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1314 articles for “Medication”
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Insilico Structural Analysis and Homology Modeling of Crustin Protein from Fiddler Crab Species
Abstract: In terms of biomass and ecological or economic importance, the crustacea are the largest, most noticeable, and possibly, the most significance group of marine or aquatic arthropods. Because of their enormous commercial value and the necessity to prevent disease outbreaks in the shellfish aquaculture industry, decapods are the experimental animals of choice for practically all biological studies involving immune responses. Antimicrobial host-defense peptides (AMPs) are major components of metazoan immunity, …
Published in International Journal of Cheminformatics · Vol. 1, Issue 1, 2023 · pp. 1–7 Read article
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Computer Aided Drug Designing for Targeted Drug Delivery Systems
Abstract: The discovery and development of a contemporary sedate is widely acknowledged as an extremely difficult task that requires significant resources and effort. Therefore, computer-aided medication design techniques are widely utilized today to increase the productivity of the drug discovery and development process. Among structure-based and ligand-based drug design approaches, both recognized for their efficiency in drug discovery and development, various CADD (Computer-Aided Drug Design) techniques are evaluated based on specific …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 34–41 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Determining the Root Causes of Complications in Hemodialysis Maintenance Therapy
Abstract: As with peritoneal dialysis and kidney transplantation, hemodialysis has been considered one of the most effective therapies for the replacement of kidney function. While this helps to save patients with the disease by decreasing morbidity /mortality/ rates, this medication has some side effects. These may manifest during the dialysis process alongside the ongoing treatment. Avoiding these barriers becomes crucial for improving the patients’ prognosis in this context.We are going to …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 27–47 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Multi-functional UAV for Disaster Response and Management
Abstract: Unmanned Aerial Vehicles (UAVs), commonly known as drones, have become integral across diverse fields such as agriculture, surveillance, and defense, with expanding roles in critical operations like search and rescue and post-disaster management. Despite their versatility, current UAVs encounter challenges in disaster response due to limitations in flight time, costs, and accuracy, particularly in dynamic weather conditions. The UAV is equipped with features essential for disaster site surveillance, human detection, …
Published in Journal of Aerospace Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 1–6 Read article
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Implementing Quality by Design (QbD): Strategies, Challenges, and Best Practices across Industries
Abstract: The present comprehensive review investigated the dynamic landscape of quality standards within the pharmaceutical sector, with a primary focus on the implementation and impact of Quality by Design principles. It illuminated the multifaceted challenges encountered by pharmaceutical companies in upholding stringent quality standards amidst evolving regulatory requirements and complex manufacturing processes. By embracing Quality by Design principles, the industry aims to foster a proactive and systematic approach to product development …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 28–36 Read article
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Application of Nanotechnology in Rasaushadhi Preparations for Nanoparticle Synthesis—A Comparative Review
Abstract: Nanotechnology—a constantly evolving branch of science and technology—reveals great potential for the early diagnosis, care and mitigation of numerous illnesses. In the field of Ayurvedic medicine, a variety of herbal, herbo-mineral and herbo-metallic compositions are used in formulations namely Bhasma, Kupipakwa Rasayana, Kharaliya Rasayana since a long era. To minimize the particle size of the substance (nanoparticles), procedures such as Shodhana, Nirvapa, Mardana, Bhavana, Marana, and others are carried out. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2024 · pp. 1–8 Read article
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Cannabinoids as Nutritional Supplements: Exploring The Potential Health Benefits and Regulatory Landscape
Abstract: Cannabinoids, the bioactive compounds derived from the Cannabis sativa plant, have garnered increasing interest for their potential role as nutritional supplements. This abstract provides a succinct overview of cannabinoids as nutritional supplements. This review delves into the multifaceted aspects of cannabinoids, particularly their interaction with the endocannabinoid system (ECS) and their potential health benefits. The exploration begins by elucidating the intricate relationship between cannabinoids and the ECS, a vital regulatory …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 48–53 Read article
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Characterization of Synthesized Heterocyclic Oxadiazole Derivatives Using Mass, UV, IR, and NMR Spectroscopy, Among other Spectroscopic Techniques: Review
Abstract: The current study synthesized and assessed 3-heteroarylazo 4-hydroxy coumarin derivatives' initial antibacterial activities in vitro against four distinct pathogenic bacterial strains, including Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus. Ampicillin, a common medication, was used to compare each compound's antibacterial properties. UV, IR, 1H NMR, mass spectroscopy, and X-ray diffraction examinations were used to analyze the compounds. By using UV–vis spectra, the solute-chromic behavior of these compounds was …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 1, Issue 1, 2023 · pp. 28–33 Read article
