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1978 articles for “poly (ADP- ribose) polymerase -1” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Patterns of Antihypertensive Drug Utilization in a West Indies University Teaching Hospital
Abstract: Objective of this study was to determine the prescribing patterns of antihypertensive medications in specialty outpatient clinics in a tertiary care hospital of a Caribbean developing country. A retrospective prescription-based survey was conducted in the renal and cardiac outpatient clinics during the period September to December 2006. Data recorded included demographic data, antihypertensive and other drugs prescribed, duration of prescription, adverse drug reactions and side effects. A total of 285 …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 1, 2014 · pp. 26–34 Read article
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Formulation Development and Evaluation of Sublingual Tablets of Enalapril Maleate Using Co-processed Superdisintegrants
Abstract: Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 and 2:1) by co-processing and physical mixing. FTIR (Fourier transform infrared spectroscopy) and DSC (differential scanning calorimetry) spectroscopic studies …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 3, 2014 · pp. 24–39 Read article
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Determination of Gatifloxacin in Human Urine by Liquid Chromatography-Tandem Mass Spectrometry
Abstract: Gatifloxacin (GTF) is an antibiotic of the fourth-generation fluoroquinolone family that inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. A reliable, sensitive and selective isocratic reversed phase liquid chromatographic-tandem mass spectrometric (LC-MS-MS) method was developed to determine gatifloxacin (GTF) in human urine. GTF, in urine after solid-phase extraction with SPE cartridge, was analyzed on a C18 column (Symmetric 3.5 μm; 75×4.6 mm i.d) interfaced with a triple quadrupole tandem …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 1–6 Read article
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Design, Synthesis and Evaluation of Antitubercular Activity of Mannich Bases of Isoniazid-Containing Thiazolidin-4-one Rings
Abstract: Isoniazid (INH), the established antitubercular drug was selected as the lead for the design and development of antitubercular agents by many researchers. 4-thiazolidinones are well known heterocyclic compounds for their spectrum of biological activities such as antibacterial, antifungal [1], anticancer [2], antitubercular, anthelmintic, anti-inflammatory [3], analgesic [4], antithyroid, local anaesthetic, monoamine oxidase inhibition, anti-Toxoplasma gondii activity etc [5]. Modification of thiazolidinones via Mannich reaction to improve biological activity is also …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 1–12 Read article
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Titrimetric and Spectrophotometric Assay of Diethylcarbamazine Citrate in Pharmaceuticals using Permanganate as Oxidant
Abstract: Two titrimetric and one spectrophotometric methods are described for the determination of diethylcarbamazine citrate in bulk drug and dosage forms using permanganate as an oxidimetric agent. In method A, the drug solution in H2SO4 is titrated directly at 800C to a pink end point. DEC was treated with a measured excess of standard permanganate in H2SO4 medium, and after a contact time of 5 min, the residual oxidant back titrated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 3, 2016 · pp. 1–11 Read article
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Extraction of Drainage Pattern and Watershed from SRTM Data Using GIS Tools: A Case Study
Abstract: This paper proposes a fast and an inexpensive method for delineating the drainage and watershed of a sub-basin. Planning of the water resource management is evolving from simple local-scale problems toward complex spatially explicit regional scale. Such problems have to be addressed with distributed models that can compute runoff and erosion at different spatial and temporal scales. In general, watershed can range from as little as one hectare to hundreds …
Published in Journal of Remote Sensing & GIS · Vol. 7, Issue 1, 2016 · pp. 1–9 Read article
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Modeling for Transmission Loss Prediction of Different Shapes of Acoustic Muffler with an Experimental Analysis
Abstract: Muffler’s noise reduction is generally calculated by transmission loss and insertion loss. Single expansion chamber is generally used as silencing elements in intake and exhaust systems. The main aim of this paper is to study use of FEA (Finite element analysis) as well as experimental methods for various shapes of Mufflers with constant volume for transmission loss measurement. Various shapes are available for muffler like cylindrical, elliptical cylindrical, box with …
Published in Journal of Experimental & Applied Mechanics · Vol. 6, Issue 1, 2015 · pp. 57–61 Read article
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Prescription Pattern in the Department of Pediatrics in a Tribal District Hospital of Andhra Pradesh India
Abstract: In rural and tribal regions of India, pediatric population is extremely vulnerable to diseases because of lack of awareness and substandard health care facilities. Hence we planned the study to know the status of drug prescription pattern in pediatric department of a tribal district hospital. Fifty hospitalized cases were included randomly in the retrospective study. Case sheets were analyzed for prescription related parameters. Majority of cases was in the age …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 2, Issue 1, 2012 Read article
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Prescribing Patterns of Analgesics in Surgical Departments in a Tertiary Care Hospital
Abstract: Analgesics are routinely employed in the management of pain in surgical departments. Drug utilization studies evaluate the present trends of drug usage, drug expenditures, appropriateness of prescriptions and adherence to evidence-based recommendations. The Objectives were to study the prescribing pattern, approval status, inclusion in World Health Organization (WHO) essential medicines list/National List of Essential Medicines (NLEM), cost and rationality of analgesics prescribed in surgical departments. Data were collected from records …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 1, 2014 · pp. 9–16 Read article
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Ethanolic Root Extract of Jatropha curcas L. Relieves Muscle Pain in Rats
Abstract: The roots of Jatropha curcas are used traditionally to treat pain. The present study evaluated the analgesic property of ethanolic extract of Jatropha curcas (JAT) in acute and chronic muscle pain models. Acute muscle hyperalgesia was induced by injecting 3% carrageenan into the gastrocnemius muscles of rats. Twelve hours after the injection, baseline muscle hyperalgesia was measured and the rats were then treated orally with 30, 100 and 300 mg/kg/day …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 2, 2014 · pp. 5–10 Read article
