Search
1209 articles for “module”
-
Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
-
Optimizing Multi-Cloud Infrastructure: Advanced Bash-Based Automation for Automated Security Patching and Health Monitoring in Hybrid Linux Environments
Abstract: The proliferation of multi-cloud and hybrid Linux environments has introduced significant operational complexity, particularly in maintaining security compliance and system reliability across diverse infrastructure silos. Traditional patch management approaches, relying on manual interventions or disparate vendor-specific tools, suffer from latency, configuration drift, and limited visibility. This article presents a novel, lightweight automation framework constructed entirely in advanced Bash scripting to address automated security patching and real-time health monitoring across hybrid …
Published in Journal of Advances in Shell Programming · Vol. 13, Issue 2, 2026 Read article
-
Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 33–47 Read article
-
Nutrient Sensing and Microbiota Crosstalk: Driving Determinants Shaping Metabolic Stability and Adaptive Physiology for Animal Health
Abstract: Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
-
Design and Development of a Smart Automated Packaging System for Poultry Drumsticks
Abstract: The present work aims to design and implement an automated packaging system for poultry drumsticks that enhances operational efficiency, product quality, and adaptability. The integrated system offers a solution that complies with industrial quality and safety standards by sorting products, getting accurate weighing, and efficiently portioning food into 1-kilogram standardized units. By effectively reducing human involvement, operational inefficiencies, workforce requirements, and contamination hazards, the automation system becomes sufficiently adaptable to …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 4, Issue 1, 2026 · pp. 1–7 Read article
-
Advancements in Battery Storage Technology for Renewable Energy Systems: Improving Reliability and Efficiency of Sustainable Energy
Abstract: Advances in battery storage technology are critical to improved reliability and efficiency of renewable energy systems, underpinning a sustainable energy future. Innovations exist in many different kinds of battery technologies- being developed and tested, and the leading contenders include innovations such as lithium-ion and sodium-ion, and much newer entrants like the solid-state and lithium-sulfur batteries. These developments respond to growing needs for sustainable solutions towards better integration of intermittent renewable …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 17, Issue 2, 2026 Read article
-
Design and Implementation of an Automatic Rain Sensing Wiper System Using SEN0545 Sensor and Raspberry Pi Pico W
Abstract: This study presents the design and development of an intelligent, automatic rain-sensing wiper system designed to enhance vehicle safety. The system utilizes a SEN0545 capacitive rain sensor, integrated with internal signal processing, and a Raspberry Pi Pico W microcontroller as its central control unit. The proposed approach enables non-contact and corrosion-free rain detection, ensuring reliable performance under varying environmental conditions. Based on the detected rainfall intensity, the controller dynamically adjusts …
Published in Trends in Electrical Engineering · Vol. 16, Issue 2, 2025 · pp. 16–25 Read article
-
Comprehensive Review of the Fundamental and Functional Properties of Crystalline Materials
Abstract: Crystalline materials, characterized by their highly ordered atomic arrangements, serve as the backbone of modern engineering and technology. This review provides a detailed examination of their diverse properties, categorized into mechanical, thermal, electrical, and optical domains. We analyze fundamental mechanical parameters such as the elastic modulus, yield strength, and fracture toughness, alongside functional behaviors like fatigue and creep. The discussion extends to thermal transport and expansion, electrical conductivity and resistivity, …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 1, 2026 · pp. 20–24 Read article
-
Polymer Composite-Enabled UAV Platform for Edge AI-Based Precision Agriculture: A System-Level Evaluation
Abstract: This study investigates the system-level role of commercially available polymer composite materials in enabling lightweight and energy-efficient unmanned aerial vehicle (UAV) platforms integrated with edge artificial intelligence for real-time agricultural monitoring. Rather than developing or experimentally characterizing new composite materials, the work evaluates fiber-reinforced polymer (FRP) composites and epoxy-based laminates as enabling structural components whose established properties support UAV performance in precision agriculture. Their high strength-to-weight ratio, corrosion resistance, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 218–240 Read article
-
Multi-Scale Analysis of Polymer Based Energy Storage Systems for High Performance Battery Applications
Abstract: The energy storage systems based on polymers are becoming promising materials for the next generation of high performance batteries because of their excellent mechanical flexibility, improved safety, and favorable electrochemical properties. Even with computational tools in Python, polymer-based energy storage systems remain plagued by poor ionic conductivity, complicated electrochemical reactions and potential thermal runaway. Therefore, a multi-scale model is proposed to improve battery performance, thermal stability, reliability, and large-scale deployment …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1035–1048 Read article
-
Machine Learning Based Optimization of Polymer Structure Property Relationships in Composite Material Systems
Abstract: In modern engineering applications, polymer-based composite materials have garnered a lot of attention because of their lightweight nature, high strength-to-weight ratio, and changing physical features. In order to maximize the relationships between polymer structure and properties in composite materials, this study suggests a strategy based on reinforcement learning (RL). The research utilized the Polymer Composite Properties Dataset, which contains 12,700 records associated with polymer matrices, reinforcement fillers, interfacial bonding characteristics, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 242–255 Read article
