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92 articles for “metabolic enzymes”
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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Turmeric Extract and Curcumin Enhance the Yield of T2 Bacteriophage in E. coli
Abstract: Normal 0 false false false EN-US X-NONE X-NONE It has been demonstrated that turmeric and curcumin—a chemical present in turmeric—have antibacterial and antiviral activity for viruses of humans. Increasing concentrations of turmeric extract and purified curcumin have no effect on the replication of Escherichia coli cultured in Luria-Bertani broth. Increasing concentrations of curcumin enhance the replication of T2 bacteriophage in E. coli cells. E. coli cells treated with purified curcumin …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 3, 2016 · pp. 19–26 Read article
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Inhibition of Replication of Adenovirus by 6-diazo-5-oxo-L-norleucine (DON)
Abstract: Normal 0 false false false EN-US X-NONE X-NONE The antibiotic known as 6-diazo-5-oxo-L-norleucine (DON) inhibits the growth of several types of Gram-positive and Gram-negative bacteria. DON has also been demonstrated to inhibit the replication of poliovirus, respiratory syncytial virus, mumps, and herpes simplex virus in cultured eukaryotic cells. DON is an analogue of glutamine and inhibits the synthesis of glycoproteins and purine nucleotides in cells that are treated with the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 3, 2016 · pp. 31–37 Read article
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Revolutionizing Diabetes Management: Nanostructured Biosensors for Real-time Monitoring
Abstract: Chronic metabolic disease known as diabetes mellitus, which is characterized by dysregulated blood glucose levels, is becoming a major global health concern. The implementation of automated insulin administration systems and continuous glucose monitoring (CGM) has shown promise in the management of diabetes. Nanostructured biosensors, leveraging the unique properties of nanomaterials, offer enhanced sensitivity, selectivity, and biocompatibility, making them ideal candidates for real-time monitoring and personalized treatment. This article delves into …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 1, 2024 · pp. 49–70 Read article
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Exocrine Pancreatic Insufficiency: A Review
Abstract: “Exocrine pancreatic insufficiency”, often known as EPI, is a condition diagnosed in gastroenterology that is defined by insufficient or inaccurate pancreatic fluid secretion as well as pancreatic lipase function. The clinical symptoms as well as metabolic variations that EPI might cause can sometimes lead to outcomes that put a person's life in jeopardy. EPI is common in a variety of conditions that are not related to the pancreas, in addition …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 2, 2024 · pp. 30–34 Read article
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Bioremediation Strategies to Address the Menace of Oil Spills
Abstract: Bioremediation is an innovative and effective process that leverages the capabilities of microorganisms to address and mitigate contamination in both soil and water environments. This technique is particularly valuable in the context of surface oil spills, where it presents significant advantages over traditional physical and chemical remediation methods. Unlike physical methods, which often involve the use of barriers and skimmers to remove oil from the surface, or chemical methods, which …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 43–56 Read article
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Carbohydrate Profile of Root-knot Nematode, Meloidogyne Incognita Infecting Leguminous Plants: A Review
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Carbohydrates are the most abundant class of organic compounds found in living organisms. They originate as products of photosynthesis, an endothermic reductive condensation of carbon dioxide requiring light energy and the pigment chlorophyll. The carbohydrates are the major source of metabolic energy, both for plants and the animals and the later depend on plants for their food. The estimation of carbohydrates …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 3, Issue 3, 2013 · pp. 1–9 Read article
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Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
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In vitro Antioxidant Activity and Phytochemical Analysis of Different Polar Solvent Extracts Obtained from Zanthoxylum rhetsa (Roxb) Bark
Abstract: This study was carried out to evaluate the phytochemical and antioxidant effectiveness of methanolic extract and different fractions (n-butanol, ethyl acetate, chloroform and n-hexane) of Z. rhetsa bark. Phytochemical activity of Zanthoxhylum rhetsa (Roxb) bark extract alkaloids, flavonoids, tannins, steroids, saponins and antraquinones was carried out. Antioxidant scavenging enzyme profile assays were done and profiles were developed for validation. The results indicated that bark extract and fractions of Z. rhetsa …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 5, Issue 3, 2015 · pp. 1–7 Read article