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Performance Analysis of Deep CNN Architectures
Abstract: A Convolutional Neural Network (CNN) is an artificial neural network renowned for its remarkable ability to handle large image datasets effectively, particularly excelling in tasks such as image recognition and classification. The fundamental structure of a CNN relies on mathematical convolution operations, comprising essential components such as convolutional layers, activation functions, pooling layers, and fully connected layers. These components work synergistically to extract and learn hierarchical features from input data, …
Published in Journal of Communication Engineering & Systems · Vol. 14, Issue 2, 2024 · pp. 1–8 Read article
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Recovery of Mycelial Biomass of Agaricus Bisporus, Pleurotus Ostreatus, Ganoderma lucidum, Hieracium Erinaceus: A comparative Study
Abstract: Mushrooms are the spore-bearing fruiting body of fungi which has a significant potential for numerous applications like pharmaceuticals, textile industry, bioremediation, soil management, alternative to toxic packaging materials and environment sustainability. Mushrooms generally belongs to the class Basidiomycota or Ascomycota. They are typically made of hyphae, the tiniest threads which comprises most fungi. Mycelia are tiny thread like structure which help in making vegetative part of fungus. In this study, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 12–18 Read article
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Current Drugs Target the EGFR
Abstract: Cancer is a devastating disease, but there have recently been significant advancements in therapy that have identified EGFR and its related proteins as valuable indicators and targets for treatment. The ERBB receptor tyrosine kinase superfamily includes EGFR, which is a transmembrane glycoprotein. When the EGFR receptor interacts to its particular ligand, EGF, it causes tyrosine residues to be phosphorylated and forms receptor dimers with other members of the receptor family. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 1–8 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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A Secure and Transparent Voting System Leveraging Ubiquitous Computing and Blockchain Technology
Abstract: Ubiquitous computing and blockchain technology are two pivotal innovations driving significant changes in the digital world. This article explores the intersection of these technologies, analyzing how their combination can unlock new opportunities and address existing challenges. Ubiquitous computing envisions seamlessly integrating computing capabilities into everyday objects and environments, aiming to enhance user experience and efficiency. Meanwhile, blockchain technology, known for its decentralized and secure nature, offers robust solutions for transparency, …
Published in Journal of Advancements in Robotics · Vol. 11, Issue 2, 2024 · pp. 9–13 Read article
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Different Aspects of the Role of AI in Developed and Developing Countries and the Indian Economy
Abstract: Nothing is permanent; change is a constant in our world, often bringing both positive and negative effects. Modern technology is now ubiquitous, benefiting countries while also posing challenges. The critical question is the impact of artificial intelligence (AI) in the future. AI concepts have roots in ancient India, seen in the stories of epics and Upanishads, such as the Pushpak Viman in Ramayana and Sanjay’s divine vision in Mahabharata. This …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 11, Issue 2, 2024 · pp. 1–11 Read article
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A Study of Clinical Education Practice of Clinical Instructors Accompanying Nursing Students of Kashmir Division, Deployed for Clinical Posting in SKIMS Soura
Abstract: Introduction: Clinical education also called clinical teaching, is one of the practical based approaches whereby the students are exposed to natural and practical settings. Clinical education refers to the process of educating and training healthcare professionals, such as medical students, nurses, or other allied health professionals, in a real-world clinical setting. This form of teaching is crucial for translating theoretical knowledge into practical skills and fostering the development of clinical …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Exploring Diabetic Retinopathy from an Ayurvedic Lens: Insights Leveraging Bioinformatics
Abstract: Diabetic retinopathy is one among the target diseases for VISION 2025. The huge cost required for treatment, economic loss due to absenteeism from work etc... has made it as a great public challenge. Therefore it is in need of the hour to address the issues of diabetes mellitus with its complication Diabetic Retinopathy with all seriousness and it is quite essential to search for a affordable medical care for the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 45–51 Read article
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Heart Disease AI-based Prediction: A Comparative Analysis
Abstract: The present investigation looks at how well various machine learning algorithms predict cardiac disease. Since heart disease is one of the major causes of death worldwide, early detection and precise diagnosis are essential for managing and treating the condition. Our goal is to enhance diagnostic processes and improve patient outcomes by leveraging machine learning techniques. Six widely-used machine learning algorithms are evaluated in this research paper. These algorithms were selected …
Published in Trends in Mechanical Engineering & Technology · Vol. 14, Issue 2, 2024 · pp. 21–29 Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article