Search
446 articles for “expression”
-
Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
-
The Relationship between Presentation of Online Self and Conscientiousness in Emerging Adults in India
Abstract: With the rise of social media use, understanding how individuals curate their online presence and experiment with different aspects of their digital identity is crucial in determining whether their online self is an extension of their offline identity or a distinct construct. This necessitates an examination of personality traits, particularly conscientiousness, to explore its role in online self-expression. Existing research suggests that individuals with high conscientiousness tend to maintain consistency …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 38–45 Read article
-
Review paper on CRUD Operations:Using Arrays , mongoDB for data storage.
Abstract: This project presents a simple implementation of a CRUD (Create, Read, Update, Delete) web application using only arrays for data storage instead of a traditional database. Built with Node.js and Express, the app demonstrates core concepts of data manipulation and RESTful routing. It provides a lightweight framework suitable for educational purposes and early-stage prototyping where database integration is unnecessary. The system handles user- generated posts and operates fully in- memory, …
Published in Journal of Web Engineering & Technology · Vol. 12, Issue 2, 2025 Read article
-
A Review on Punjabi Language Sentiment Analysis Using Machine Learning
Abstract: In this computer era, everyone is expressing their opinions or sentiments not only physically but over the social media platforms very frequently. Earlier, English was the only language for exchanging thoughts over the web, however, in the recent times, feedbacks, surveys or comments by the users are expressed in regional languages too. This leads to the need of analyzing sentiments for better communication on the digital platforms. For example, if …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 2, 2025 · pp. 116–122 Read article
-
Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
-
The Evolution and Impact of Numbers: From Ancient Tallies to Quantum Computing: Review Article on Numbers
Abstract: Numbers are among the most fundamental constructs in human civilization, serving as the backbone of mathematics, science, technology, and virtually every aspect of daily life. They represent not only quantities and measures but also relationships, structures, and patterns that underpin the fabric of human understanding. From the earliest tallies etched on bones by prehistoric humans to the sophisticated numerical systems embedded in today’s artificial intelligence and quantum computing, the evolution …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 3, 2025 · pp. 15–19 Read article
-
Epigenetic Modifications in Health, Disease, and Precision Therapeutics (From Genome to Epigenome)
Abstract: Introduction: Epigenetic alterations play a crucial role in regulating gene expression in both normal physiological and disease states. These reversible modifications—such as DNA methylation, histone acetylation, phosphorylation, ubiquitination, and chromatin remodelling—are increasingly implicated in complex diseases including cancer and neurodegenerative disorders. Despite advances in standard therapeutic approaches, patient responses remain variable, largely due to genetic heterogeneity and epigenetic dysregulation. This highlights the need for incorporating epigenetic understanding into personalized medicine. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 Read article
-
REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Systolic-Predominant Hypertension and the Aging Heart: A Cross-Sectional Study on LVH and Cardiovascular Riskss
Abstract: Background: Systolic-predominant hypertension, defined as a systolic blood pressure ≥140 mm Hg with diastolic pressure <90 mm Hg, is the most prevalent form of hypertension in the elderly. It arises primarily due to age-related arterial stiffening and baroreceptor dysfunction. Once considered a benign outcome of aging, systolic-predominant hypertension is now recognized as a major risk factor for cardiovascular morbidity and mortality. Aim and Objective: To evaluate the cardiac status and …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 13–24 Read article
-
Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
-
Depression Detection Using AI with Chatbot Support
Abstract: Depression is a major global health concern and a significant contributor to suicide rates worldwide. India reports a high number of suicide cases, making the early detection of mental distress and depression essential for timely intervention. This research presents an AI-based system for depression detection that integrates deep learning, natural language processing (NLP), and a chatbot for user support. The system analyzes facial expressions using convolutional neural networks (CNNs) and …
Published in Research & Reviews: A Journal of Embedded System & Applications · Vol. 14, Issue 1, 2025 · pp. 01–08 Read article
-
The Role of English Language in Communication: Multidisciplinary Perspectives
Abstract: The English language performs an essential role in communication, serving as the universal medium through which people exchange data, express feelings, and build relationships. This research explores the importance of language in communication, examining its role in human interactions, the dynamics of effective communication, and the socio-cultural impact of language. Communication is a skill that involves a systematic and continuous process of speaking, listening, and understanding. We are also taught …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 1–7 Read article
