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401 articles for “profiling”
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Developing a Comprehensive Framework for User and Entity Behavior Analytics (UEBA): Integrating Advanced Machine Learning and Contextual Insights
Abstract: User and Entity Behavior Analytics (UEBA) has emerged as a crucial approach in modern cybersecurity for detecting and mitigating insider threats, compromised accounts, and other malicious activities within organizational networks. However, existing UEBA frameworks often face challenges in scalability, detection accuracy, and response effectiveness. This research work proposes a novel framework for UEBA that aims to address these limitations and enhance threat detection and response capabilities. The framework integrates advanced …
Published in Journal of Communication Engineering & Systems · Vol. 14, Issue 2, 2024 · pp. 20–32 Read article
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Origin and Development of Forensic Science and Branches of Forensic Science
Abstract: Forensic science is like the Sherlock Holmes of the real world, blending scientific expertise, legal acumen, and investigative prowess to crack cases and bring justice to the forefront. It’s essentially the art of using scientific methods to untangle the mysteries of crimes and legal disputes. Picture this: a team of experts delving into the minutiae of evidence – from DNA samples to fingerprints, from chemical analyses to digital footprints – …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 1, 2025 · pp. 19–27 Read article
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A Review on Nanosponges Drug Delivery System
Abstract: The main issue that the researchers are dealing with is targeted medication delivery to locations. Crosslinking polymers produce nanosponges, which are three-dimensional drug delivery systems at the nanoscale. They have the benefit of having a large capacity to carry different-sized medications. There are numerous sizes and shapes for nanosponges. Compared to alternative delivery methods, nanosponges are preferable because they may offer a regulated medication release pattern with targeted Medication administration. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 68–76 Read article
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Computational Analysis of Non-Newtonian Blood Flow through Bifurcated Coronary Artery: Insights into Hemodynamics and Wall Shear Stress
Abstract: This abstract presents a study on the computational fluid dynamics (CFD) simulations of blood flow through a bifurcated coronary artery using non-Newtonian fluid model. The objective of this study is to investigate the hemodynamic characteristics in Bifurcated Coronary artery. The methodology involved the utilization of ANSYS SpaceClaim software for creating a geometric model of the bifurcated coronary artery. A mesh independent study was conducted to ensure the accuracy and reliability …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 160–168 Read article
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Next-Gen Techniques for Bottleneck Detection in High-Performance Computing
Abstract: Modern computing systems face new challenges in bottleneck detection and mitigation due to their increasing complexity which stems from multi-core architectures alongside distributed platforms and real-time processing needs. Traditional methods like hardware profiling and static analysis which used to work well now struggle to keep up with the changing conditions of dynamic system behaviors and diverse computing environments along with variable workload patterns. The current limitations restrict their capability to …
Published in Recent Trends in Parallel Computing · Vol. 12, Issue 2, 2025 · pp. 09–14 Read article
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Preoperative Use of Midazolam vs Dexmedetomidine for Anxiolysis in Day-Care Surgery
Abstract: Surgical procedures trigger significant fear and anxiety that can adversely affect physiological responses and recovery outcomes. This prospective, randomized, double-blinded clinical trial compared the anxiolytic efficacy and safety of intravenous midazolam and dexmedetomidine in 60 patients undergoing day-care surgery. Primary outcomes included anxiety scores measured by STAI and sedation assessed by the OAAS scale at multiple perioperative time points. Secondary outcomes assessed in the study included detailed evaluation of hemodynamic …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 7–12 Read article
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Comparative Study of Uniform and Non-Uniform Beams Resting on Bi-Parametric Foundation Under Harmonic Load with Time Dependent Boundary Conditions
Abstract: In this study, we investigated uniform and non-uniform damped and time-dependent elastic beams resting on bi-parametric foundation subjected to harmonically varying moving load. The beam properties, including moment of inertia and mass per unit length, were assumed to be either constant or varying with position along the beam span in this study. The solution methods were based on Mindlin-Goodman method, Fourier sine transformation, weighted residual method, integral transformation, and theory …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 4, Issue 1, 2026 · pp. 33–50 Read article
