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116 articles for “Anti-viral”
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Gene Therapy 2.0: Harnessing Cutting-Edge Technologies for Precision Medicine
Abstract: Somatic gene therapy has become the standard form of gene therapy; this creates the Gene Therapy 2.0 era. This new and distinct time consists in the new-generation genome-editing tools and markers, more efficient systems for gene delivery, and personalized medicine approaches that raise the efficacy and safety of the treatment. Base and prime editing are two types of CRISPR-based gene editing tools have provided high precision and reduced off-target effects …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Flavocillin: SarsCov2 Replicase Polyprotein 1AB Inhibitor
Abstract: Replicase polyprotein 1AB is a multifunctional protein that transcribes and replicates viral RNAs. This multifunctional protein contains protinases responsible from the cleavages of polyproteins. In this study, Flavocillin, a newly discovered potent penicillin antibiotic was docked for possible interactions with various SarsCov2 proteins by using Mcule. Although Penicillins have no antiviral effects, the docking results for Flavocillin showed that Flavocillin specifically and comptetitively inhibits Replicase polyprotein 1AB of SarsCov2. Following …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 3, 2022 · pp. 23–34 Read article
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Identification of Specificity Determining Positions through Phylogenetic Studies and Molecular Modeling of ICP27 as a Drug Target of Herpes Simplex Virus-1
Abstract: An ever-growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization can be achieved through computational approaches. Herpes simplex is an infection that is caused by a herpes simplex virus (HSV), and is one of the most common human infections transmissible to a body site. Infection with HSV can result in several diseases ranging from apparent infections …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 1, 2015 · pp. 32–43 Read article
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The effective therapeutic strategies to fight against COVID-19 in India
Abstract: In December 2019, the global pandemic coronavirus infection (COVID-19) was first detected in Wuhan, Hubei Province, Central China. It is caused by coronavirus-2, which causes severe acute respiratory syndrome (SARS-CoV-2). This was declared by World Health Organization on 11th March 2020. In India, the first case of COVID-19 infection was reported in Kerala on January 27,2020 of a 20 yr old female presented to an Emergency Department in General Hospital, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 12, Issue 1, 2022 · pp. 43–49 Read article
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Role of Unani Herbal Medicine in the Management of Acute Hepatitis (Warm Kabid Haad)
Abstract: In unani system of medicine acute hepatitis is known as Warm Kabid Haad. Almost all unani physicians described about hepatitis; its etiology, sign and symptoms, prevention and treatment in their classical texts. In conventional system viral infections of the liver are classified as hepatitis A, B, C, D and E viruses. Hepatitis A is a milder version of the disease, whereas hepatitis D is more severe. Hepatitis is of two …
Published in Research & Reviews : Journal of Herbal Science · Vol. 4, Issue 2, 2015 · pp. 9–15 Read article
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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A Review on Ocimum Sanctum (Tulsi) and its Medicinal Properties
Abstract: Ocimum sanctum (Tulsi) is one of the most important plants mentioned in Ayurveda due to its religious values and enormous medicinal properties. It belongs to Lamiaceae family. Tulsi is an inexpensive, safe and easily available plant commonly found in all the Indian Hindu households. It is a sacred plant in Hindu belief and the offering of its leaves is mandatory in ritualistic worship. Plant parts like leaves, seeds and roots …
Published in Research & Reviews : Journal of Herbal Science · Vol. 10, Issue 3, 2021 · pp. 4–7 Read article
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A study of The impact of Antibiotic Pollution and The types of Environmental Pollution It causes
Abstract: Antibiotics are essential biological drugs for human health and are the cornerstone of treating infections caused by various bacteria and viruses. However, they also pose a significant risk if misused, as each antibiotic is designed for a specific type of bacteria. Sometimes, due to the evolution of bacteria, many antibiotics have become ineffective and resistant to contamination and infection. Therefore, they can have the opposite effect, polluting the environment instead …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 41–46 Read article
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Molecular Characterization of Respiratory Viral Infections and Co-Infections in Pediatric Patients Using FilmArray™ Multiplex PCR in a Tertiary-Care Hospital, South India
Abstract: Respiratory tract infections (RTIs) are a major cause of pediatric morbidity worldwide, with viruses, such as respiratory syncytial virus, rhinovirus/enterovirus, influenza virus, adenovirus, and parainfluenza virus, contribute significantly to hospitalizations. Conventional diagnostic methods often require prolonged processing times, which can delay clinical decision-making. Rapid molecular platforms, such as the FilmArray™ Panels, offer timely and comprehensive pathogen identification. This study aimed to evaluate the prevalence, seasonal trends, and co-infection patterns of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 · pp. 57–66 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 27–41 Read article
