), zeolites, and related porous materials. By integrating computational methods with experimental validation, researchers have achieved unprecedented control overactive site architecture, reactant confinement, and elementary reaction steps. This work reviews …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 2, 2026 · pp. 88–99 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Effect of Nebulization With 3% Hypertonic Saline for Airway Clearance on Mechanically Ventilated Patients Admitted in ICUs of Pt. B.D. Sharma, PGIMS, Rohtak
Abstract: Background of the Study: The ability to breathe artificially prolongs life in many situations. Patients requiring mechanical breathing in the intensive care unit are more likely to have complications and even death due to a variety of interconnected causes. As a result, it became critical to rapidly ventilate in the safest and most efficient manner available. Intubated patients have benefited from nebulized suctioning, as it improves lung clearance and decreases …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 20–27 Read article
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Predictive Modeling and Optimization of Tensile and Flexural Strength in FDM 3D Printing Using Decision Trees and Bayesian Optimization.
Abstract: This research investigates predictive modelling and optimization technique for the tensile and flexural strength of PlA (Poly Lactic Acid) in Fused Deposition Modelling (FDM) 3D printing. Employing Decision Trees and Bayesian Optimization enhances comprehension and control of 3D printing process. Precise model predicts PLA material properties based on input parameters. Methodology involves rigorous data preprocessing, encompassing, cleaning, transformation, and normalization. Hyperparameter optimization via grid search systematically explores configurations, optimizing model …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 203–214 Read article
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Influence of Agitation and Static Cultivation on Physicochemical Characteristics of Bacterial Cellulose Produced by Gluconacetobacter liquefaciens MTCC 3135
Abstract: Bacterial cellulose (BC) a with applications spanning biomedical, food, paper, electronics, and diverse industrial processes. Its unique properties include high purity, biocompatibility, and flexibility. BC is a versatile natural biopolymeric material, secreted by certain acetic acid bacteria. BC has numerous benefits over plant cellulose due to distinctive features, e.g., higher polymerization degree and purity, superior crystalline structure, water retention, biocompatibility, and biodegradability, which make BC a valuable material in creating …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 1–11 Read article
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A comprehensive review on Sustainable Pathways to Synthesize 2, 5-Furandicarboxylic Acid (FDCA) from 5-Hydroxymethylfurfural (HMF) via Oxidative Processes
Abstract: The increasing global concern over the environmental impact of traditional plastics derived from petroleum and natural gas has spurred a search for more sustainable alternatives. Bioplastics, which are derived from renewable sources and may be biodegradable, have garnered significant interest as eco-friendly materials. Among the promising building blocks for bioplastics, 2,5-Furandicarboxylic Acid (FDCA) has emerged due to its potential to enhance polymer properties. One key precursor for bioplastics, 5-Hydroxymethylfurfural (5-HMF), …
Published in Emerging Trends in Chemical Engineering · Vol. 11, Issue 2, 2024 · pp. 01–13 Read article