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Medicinal Properties of Oxytenanthera abyssinica: A Narrative Review
Abstract: Oxytenanthera abyssinica, a plant local to the African landmass, has gotten a parcel of intrigued in later a long time for its conceivable restorative benefits; it has been utilized in conventional medication for decades since of its assumed mending capabilities. In spite of its long history, careful logical examination into its restorative potential is being attempted. This review paper explore into the multidimensional part of O. Abyssinica is in progressed …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
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Experimental Analysis of Cutting Forces Under Different Machining Parameters and Carbide Inserts During Turning of Hardened AISI 4340 Steel
Abstract: Turning of hardened materials with an advanced coated carbide insert has numerous advantages over the grinding process, e.g., reduced process cost, high material removal rate, and less environmental concern due to the elimination of the cutting fluid. Process parameters in conventional machining operations like cutting speed, feed, and depth of cut play the most crucial role behind the generation of heat which also leads to microstructural changes, improved tool life, …
Published in Journal of Polymer & Composites Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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A Review on Nutritional Benefits of the Black Tea
Abstract: Black tea, a cornerstone of global beverage culture, boasts a fascinating history and captivating journey from plant to cup. Derived from the Camellia sinensis plant, black tea distinguishes itself from its green tea cousin through a unique processing method. Unlike green tea, which undergoes minimal processing to preserve its fresh character, black tea undergoes full fermentation. This controlled oxidation process unlocks a deeper layer of flavor and aroma, resulting in …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 1, 2024 · pp. 21–27 Read article
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Comparative Assessment of Antibacterial Effectiveness, Bioactivity, Fluoride Release, and Microleakage of Various Bioactive Smart Composites: An In Vitro Investigation.
Abstract: The demand for dental composites with enhanced properties has led to the development of bioactive smart composites aimed at addressing multiple aspects of restorative dentistry. This in vitro investigation aimed to conduct a comparative assessment of the antibacterial effectiveness, bioactivity, fluoride release, and microleakage properties of various bioactive smart composites. Bioactive smart composites are emerging dental materials designed to promote remineralization and inhibit bacterial growth, thereby enhancing the longevity of …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 76–86 Read article
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Comprehensive Analysis of MRSA Peptides Via Maldi
Abstract: The present study employed Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry to analyze methicillin-resistant Staphylococcus aureus peptides, focusing on various parameters associated with mass-to-charge (m/z) values. Through systematic data collection and analysis, including time, intensity, signal-to-noise ratios, quality factors, resolutions, areas under the peaks, relative intensities, full widths at half maximum, Chi-squared values, and background peaks, comprehensive insights into the spectral characteristics of methicillin-resistant Staphylococcus aureus peptides were obtained. Methicillin-resistant Staphylococcus …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 98–101 Read article
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The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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Experimental Investigation of Aluminum Alloy 8010 by Friction Stir Welding
Abstract: A solid state welding method called friction stir welding (FSW) is used to fuse metals and alloys that are challenging to fuse using traditional fusion welding. The effects of tool pin and shoulder diameter on joining the aluminum alloy Al 8010 were examined in this study. The basis material for combining single butt-welded joints is a plate with a thickness of 6 mm. The welding was carried out on the …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 3, 2024 · pp. 14–19 Read article
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Computation of the Necking in Bars Without Geometrical Imperfection
Abstract: This paper presents a finite element analysis to compute the neck profiles of smooth, circular cylindrical bars in shear-free grip under uniaxial tensile load. The analysis uses 4-node quadrilateral element with linear displacement variation, as well as 8-node Serendipity quadrilateral element with curved sides and a quadratic variation of the displacement field, for power law hardening materials that follow von Mises plasticity. All the elements are based on isoparametric formulation. …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 2, 2024 · pp. 10–19 Read article