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837 articles for “Clinical”
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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A Systemic Review: Pithecellobium dulce (Jangal Jalebi)
Abstract: Pithecellobium dulce (Roxb.) Benth., commonly referred to as Jangal Jalebi, Vilayati Babul, or Manila Tamarind, is a versatile tree in the Leguminosae (Fabaceae) family. It is commonly found in tropical and subtropical areas and is valued for its ecological, medicinal, and nutritional benefits. The plant is rich in a variety of bioactive compounds, including flavonoids, alkaloids, phenols, glycosides, tannins, saponins, terpenoids, and steroids, which enhance its pharmacological potential. Different extracts …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 14–20 Read article
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Impact Of Nurse-Led Pain Management Protocol On Postoperative Recovery Outcome
Abstract: Postoperative pain remains a critical determinant of recovery outcomes, influencing patient satisfaction, complication rates, and overall healthcare utilization. Nurse-led pain management protocols have emerged as an evidence-based strategy to enhance postoperative care through continuous assessment, individualized interventions, and multidisciplinary collaboration. This article explores the impact of nurse-led pain management on postoperative recovery outcomes, including pain reduction, early mobilization, decreased hospital stay, and improved patient satisfaction. Evidence from recent studies demonstrates …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 2, 2026 Read article
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Uncontrolled Cell Growth and Human Health: A Comprehensive Exploration of Cancer
Abstract: Cancer is a diverse category of diseases defined by the uncontrolled proliferation and spread of aberrant cells. It remains the major cause of morbidity and mortality worldwide. This article presents an overview of the various forms of cancer, such as carcinomas, sarcomas, lymphomas, and leukaemia, emphasising their distinct causes, symptoms, and risks. Early detection and diagnosis are emphasized as key to enhancing treatment outcomes. The article further provides an in-depth …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 1–23 Read article
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Biopolymer Hydrogels: Patent Insights and Emerging Technological Trends
Abstract: Hydrogel biopolymers have become a valuable resource for next-generation functional materials due to their inherent properties, including compatibility with biological systems, environmental degradability, and minimal toxicity. Intelligent gels that respond to changes in temperature, pH, or ionic strength have various applications across industries like pharmaceuticals, biomedical engineering, and the food sector. This review systematically compiles findings from patent disclosures and non-patent literature to highlight recent trends in biopolymer-based hydrogel research, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 916–924 Read article
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Emerging Trends in Horticultural Crops: Role of Date Fruit in Promoting Urinary and Kidney Health
Abstract: Dates, or Phoenix dactylifera L., have been widely consumed in different cultures, both as a food source and for their health benefits. Whereas dates have been reported extensively to improve cardiovascular, gastrointestinal, and metabolic function, their role in urinary tract and renal health has received lesser attention in mainstream nutritional sciences. This review systematically evaluates and synthesizes the current literature on the potential effects of dates to promote urinary health …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 1, 2026 · pp. 24–32 Read article
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Today’s Status of Digital Resources in Medical College Libraries
Abstract: Digital resources have become integral to the advancement of medical education and research, enabling access to current scientific evidence, clinical guidelines, e-books, e-journals, and multimedia learning tools. Medical college libraries worldwide are transitioning from traditional print repositories to hybrid digital knowledge hubs. This transformation is driven by the evolution of Information and Communication Technology (ICT), rising expectations of learners and educators, institutional mandates for evidence-based practice, and the diffusion of …
Published in Journal of Advancements in Library Sciences · Vol. 13, Issue 1, 2026 · pp. 85–94 Read article
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Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Signal Drift Compensation in Polymer-Based Wearable Biosensors Using Data Processing Techniques
Abstract: Polymer-based wearable biosensors have emerged as promising platforms for continuous physiological monitoring due to their mechanical flexibility, low operating voltage, and compatibility with soft biological interfaces. However, their long-term deployment remains challenging because of signal drift caused by polymer ageing, hydration–dehydration cycles, ionic trapping, and environmental variations. These effects introduce baseline fluctuations and sensitivity degradation, which compromise the reliability and interpretability of physiological measurements. This study proposes a data-processing–driven framework …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 197–207 Read article
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Mental Health Nursing Interventions in Schizophrenia Care: Effectiveness of Nurse-Led Strategies in Managing Schizophrenia Disorder
Abstract: Schizophrenia is a chronic and severe mental disorder characterized by disturbances in thought, perception, emotion, and behavior that significantly impair an individual’s functioning and quality of life. Mental health nurses play a pivotal role in the management of schizophrenia through comprehensive, patient-centered, and evidence-based interventions. This article critically examines the effectiveness of nurse-led strategies in managing schizophrenia disorder, focusing on pharmacological support, psychosocial interventions, psychoeducation, therapeutic communication, relapse prevention, and …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 1, 2026 Read article
