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238 articles for “microbial”
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Application of Monod and Finite Element Models for Groundwater Cleanup in the Niger Delta Area of Nigeria
Abstract: The Niger Delta region of Nigeria, known for its rich biodiversity and extensive oil and gas exploration activities, faces significant environmental degradation, including groundwater contamination. This study investigates the application of Monod kinetics and Finite Element Models (FEM) in the cleanup of groundwater contamination in the Niger Delta. Specifically, the research integrates Monod models to understand microbial degradation rates in contaminated aquifers and FEM to simulate the groundwater flow and …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 1, 2025 · pp. 39–47 Read article
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A Comprehensive Review on Pharmacological and Therapeutic Uses of Azadirachta Indica in the Treatment of Various Diseases
Abstract: In ancient medicine, the majority of illnesses were treated with plants and phyto-compounds. The most beneficial traditional medicinal plant is Azadirachta indica (Neem). In Ayurveda, it has several therapeutic effects. One of the most adaptable medicinal herbs, it exhibits a broad range of biological action. It possesses medicinal qualities, including anti-microbial, and high efficacy and safety agents. The biologically active components of this plant have a wide range of uses. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 14–25 Read article
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Mind-Gut Connection: The Psychosomatic Effects of Stress and Emotions on Digestive System
Abstract: Stress, understood as an immediate disruption to bodily equilibrium, triggers an adaptive or allostatic response that impacts gastrointestinal function both in the short and long term. The enteric nervous system communicates in both directions with the brain through parasympathetic and sympathetic pathways, collectively forming what is known as the brain-gut axis. Unani scholars describe stress as a response to the loss of something valuable, such as an opportunity, a desired …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 11–14 Read article
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Evaluation of Raw Cow Milk Preservation Using Extracted Mango Seed Kernels and Rosemary Leaves Powder, Ethiopia
Abstract: The study aimed to evaluate the raw cow milk preservation using extracted mango seed kernels and rosemary leaves powder. Fresh cow milk samples collected aseptically from Debre Birhan University farm. The fresh cow milk treated at different concentrations (0.5, 1.0 and 1.5%) of ethanol extract of mango seed kernel, rosemary leaves and equal mix of both extracts with 100 ml of milk then store at room temperature. Mango seed kernels …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 20–28 Read article
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The Role of Soil Quality Parameters in Enhancing Agricultural Productivity
Abstract: Thus one can define soil quality as a set of physical, chemical and biological properties of the surface layer of the Earth’s crust that affects agriculture production. In this study, some of the factors which are related to soil quality include pH, texture, organic matter content, nutrient availability and microbial activity that affect crop germination as well as yield. It looks at the way in which the soil factors influence …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 3, 2025 · pp. 48–66 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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Bioremediation of Crude Oil-Contaminated Loamy Soil Using Plantain (Musa Paradisiaca) Stem Waste as a Biostimulant
Abstract: Crude oil contamination of soil is a pressing environmental challenge in oil-producing regions, especially in the Niger Delta of Nigeria. It degrades soil fertility, disrupts microbial ecosystems, and poses long-term ecological and health risks. Traditional remediation methods are often cost- prohibitive and environmentally intrusive, prompting the search for sustainable alternatives. This study investigates the potential of plantain (Musa paradisiaca) stem waste – a readily available agricultural byproduct – as a …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 1, 2026 · pp. 1–11 Read article
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Monoclonal Antibodies in Next Generation Animal Nutrition: Mapping Nutrient Immune Interaction Networks in Livestock Systems
Abstract: Sustainable livestock production is increasingly constrained by disease pressure, antimicrobial resistance, and declining feed efficiency under intensifying environmental stressors. Conventional nutritional strategies, while essential, remain insufficient to precisely regulate immune function and metabolic resilience. This review explores the emerging role of Monoclonal antibodies as advanced biologics in next generation animal nutrition, with a focus on mapping nutrient immune interaction networks in livestock systems. It synthesizes current knowledge on how nutrients …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Investigation of Pollution Status in River No. 2, Freetown, Sierra Leone, Using Physicochemical and Bacterial Indicators
Abstract: This study assessed the physicochemical and bacteriological quality of surface water in the River No. 2 watershed, Sierra Leone, through monthly sampling from March–August 2024 at upstream, midstream, and downstream sites. Analyses included temperature, turbidity, pH, electrical conductivity, total dissolved solids, ammonia, fluoride, sulfite, nitrate, lead, arsenic, chromium, and microbial indicators (Escherichia coli, fecal and non-fecal coliforms). Most physicochemical parameters met WHO drinking-water guidelines. pH (7.0–7.3), TDS (7–17 mg/L), turbidity …
Published in International Journal of Pollution: Prevention & Control · Vol. 4, Issue 1, 2026 · pp. 11–27 Read article
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Upgrading Nutritive Value of Rice Straw: Processing, Supplementation, and Agronomic Innovations for Improved Utilization
Abstract: Rice straw, a major byproduct of rice production, holds significant potential as a livestock feed but is constrained by its high lignocellulosic content, low crude protein, and poor digestibility. Enhancing its nutritive value is imperative for sustainable livestock production. This study explores a range of innovative strategies aimed at improving rice straw’s digestibility and overall nutritional quality. Physical processing techniques, including chopping, grinding, soaking, and steam treatment, enhance its surface …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 1, 2026 · pp. 42–58 Read article
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The Burden of Empirical Therapy: Analyzing the Predominance of Broad-Spectrum Antibiotic Usage in Lower Respiratory Tract Infections
Abstract: Lower respiratory tract infections (LRTIs) remain one of the leading causes of morbidity and hospitalization worldwide, particularly among older adults, immunocompromised individuals, and patients with chronic respiratory disorders. These infections include conditions such as community-acquired pneumonia, hospital-acquired pneumonia, bronchitis, and acute infective exacerbations of chronic lung disease, all of which often require rapid clinical intervention. Because microbiological confirmation of the causative pathogen frequently takes 48–72 hours, clinicians generally initiate empirical …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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Lysogenic Phage Cocktails with Embedded Fluorophores for Field Wound Diagnostics.