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Plant-Derived Vaccines: A Sustainable Approach to Disease Control for Global Health
Abstract: Plant-based vaccines present a novel and environmentally responsible approach to vaccination, with significant potential for improving both human and animal health. These vaccines are safer and less expensive than traditional vaccine manufacturing methods because they use genetically modified plants to create antigens that elicit an immune response. Plant-based systems offer a potential remedy for traditional vaccines' high production costs and environmental impact, which are growing problems. Plant-derived vaccines have shown …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 17–20 Read article
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It is Not an Aberration, It is Fragment of our Correlated Viral Age
Abstract: Corona viruses are a cluster of allied contamination of germs that is originated in creatures and birds. In humanoid, corona viruses are rooted through respiratory, wheezing zone which infects the body and fluctuates from lightest to life threatening stage. The incurable classification of diseases are Severe acute respiratory syndrome-related corona virus (SARS), Middle East respiratory syndrome-related corona virus (MERS) and COVID-19. Till now, this contaminated germ disease does not have …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 8, Issue 2, 2021 · pp. 43–49 Read article
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Molecular Characterization of Circulating Rota Viral Strain causing infantile diarrhoea in Tripura, North East India
Abstract: Introduction: North Eastern India is geographically distinct from rest of India and the trend of Rota viral diarrhoea among children below 5 years of age group is not well studied yet. The Government of India introduced the oral rotavirus vaccine (ROTAVAC) in 2016 as part of the Universal Immunization Programme in different parts of India. Objective: (1). To determine the proportion of circulating Rotavirus strains causing acute viral gastroenteritis (AGE) …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 3, 2021 · pp. 6–13 Read article
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Utilize Nature’s Power: Nutraceuticals in the Fight Against Dengue
Abstract: As dengue fever continues to surge across tropical and subtropical regions, the exploration of novel therapeutic approaches is crucial. Nutraceuticals, natural bioactive compounds derived from food sources, are emerging as promising adjuncts in the fight against this viral disease. Unlike conventional treatments that primarily target symptoms, nutraceuticals offer a complementary strategy by enhancing the body’s immune defense and addressing key complications. This review highlights the diverse potential of nature’s remedies, …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 1, 2025 · pp. 19–27 Read article
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Comparison of Nested PCR and Real Time PCR of Herpes Simplex Virus Infection in Encephalitis Cases
Abstract: Introduction: Herpes simplex virus (HSV) causes a wide spectrum of clinical manifestations in the central nervous system (CNS). Presently, the development of effective antiviral therapy has resulted in an increased need for the rapid and sensitive diagnosis of HSV infections. Aims: To evaluate the usefulness of real-time PCR for diagnosing HSV encephalitis (HSE), we prospectively compared results of real-time PCR and nested PCR, using clinical samples. Methods and Material: viral …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 34–36 Read article
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The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases
Abstract: The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 46–52 Read article
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Tinospora Cordifolia (Willd.) Hook.f. & Thomson: A Review on Herbal Formulations and Health Benefits
Abstract: India has a vast variety of medicinal plants utilised as natural medicines since prehistoric times. Herbal medicine was the main form of treatment earlier in the 20th century because neither antibiotics nor analgesics were readily available. Nowadays, natural plant products are becoming more significant in clinical research since they have no side effects and have greater pharmacological response than allopathic medications. Tinospora cordifolia (Giloy or Guduchi) is a climbing shrub …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 14–19 Read article
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A Review Article on the Human Blood Groups in Relation to Healthy Longevity
Abstract: After significant discovery of the ABO blood groups of human beings by Karl Landsteiner, a number of works have been carried out on different types of blood groups like MN type, Q types, etc. and in the same time, number of researches were also carried regarding different aspects of blood groups like its genetic analysis, its inheritance, its role in paternity test, its role in blood transfusion and general physiology …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 1–5 Read article
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Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review
Abstract: A clinical condition known as thrombocytopenia is characterized by a low platelet count (less than 150 × 103/μL) in the blood, which leads to an imbalance in hemostasis and can result in multiple deadly consequences. Although the exact causes are not always known, they always lead to death by interfering with the formation of platelets and encouraging their destruction. Research demonstrates that Carica papaya leaf has special medicinal and therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 25–33 Read article