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Adaptive Drift Correction in Polymer-Based Wearable Biosensors via Data-Driven Signal Modeling
Abstract: Polymer-based wearable biosensors have emerged as a promising technology for continuous health monitoring due to their mechanical flexibility, biocompatibility, and suitability for long-term physiological interfacing. However, prolonged exposure to biofluids, environmental variability, and mechanical deformation introduces signal drift, which significantly degrades measurement accuracy and limits clinical reliability. This paper presents a data-driven methodology for compensating signal drift in polymer-based wearable biosensors using adaptive signal processing and machine learning techniques. The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 131–139 Read article
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A Study on High-Risk Pregnancy and Its Management: Role of Obstetric Nurses in Improving Maternal and Fetal Outcomes
Abstract: High-risk pregnancy is a major challenge in maternal and neonatal healthcare and is associated with increased morbidity and mortality among mothers and new-borns, particularly in developing regions where access to quality healthcare services remains uneven, this article examines the concept, classification, risk factors, pathophysiology, and management of high-risk pregnancy with a strong focus on the role of obstetric nurses in improving maternal and fetal outcomes, obstetric nurses play a central …
Published in International Journal of Midwifery Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 26–43 Read article
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Comparative Analysis of the Structural Integrity and Dimensional Stability of Additively Manufactured Biopolymers vs. Thermoformed PETG: A 1-Year Retrospective Study on Polymer Performance in Orthodontic Applications
Abstract: Objective: This study aimed to evaluate the long-term dimensional accuracy and structural performance of direct 3D-printed biopolymers compared to conventional vacuum-formed Polyethylene Terephthalate Glycol (PETG) composites. The investigation focused on how different polymer processing methods (additive manufacturing vs. thermoforming) influence material thinning and resistance to occlusal stress. Methods: A retrospective analysis was conducted on 60 cases (n = 60) of post-orthodontic maintenance. The sample was divided into two cohorts: Group …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 140–146 Read article
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Machine Learning in Nuclear Medical Applications: A Review of Research Frontiers
Abstract: Nuclear medicine, encompassing PET, SPECT, and targeted radionuclide therapy, generates high-dimensional, quantitative data uniquely suited for machine learning (ML) analysis. This review synthesizes current research applications of ML across six key domains. Positron emission tomography (PET), single-photon emission computed tomography (SPECT), and targeted radionuclide therapy are examples of nuclear medicine modalities that generate high- dimensional, quantitative datasets that are particularly well-suited for machine learning (ML)-driven analysis. These imaging methods provide …
Published in Journal of Nuclear Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 19–24 Read article
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Ilaj bil-Ma’ (Hydrotherapy) as a Regimenal Modality in Pain Management: Conceptual Foundations in Unani Medicine and Modern Correlation
Abstract: Waja‘ (pain) is one of the most common clinical complaints encountered worldwide and remains a leading cause of disability, impaired functional capacity, and diminished quality of life. In the Unani system of medicine, pain is not considered merely a symptom but a significant manifestation of disturbed physiological balance. Classical Unani scholars describe pain as arising from derangement in Mizāj (temperament), imbalance of Akhlāṭ (humours), Sudad (obstruction within bodily channels), Waram …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 · pp. 12–19 Read article
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Influence of Antibiotic Promotion Practices on Pharmacovigilance and Resistance Reporting Patterns
Abstract: The global escalation of antimicrobial resistance (AMR) has emerged as a critical public health crisis, undermining decades of therapeutic advancements. While inappropriate prescribing and misuse of antibiotics are widely acknowledged contributors, the role of pharmaceutical promotion practices remains underexplored in influencing prescribing behaviors and downstream pharmacovigilance systems. This review critically examines how antibiotic promotion strategies – ranging from direct physician engagement to digital marketing – affect adverse drug reaction (ADR) …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 1–11 Read article
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article
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Study of the Antibacterial Activity of Artemisia Absinthium against E. coli bacteria Isolated from Urinary Tract Infections
Abstract: Twenty clinically diagnosed samples were collected using transport medium swabs from the operating room at Al-Amal Specialized Laboratory in Iraq between November 2025 and February 10, 2026. Antibiotic susceptibility testing was performed on the 20 Escherichia coli samples. The results showed a clear difference in the bacterial isolates' response to the tested antibiotics. Imipenem demonstrated the highest inhibition rate, reaching 24.55% (100%), compared to the other antibiotics used in the …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 17–25 Read article
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Gold Nanoparticle Size, Biodistribution, and Toxicity: Insights from DualEnergy CT
Abstract: Dual-energy and spectral computed tomography (CT) have emerged as powerful platforms for noninvasive, quantitative mapping of nanoparticle biodistribution in vivo. By exploiting the energy-dependent attenuation profiles of high-atomic-number (high-Z) materials, these systems enable material decomposition and element-specific imaging, thereby distinguishing nanoparticle signals from those of soft tissues and conventional iodinated contrast agents. Photon-counting spectral CT further enhances this capability by binning individual photons into multiple energy channels, improving spatial resolution, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article