Abstract: Rapid and accurate detection of wound infections in field settings remains a critical challenge in emergency and military medicine. Conventional microbiological diagnostics are time- consuming and laboratory-dependent. Bacteriophages, particularly lysogenic phages, offer high specificity toward bacterial hosts and can be engineered as diagnostic tools. A translational framework was developed for lysogenic bacteriophage cocktails embedded with fluorophore reporters for rapid, point-of-care wound diagnostics. Mechanisms of phage infection, lysogenic integration, and fluorophore …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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MAP: The Invisible Shield Protecting Our Product's Journey
Abstract: Modified Atmosphere Packaging (MAP) has established itself as one of the most reliable and widely adopted preservation technologies in the modern food industry, offering a practical means of extending shelf life while maintaining the sensory and nutritional integrity of food products throughout storage and distribution. The fundamental working principle revolves around deliberately altering the gaseous composition within sealed packages, primarily through the strategic use of carbon dioxide, nitrogen and oxygen …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 52–58 Read article
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Diet-Driven Enhancement of Immune Resilience, Disease Resistance, and Performance: Mechanistic Insights, Nutritional Interventions, and Implications for Sustainable Dairy Development
Abstract: This review synthesizes current knowledge on how dietary strategies can strengthen immune resilience, improve disease resistance, and enhance productive performance in dairy systems while advancing sustainable development. Immune function in dairy cattle is profoundly influenced by nutrition, with energy, protein, essential amino acids, fatty acids, vitamins, minerals, and bioactive compounds playing critical roles in shaping both innate and adaptive immune responses. Suboptimal nutrition impairs immune competence, increases susceptibility to infectious …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 15–24 Read article
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Advancements and Challenges of Modern Breeding over Conventional Breeding
Abstract: Plant breeding dates back thousands of years, when people first deliberately bred plants based on visually pleasing characteristics. The domestication of wild plants aided this process, resulting in the evolution of numerous breeding strategies over time. Conventional breeding, which is distinguished by selective breeding based on superior performance, used procedures such as pure-line selections, mass selection, backcross breeding, recurrent selection, and hybridization. While effective, classical breeding procedures were time-consuming and …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–5 Read article
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POTENTIAL BIOPRESERVATIVE EFFECT OF ANTIMICROBIAL PEPTIDES OF SEEDS OF Vigna unguiculata (Cow Pea) ON Hibiscus sabdariffa L. (Roselle) Calyces (Zobo) DRINK
Abstract: Natural and efficient food preservatives are in greater demand because of growing concerns about the safety and quality of processed beverages. Antimicrobial peptides have emerged as promising natural substitutes for synthetic preservatives, boasting advantages like wide-ranging activity and reduced toxicity. In this research, we investigate the inhibitory effects of these peptides against common spoilage microorganisms in 'Zobo' drink. Peptides were extracted and purified from germinated Vigna unguiculata) seeds harvested on …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 1, 2025 · pp. 26–41 Read article
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A Review on Phytochemical and Pharmacological Properties of Anacyclus Pyrethrum (Akarkara)
Abstract: The wild species Anacyclus pyrethrum, or A. pyrethrum, is a member of the Asteraceae family. It is commonly known as Akarkara. It originated in Spain, Morocco, and Algeria, and has since spread to Sri Lanka, India, Ukraine, Germany, Myanmar, France, and Poland. It is the benefits of bioactive compounds of plant found the chemical makeup, analgesic, anti-inflammatory, and wound-healing effects of hydroalcoholic extracts of A. pyrethrum’s roots, seeds, leaves, and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 102–110 Read article