-
Autonomous 6G Physical Layer Architectures for Space-Air-Ground Integrated Networks
Abstract: The emergence of sixth generation (6G) wireless systems calls for a significant shift away from conventional deterministic communication models. As communication infrastructures evolve into Space- Air-Ground Integrated Networks (SAGIN), traditional physical layer (PHY) techniques struggle to operate effectively under the severe Doppler effects and long propagation delays associated with space environments. This paper examines the role of artificial intelligence embedded directly within the 6G transceiver architecture to enable ultra-reliable and …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 13, Issue 2, 2026 · pp. 21–31 Read article
-
Integrate AI and IoT to Develop Sustainable Polymer Structural Materials Processing Optimization: Enabled Monitoring Strategies for Performance and Lifecycle Assessment
Abstract: The need for long-lasting structural polymer materials that are both environmentally friendly and highly mechanically effective is driving demand for these materials as the industrial sector continues to grow. Optimizing processes, saving energy, detecting faults, and monitoring structures are all hindered by conventional polymer manufacture. This study suggests an AI-IoT system for environmentally friendly production of structural polymer materials to get around these problems. Tools for evaluating system performance and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 169–192 Read article
-
A Survey on Hydrogen Storage System using Composite Material and its Alloys
Abstract: The transition to a carbon-neutral energy landscape hinges on the ability to store hydrogen safely, densely, and reversibly. While high-pressure tanks and cryogenic vessels dominate today’s infrastructure, solid-state storage in metallic alloys offers a compelling alternative by combining high gravimetric capacity with intrinsic safety to form a composite material. This work presents a systematic investigation of a family of reversible hydrogen-absorbing composite material alloys—principally Mg-based intermetallics (Mg₂Ni, MgFeMn) and TiV-based …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 · pp. 35–42 Read article
-
Investigation on mechanical performance of 3D printed PLA-Kraft Lignin composites
Abstract: Bio-based polymer composites are becoming more popular due to the growing need for sustainable and biodegradable materials in additive manufacturing. PLA-kraft lignin composites were created and their mechanical performance in fused deposition modeling (FDM) applications was assessed in this work. Polylactic acid (PLA) was mixed with Kraft lignin, a sustainable by-product of the paper industry, at weight percentages of 0%, 1%, 3%, 5%, and 7%. Melt blending was utilized to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1002–1015 Read article
-
Generative Design of Bioactive Orthopedic Composites for Fracture Repair Using an Integrated Conditional GAN–Transformer Framework: A Multi-Objective Approach
Abstract: Orthopedic composite implants for fracture repair must simultaneously satisfy conflicting mechanical and biological demands: high fracture toughness, sufficient compressive stiffness, and bioactive surface chemistry enabling osteoblast adhesion and mineralization. Existing design approaches rely on trial-and-error experimentation, yielding sub-optimal trade-offs between these objectives. This paper presents an integrated conditional Generative Adversarial Network–Transformer (cGAN-T) framework for fully computational, multi-objective generative design of hydroxyapatite (HA)-reinforced polymer composite microstructures targeting Orthopedic fracture repair. A …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 21–35 Read article
-
Earthquake Detection and Monitoring System
Abstract: Earthquakes continue to be one of the major natural hazards affecting human life and infrastructure. The development of affordable monitoring systems is essential for increasing preparedness and reducing the impact of such disasters. This work presents an Earthquake Detection and Monitoring System based on a vibration sensor and Arduino controller. The system continuously observes ground movements and evaluates the detected vibration levels against a predefined threshold. Whenever unusual vibrations are …
Published in Journal of Instrumentation Technology & Innovations · Vol. 16, Issue 2, 2026 Read article
-
Stretchable Elastomer–PCM Composites with Bluetooth-Enabled Temperature Monitoring for Wearable Healthcare IoT Devices
Abstract: The rapid advancement of wearable healthcare technologies has created a growing demand for multifunctional polymer composites capable of simultaneously providing mechanical flexibility, thermal energy management, electrical conductivity, sensing capability, and wireless communication. In this study, a stretchable elastomer-based polymer composite integrated with a phase-change material and a Bluetooth Low Energy temperature monitoring system was developed for wearable healthcare Internet-of-Things applications. The polymer composite was fabricated using an Ecoflex silicone elastomer …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 241–257 Read article
-
A Review on Automatic Railway Gate Control System
Abstract: Railway transportation is one of the most efficient and widely used modes of transport; however, safety at level crossings remains a critical issue, especially at unmanned or manually operated gates. A significant number of accidents happen as a result of human carelessness, insufficient coordination, and postponed gate operations. To address these issues, the Automatic Railway Gate Control System has been created as a viable solution to improve safety and minimize …
Published in Journal of Control & Instrumentation · Vol. 17, Issue 2, 2026 · pp. 1–7 Read article
-
Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 47–58 Read article