Search
310 articles for “active targeting”
-
Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
-
Molecular Docking Studies of Moringa concanensis Nimmo Leaf Phytocompounds for Brain Cancer
Abstract: Phytochemicals are the secondary metabolites of medicinal plants and are considerably used in traditional cancer research. Computational methods involving virtual screening, shape and pharmacophore analysis and molecular docking have been used to select chemicals that target a particular protein or enzyme and to determine potential protein targets for well characterized as well as for novel phytocompounds. Objective of the present study is, in silico approach to identifying the anticancer activity …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 8, Issue 1, 2018 · pp. 26–34 Read article
-
Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
-
A Study on Challenges and Obstacles for Women in Adaption of Ecommerce Technologies: State of the Art
Abstract: AbstractWhen we talk of national development, it goes without saying that the role of women is immense. Since the Eighth Five Year Plan which focused on empowering women, specifically at the grass-root level, we have come a long way. But there is still a long way to go. It’s quite an oxymoron that while women are critical partners they do not enjoy an equal status in the society. Any society …
Published in E-Commerce for Future & Trends · Vol. 5, Issue 3, 2018 · pp. 7–14 Read article
-
HERB BASED NANO-FORMULATIONS USED AS ANTI-INFLAMMATORY ACTIVITY
Abstract: It plays a crucial role in the progression of various ailments such as gastric inflammation, atherosclerosis, rheumatoid arthritis, asthma, and cancer.The lack of antibodies and transporters leads to the need to create molecules for the treatment of inflammatory diseases. Nanometer technology has become an exciting area of research over the past decade as its performance outperforms many of its products. This article discusses the green synthesis of zinc oxide nanoparticles …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 1, 2023 · pp. 42–52 Read article
-
Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
-
Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
-
Structural, Optical, Surface, and Gas-Sensing Properties of rGO/Sn1–xZnxO₂ Nanocomposites
Abstract: rGO/Sn₁–ₓZnₓO₂ nanocomposites with x = 0.00–0.75 were synthesized by sol–gel auto-combustion followed by wet impregnation with reduced graphene oxide. The adopted synthesis route enabled homogeneous Zn incorporation into the SnO₂ matrix and uniform distribution of rGO, leading to improved structural integrity and interfacial contact between the two components. XRD confirmed a dominant tetragonal cassiterite SnO₂ structure, while FTIR, FESEM, EDS, UV–visible, and BET analyses verified oxide–rGO coupling, Zn-dependent structural modification, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 429–452 Read article
-
In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
-
Current Drugs Target the EGFR
Abstract: Cancer is a devastating disease, but there have recently been significant advancements in therapy that have identified EGFR and its related proteins as valuable indicators and targets for treatment. The ERBB receptor tyrosine kinase superfamily includes EGFR, which is a transmembrane glycoprotein. When the EGFR receptor interacts to its particular ligand, EGF, it causes tyrosine residues to be phosphorylated and forms receptor dimers with other members of the receptor family. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 1–8 Read article
-
Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 62–73 Read article
-
Strategies in the Delivery of Nonsteroidal Antiinflammatory Drugs
Abstract: Non-steroidal anti-inflammatory drugs [NSAIDs]. are widely used for the management of pain, inflammation, and fever. However, their effectiveness is often limited by gastrointestinal side effects such as ulceration and bleeding, as well as systemic complications including renal toxicity and cardiovascular risks. To address these challenges, various strategies have been developed to improve the delivery of NSAIDs, aiming to enhance their therapeutic efficacy while minimizing adverse effects. This abstract provides an …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 44–61 Read article
-
Exploring the Connection: Analyzing the Relationship Between Duqu and Stuxnet
Abstract: Malware computer worms like Stuxnet and Duqu have the ability to take down any computer system in the globe. Although they are extremely similar to one another, Duqu is superior to Stuxnet. Because it comes in two versions, Duqu 1.0 and 2.0, it is also more harmful and dangerous than Stuxnet. The first malware attack to garner international attention was Stuxnet, which was designed to physically harm industrial infrastructure that …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 3, 2024 · pp. 11–17 Read article
-
A Concise Overview of Recent Developments and Uses in Nano-Silica and Nanoparticles Encased in Silica
Abstract: Nano-silica and silica-coated nanoparticles have gained significant attention lately due to their exceptional chemical and physical properties, including a high surface area-to-volume ratio, adjustable porosity, thermal and chemical stability, biocompatibility, and ease of surface modification. These characteristics make them versatile materials applicable in various scientific and industrial sectors. Their ability to control particle size, shape, and surface traits allows them to be effectively utilized in catalysis, drug delivery, biosensing, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 696–704 Read article
-
A multi-index remote sensing analysis for Characterizing water stress, and environmental indicators in Girnar Wildlife Sanctuary, Gujarat, India
Abstract: Water scarcity is a critical concern in arid and semi-arid regions, with implications for ecological stability, public health, and sustainable resource management. The Girnar Wildlife Sanctuary, Gujarat, presents a case where ecological fragility intersects with cultural and religious pressures. This study employs satellite remote sensing and GIS-based approach to characterize water stress parameters within the sanctuary. Key spectral indices along with Land Use and Land Cover (LULC) were integrated through …
Published in Journal of Remote Sensing & GIS · Vol. 17, Issue 1, 2026 · pp. 1–11 Read article
-
Interaction of Cardiotoxin with Calmodulin and its EF Hand Peptides
Abstract: Calmodulin is a ubiquitous protein having EF hand peptide(helix-loop-helix sstructural domain), which is found in all the eukaryotic cells. Calmodulin functions as a multipurpose intracellular receptor, mediating much calcium regulated processes and undergoes conformational change upon binding to calcium. These activated calmodul in then bind to a number of different target proteins, including a family of calcium/calmodul in-dependent protein kinases which then phosphorylatedserine’s or threnodies on other proteins. Cardiotoxin, snake …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 9–13 Read article
-
An Evaluation of Letrozole and Clomiphene Citrate Efficacy as Ovulation Induction Medication in Females with Polycystic Ovarian Condition
Abstract: Polycystic ovarian condition is the most common endocrinopathy in anovulatory infertile females. As a long-established conventional treatment for ovulation induction, clomifene citrate (also known as clomiphene) is still recommended to PCOS patients as their first line of treatment. Indian PCOS women are more prone to have high levels of clomiphene resistance due to the high frequency of insulin resistance . While letrozole has a high potential for ovulation induction, it …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 2, 2024 · pp. 23–29 Read article
-
3D Printing for Polymer Science Visualization
Abstract: The burgeoning field of 3D printing offers exciting possibilities for various scientific disciplines. This paper explores the potential integration of 3D printing technology within the realm of polymer analysis. While the core focus of memory forensics investigations lies in digital forensics, the concept of 3D printing complex data structures presents intriguing possibilities for the visualization and communication of findings in polymer science. Here, we propose a future research avenue where …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 96–101 Read article
-
CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
-
Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 42–49 Read article