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231 articles for “mechanical integrity”
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REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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A Review on Anesthetic Drug Discovery with Computer Aided Drug Design
Abstract: In contemporary medicine, anaesthesia is essential for enabling surgical procedures, pain control, and patient comfort. Finding and creating safe and efficient anaesthetics is crucial to enhancing patient outcomes and developing the medical field. In this review, we provide a comprehensive overview of anesthetic drug discovery with a focus on the integration of computer-aided drug design (CADD) methodologies. Beginning with an exploration of anesthesia mechanisms and targets, we delve into the …
Published in International Journal of Antibiotics Read article
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Harnessing Bacteria for Next-Generation Data Storage Technologies – A Review
Abstract: The exponential increase in global digital information has created a pressing need for storage technologies that are more durable, compact, and sustainable than conventional electronic media. While hard drives, solid-state drives, and cloud-based systems have transformed information management, they face severe limitations related to storage density, energy consumption, maintenance costs, and long-term preservation. Researchers have, therefore, begun exploring biological systems as alternative information storage platforms. Among these, bacteria have emerged …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Integrated Policy Approaches to Disaster Risk and Climate Change Governance: A Global Review of Institutional Strategies, Techniques, and Community Resilience
Abstract: Climate change and disaster risks have emerged as interconnected threats that demand integrated and adaptive governance systems. While both domains, disaster risk management (DRM) and climate change adaptation (CCA), have independently evolved over time, their convergence remains a complex challenge for policymakers. This review explores the multidimensional integration of policies addressing disaster and climate risks, focusing on institutional coordination, community participation, and the use of innovative governance mechanisms. Drawing insights …
Published in International Journal of Sustainability · Vol. 2, Issue 2, 2025 · pp. 27–36 Read article
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Sustainable Membrane Fabrication Using Green Chemistry Principles: A Comprehensive Review of Microwave Irradiation, Sonochemical, and Continuous Flow Methodologies
Abstract: Membrane-based separation technologies have emerged as indispensable tools in water purification, biomedical engineering, pharmaceutical processing, and environmental protection. However, conventional membrane fabrication processes often rely on hazardous organic solvents, energy– intensive steps, and environmentally taxing conditions. In response to increasing global emphasis on sustainability and regulatory pressures, green chemistry strategies have gained attention for enabling safer, energy-efficient, and eco-friendly membrane production. This review provides a comprehensive and structured analysis of …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 8–24 Read article
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Machine Learning for Finding Materials for Membranes
Abstract: Traditionally, finding and improving membrane materials has depended on trial-and-error experiments, which can take a long time, cost a lot of money, and only cover a small area. Recent improvements in machine learning (ML) have the potential to change the way membrane materials are designed by making it possible to make predictions about performance, selectivity, and stability based on data. ML algorithms can find hidden links between the structure, composition, …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 1–7 Read article
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Securing Web Applications: A Machine Learning Approach for SQL Injection Threats
Abstract: The rapid evolution and widespread adoption of the internet have significantly transformed the world, leading to an increased number of cyberattacks. Cybersecurity has become one of the most critical challenges for society, incurring substantial financial losses annually. This research focuses on SQL injection attacks, the specific threat to web applications, aiming to detect malicious queries designed to exploit vulnerabilities and access sensitive data. In recent years, the frequency of SQLi …
Published in International Journal of Information Security Engineering · Vol. 4, Issue 1, 2026 · pp. 16–22 Read article
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Advanced Lithium-Ion Battery Prognostics: A Comprehensive Review of Machine Learning Approaches for Remaining Useful Life Prediction
Abstract: The lithium-ion battery (LIB), as one of the main sources for portable power systems, has been increasingly popular owing to its widespread applications in electric vehicles, consumer electronics, aerospace and renewable energy. Despite their advantages in high energy density and long cycle life, LIBs suffer from degradation over time of aging and cycling, resulting in loss of performance, safety issues, and economic bottlenecks. Predicting their Remaining Useful Life (RUL) is …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 12–27 Read article
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Karma Yoga as a Coping Mechanism for Anxiety
Abstract: This Research article aims to investigate the effectiveness of Karma Yoga as a coping mechanism for anxiety. Karma yoga, an ancient spiritual practice originating from the teachings of the Bhagavad Gita, promotes service and selfless action devoid of expectations and fear of its result. In the Bhagavad Gita, Lord Krishna advises individuals to perform their duties without fear of its result. “Any action which is performed by a living entity …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 1, 2025 · pp. 22–27 Read article
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Advanced Security Mechanisms for AIDL Communication in High-Risk Environments