-
BVC EDUPAY – SMART COLLEGE FEE PAYMENT SYSTEM
Abstract: Fee management has become a crucial component of modern educational institutions, with increasing reliance on digital platforms to handle financial transactions and administrative processes. However, students and staff often encounter challenges such as scattered fee information, manual verification procedures, delayed payment updates, and limited transparency across departments. To address these issues, BVC EduPay—a smart college fee payment system—has been developed as a centralized digital platform that consolidates academic fees, examination …
Published in Journal of Open Source Developments · Vol. 13, Issue 1, 2026 · pp. 24–34 Read article
-
Machine Learning Based Sentiment Analysis of Student Feedback in Higher Education
Abstract: Educational institutions routinely collect feedback from students to understand their perceptions of academic programs, infrastructure, and campus facilities, to improve the overall quality of the college environment. In current practice, feedback is often gathered using numerical or grade-based rating systems, which tend to oversimplify student opinions and may overlook important details related to their level of satisfaction. In contrast, open-ended textual feedback allows students to clearly express their views, concerns, …
Published in International Journal of Data Structure Studies · Vol. 4, Issue 1, 2026 · pp. 01–10 Read article
-
Effects of Reels and short videos on human mind and Academic Life
Abstract: The rapid rise of short-form video platforms such as Instagram Reels, TikTok, and YouTube Shorts has fundamentally reshaped the way people consume information and entertainment. While these applications offer quick engagement and social connection, their excessive use has raised serious concerns about their psychological and academic impacts. This research investigates the relationship between short-form video addiction, mindfulness, academic anxiety, and academic engagement among university students. Drawing upon the theoretical framework …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 2, 2026 · pp. 22–33 Read article
-
TELEVISION MEDIA AND CHILDREN: A SOCIOLOGICAL INSIGHT ON RURAL SOCIETY IN PUNJAB
Abstract: The present paper deals with to understand the media forms of television and digital media as an influential agent of socialisation in contemporary society, especially among the children. The increasing accessibility of television and digital media, especially in the rural society of Punjab, have greatly impacted the patterns of childhood socialisation, cultural norms, religious practices, attitudes, and routine behaviour. During the study it is found that television continues to occupy …
Published in International Journal of Children · Vol. 3, Issue 2, 2026 · pp. 21–34 Read article
-
Explainable Sentiment Mining Model in Mental Health Forums for Emotion Classification and Justification
Abstract: Understanding and interpreting emotions expressed in online mental health discussions plays a crucial role in enabling early detection of psychological distress and facilitating timely interventions. As individuals increasingly turn to digital platforms to share personal experiences and seek support, automated systems capable of accurately identifying emotional states can significantly assist clinicians, moderators, and support communities. This paper presents a deep learning–based sentiment mining and emotion classification framework specifically designed to …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 4, Issue 1, 2026 · pp. 22–32 Read article
-
Mathematical Model to Monitor the Transport of Bordetella Influenced by Heterogeneous Porosity in Homogeneous Gravel Depositions
Abstract: The study monitors the transport process of Bordetella in grave depositions. The study expresses the rates of depositions under fluctuation of micronutrients in the litho structures where predominant grave formation was observed. Such conditions explain the simulation values as they predominantly fluctuate with heterogeneous concentrations in deltaic formation. The study has explained the heterogeneity of deposited porosity and observed that it could not pressurize the behaviour of Bordetella transport in …
Published in Journal of Geotechnical Engineering · Vol. 6, Issue 1, 2019 · pp. 18–25 Read article
-
Transport Model of Nickel Deposition Influenced by Heterogeneous Velocity and Permeability on Saturated Soils
Abstract: Transport model of nickel was developed to monitor the variation rate of infiltration in two different formations of the soil. Its study in the formations and depositions observed to be outside the deltaic zone. These are based on other investigation carried out that verifies the types of deposited formation in the environment. Such generated information from further findings developed lots of other significant information on this deposition. The research expresses …
Published in Journal of Materials & Metallurgical Engineering · Vol. 12, Issue 1, 2022 · pp. 34–58 Read article
-
A Contribution to the Frequency and Transient Analysis of High Voltage Bushings
Abstract: The paper suggests a method for determining the frequency characteristics and transient response of capacitively graded high voltage bushings. It is based on an s-domain circuit model that describes the grading conducting foils and the insulating layers. In most cases, they are of different axial lengths. A system of simultaneous differential and algebraic equations is derived taking these differences into account. Its closed-form solution, subject to the boundary conditions, can …
Published in Journal of Power Electronics and Power Systems · Vol. 9, Issue 1, 2019 · pp. 15–26 Read article