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Adverse Drug Reaction Associated with Vitamins: An Analysis of Spontaneous Reports from Pharmacovigilance Programme of India Database
Abstract: The objective of this study was to describe adverse events with the use vitamins and to identify risk factors. A retrospective study was carried out from the spontaneous adverse drug reaction (ADR) reports for the period April 2011 to March 2013 by National Coordination Centre, Pharmacovigilance Programme of India (PvPI). 29 reports of vitamins were received by NCC-PvPI, which comprised approximately 0.064% of the total 45,297 reports received at NCC-PvPI. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 3, 2015 · pp. 12–18 Read article
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Combined Antibacterial Effects of Honeybee (Apis mellifera) and Garlic (Allium sativum) Extracts against Standard and Clinical Pathogenic Bacteria
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Among natural antimicrobial substances, honey and garlic were widely used and investigated separately. But their synergistic antibacterial effect was not studied. The objective of this study was to investigate synergistic antimicrobial effect of combination of honey and garlic against pathogenic bacteria. The antimicrobial activity of mixture of honey and garlic, honey and garlic extract alone against Salmonella NCTC 8385, Listeria monocytogenes (ATCC …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 1, 2013 Read article
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Evaluation of Nucleic Acid Amplification Method in Diagnosing Enteric Fever in Children
Abstract: The comparison of three detection methods (Widal test, Typhi dot and Nested PCR) for diagnosis of typhoid fever was done in laboratory where gold standard was either Widal positive or Typhi dot positive or both positive. A nested polymerase chain reaction (PCR) specific for Salmonella enteric serovar typhi was used for the detection of the pathogen in blood samples. Total 52 patients with clinical suspicion of typhoid fever were recruited …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 1, 2013 Read article
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Prevalence of Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) in Laboratory Environment
Abstract: Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are widely distributed in the world and pose a major public health problem. It is one of the important organisms that are implicated in hospital acquired infections. These pathogens are responsible for morbidity and mortality especially in immunocompromised patients. In many, the organism is present as normal flora in healthy individuals. This study was undertaken to determine the prevalence of S. aureus and …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 1, 2013 Read article
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HBsAg Prevalence and Determinant Risk Factors among Voluntary Counseling and Testing Clients Visiting Gondar Health Center, Northwest Ethiopia
Abstract: Globally, an astounding number of people are infected with HBV, HCV and HIV. Due to shared routes of transmission, HBV and human immunodeficiency virus co-infection is common and is an emerging concern in the clinical management of patients because of increased mortality, accelerated hepatic disease progression, and the frequent hepatotoxicity caused by hepatitis B virus. The aim of this study was to assess the prevalence and risk factors of HBsAg …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 15–20 Read article
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Changes in Physicochemical, Biochemical and Microbiological Quality Parameters of Green and Black Tea during Storage
Abstract: The shelf life of different packaged tea is very important concern of tea industry. Thealuminium packaging is better than any other packaging to determine best before use. Thusdifferent times are applicable for both green and black tea to keep their physicochemical,biochemical and microbiological parameters. The rate decrease of quality parameters(according to FSSAI regulation) are higher in Green tea (sharp changes started from 3 rdmonths) than Black tea (gradual changes) in …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 2, 2017 · pp. 26–31 Read article
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Reinforcing the Social Domain towards Pacifism in Gobind’s Way
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Guru Gobind Singh, the sikh commander was a lean conceptual soldier who laid the concept of synergy as illustrated by one of the earlier works of authors. Thus, called a guru by karma and also by virtue of being born as Guru Teg Bahadur’s son - the 9th guru of their dynasty, Guru Gobind Singh saw through the sinful rule to prepare …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 2, Issue 1, 2012 Read article
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Nigeria-Zimbabwe Bilateral Relations: Issues and Challenges
Abstract: Nigeria-Zimbabwe bilateral relations were struck in the early 1980s when Zimbabwe attained political independence during the administration of Alhaji Shehu Shagari. The diplomatic relations between the two countries were warm and cordial in the period 1980–2004. The objective of this paper is to examine the issues that have resulted to the low ebb in Nigeria-Zimbabwe bilateral relations in recent years. Secondary data were utilized in this paper. Books, Journals, magazines …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 4, Issue 2, 2014 · pp. 31–35 Read article
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A Descriptive Approach on the Relationship between Facebook and the Well-Being of Undergraduate College Students, Mekelle, Ethiopia
Abstract: In recent years, online social-networking sites have achieved notable popularity among college students. Online social networking sites, such as Facebook, Google+, and Bebo, have grown popularity in recent years and they provide an exciting new area of study in the field of psychology. A survey study under descriptive research, the populations included in the study were undergraduate’s students (N= 400) from different Departments of Mekelle University, Ethiopia, Male 232(58%) and …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 6, Issue 2, 2016 · pp. 1–7 Read article
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Analysis of Bore and Pond Waters at Storage Used for Drinking in Villages of Coimbatore for Determination of Coliforms
Abstract: The aim of the study was to identify the MPN Index of the water samples that were available for drinking purpose in selected villages. The water that was used for drinking should be free from any form of contamination in order to prevent ourselves getting infected by water borne diseases. The detection of Coliforms by this method helps in the identification of either the water shall used for drinking or …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 Read article