Abstract: Android Interface Definition Language (AIDL) serves as a critical component for inter-process communication (IPC) in Android systems, facilitating seamless interaction between different application components. However, in high-risk environments, such as military, healthcare, and financial systems, AIDL communication faces significant security challenges, including unauthorized access, data tampering, and privilege escalation. This paper presents a detailed review of the advanced security mechanisms designed to safeguard AIDL communication in such environments. We propose …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 1, 2026 Read article
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Parameter Identification of Vibrating MIMO Mass-Spring-Damper Mechanical Systems with Coulomb Friction
Abstract: This study presents a time-domain method for identifying parameters in multi-degree-of-freedom (DOF) linear mass-spring-damper systems that include Coulomb friction, where the friction coefficient varies within a limited range, using measurements of position and control force. For mass identification in single-degree-of-freedom (DOF) vibrating mechanical systems with stiffness and no damping but Coulomb friction, the friction term is eliminated by first derivative processing. In addition, the identification of the coefficient of friction …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 1, 2025 · pp. 20–34 Read article
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Introduction to Biological Networks and their Contributions to Systems Biology
Abstract: Biological networks provide a conceptual framework to represent and analyze the intricate interconnections among the numerous components that make up living systems. This review paper elucidates the foundational principles of networks and their diverse applications in systems biology, highlighting their crucial role in understanding the inherent complexity of biological processes. Utilizing graph theory, these networks represent entities like genes, proteins, and metabolites as nodes, with their interactions depicted as edges. …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 53–70 Read article
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Sustainable Architecture for Rural Communities: The Tanzanian Family House Model
Abstract: Sustainable rural housing in East Africa must respond simultaneously to climatic stress, water scarcity, sanitation challenges, and socio-cultural practices. This article presents the Tanzanian Family House as a climate-responsive and resource-efficient housing model developed specifically for rural Tanzanian communities. The project integrates low embodied energy materials, passive environmental strategies, and decentralized infrastructure systems to create a durable and culturally grounded dwelling that can be constructed using local skills and materials. …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 1–12 Read article
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Comparative Analysis of Serial and Parallel Robot Mechanisms for Industrial Automation
Abstract: Serial and parallel manipulators represent two major mechanical architectures in industrial automation, each with distinct strengths and trade-offs. This study presents a detailed comparative analysis of serial-chain (open-kinematic) robots and parallel-kinematic manipulators (PKMs) with a focus on industrial automation tasks. It covers kinematics, static accuracy and stiffness, dynamics and actuation requirements, control and calibration burdens, workspace and singularity behaviour, and practical industrial considerations (cost, integration, safety, maintenance). Serial robots, exemplified …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 3, Issue 2, 2025 · pp. 22–26 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Crystalline and Polymeric Interactions in Multi- layered Bulletproof Glass: A Study of Ballistic Resistance and Structural Integrity
Abstract: Bulletproof glass is engineered to withstand high-impact projectiles, offering a critical line of defense in various industries such as banking, military, and armored vehicles. This study explores the structural composition, energy absorption mechanisms, and performance characteristics of bulletproof glass when exposed to ballistic threats. The glass consists of layered constructions, often involving polycarbonate and adhesive interfaces such as polyvinyl butyral, which enhance its energy absorption and resistance to projectiles. The …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 2, 2024 · pp. 10–17 Read article
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Integrating Livestock for Enhancing Sustainability of Soil, Water and Agroecosystem: Implications from a One Health Perspective
Abstract: Livestock systems play a pivotal role in sustaining environmental health, enhancing ecosystem services, and supporting agricultural productivity. Well-managed integration of livestock into agroecosystems contributes to soil fertility through organic matter deposition, microbial stimulation, and nutrient cycling, while improving soil structure and long-term productivity. Grazing and pasture management regulate water infiltration, retention, and hydrological balance, mitigating soil erosion and enhancing water-use efficiency. Livestock also promote biodiversity by maintaining habitat heterogeneity, facilitating …
Published in International Journal of Sustainability · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Industry 4.0 and Smart Manufacturing: A Review
Abstract: This review looks at Industry 4.0 and smart manufacturing's idea, enabling technologies, implementation issues, and future prospects. Drawing on recent literature, the paper synthesizes key pillars such as the Industrial Internet of Things (IIoT), cyber-physical systems (CPS), artificial intelligence, digital twins, and additive manufacturing. It highlights integration requirements across supply chains, cyber security concerns, workforce implications, and standards activities that influence adoption. The literature survey focuses on empirical studies and …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 14–17 Read article
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Design of an Integrated Health Monitoring System on an IoT-Based Framework
Abstract: With the advent of industrialization, health ailments have become a major cause of concern owing to an inactive and fast lifestyle, polluted environments, and detrimental eating habits. However, IoT has become a boon for the health sector and humanity on account of its countless benefits, rendering improved quality of service and patient-centric care. An Integrated Health Monitoring System (IHMS) is presented in this paper. This new IoT-based framework integrates wearable …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 1–7 Read article