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75 articles for “acetone”
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Synthesis and Chemical Characterization of Benzopyran Derivatives Fused to Pyrimidine Moiety
Abstract: In an attempt to find a new class of antimicrobial agents, a series of fused benzopyran derivatives containing pyrimidine moiety were prepared via the reaction of 2-(1h-benzo[d] imidazol-2-yl acetonitrile with 2-amino-3-(1h-benzo[d] imidazol-2-yl)-4-phenyl-4h-chromen-7-ol in the presence of piperidine and anhydrous zinc chloride. The target molecules were also synthesized using interchange component strategy. These compounds were screened for their antibacterial activity against gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gram-negative bacteria (Pseudomonas …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 11–23 Read article
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Preparation and Characterization of Fenofibrate Freeze-Dried Crystals
Abstract: The present research work was aimed to prepare fenofibrate freeze-dried crystals using poloxamer by freeze-drying technique. Fenofibrate crystals containing poloxamer were prepared by freeze drying using acetone and water as solvent system. The prepared formulations containing drug and poloxamer were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared freeze-dried crystals was compared with its physical mixture …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 16–22 Read article
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Development and Validation of RP-HPLC Method for Determination of Thermal Degradation Impurity in Macrolide Immunosuppressant Substance and Drug Product
Abstract: The present study describes a simple and stability-indicating reverse phase high-performance liquid chromatography (RP-HPLC) method for the quantification of the thermal degradation impurities of Tacrolimus (FK506) namely Ally ester rearrangement impurity (Impurity R) in Tacrolimus capsules and drug substances. Successful separation of impurity R from Tacrolimus, its other related substances and its tautomers were achieved on a Zorbax XDB C8 (150×4.6 mm, 5 μm) and detector of UV at 210 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 14–19 Read article
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Formulation and Evaluation of Microencapsulated Levofloxacin Gel
Abstract: To treat various buccal infectious diseases, a sustained release microencapsulated levofloxacin gel was formulated. Levofloxacin microspheres were being prepared following o/w emulsion solvent evaporation technique by varying concentrations of ethyl acetate, ethyl cellulose and tween 80. Depending on their flow properties almost all the microspheres were found to be excellent. The drug-excipient compatibility study carried out using Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) resulted that the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 39–47 Read article
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Validation and Forced Degradation Studies for the Determination of Erlotinib in Bulk and Pharmaceutical Dosage Forms by RP-HPLC
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle size) in isocratic mode, using mobile phase composition of 0.1% orthophosphoric acid: Acetonitrile in the ratio of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 2, 2016 · pp. 44–53 Read article
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Development of Validated Stability Indicating RP-HPLC Method for Amisulpride Injection
Abstract: Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast RPHPLC method for the analysis of Amisulpride injection. A Waters HPLC system with Octacysilane 150 mm × 4.6 mm column is employed for the analysis using pH 4.5 phosphate buffer solution, acetonitrile and methanol in the ratio of (75:20:5 v/v) as mobile phase. Signal from Amisulpride is detected at 280 nm by UV …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 24–40 Read article
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A New RP-HPLC Method for Simultaneous Estimation of Atorvastatin and Fenofibrate in Its Bulk and Tablet Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Atorvastatin and Fenofibrate by RP-HPLC method. Methods: Chromatographic separations were carried using Phenomenex C18 column (4.6 × 250 mm, 5 µm) column with a mobile phase composition of 0.1 M Ammonium acetate:acetonitrile (60:40) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto sampler, separation module 2695 with PDA detector at …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 12–18 Read article
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A Novel Analytical Method for the Simultaneous Estimation of Remogliflozin and Metformin Hydrochloride
Abstract: Specific and novel strategy has been improved for assessment of Remogliflozin and Metformin hydrochloride in mass and plan and cleaning tests by UPLC-PDA. The scientific method was the phosphate Buffer (pH: 4.5): Acetonitrile, (60:40%, v/v) utilizing the spherisorb C18, 5 µm, 4.6 mm×150 mm insightful segment with investigation season of 5 min. The progression of versatile stage through section was 1.0 ml/min. The test volume was 10 µl. The discovery …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 3, 2020 · pp. 1–15 Read article
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Phytochemical Screening and Structural Elucidation of Extracts from Garcinia kola (Heckel) Seeds
Abstract: This study evaluated the bioactive components of G. kola seeds extract to further establish its medicinal potentials. Extracts were obtained using different solvents thus; ethanol, methanol, ethyl acetate, acetone, cold and hot water. Phytochemical (quantitative) screening showed that saponins, flavonoids, terpenoids, tanins, glycoside and alkaloids are present in the G. kola extracts: however, the quantities vary with regards to the extraction solvent used. The highest quantity of phenols (35.63±0.06 mg/g) …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 7, Issue 2, 2020 · pp. 23–27 Read article
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Determination of the Antidiabetic Drug Miglitol in Pharmaceuticals by Ultra-Performance Liquid Chromatography
Abstract: Miglitol (MGL) is a drug used in the treatment of type-2 diabetes mellitus. A new analytical method employing ultra-performance liquid chromatography (UPLC) with UV-detection is presented for the determination of MGL in bulk drug and tablet forms. Analysis was performed in less than 3 min in isocratic mode on a reversed phase BEH C18 (100 mm × 2.1 mm; 1.7 µm particle size) column using phosphate buffer of pH 3.7-acetonitrile …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 11–26 Read article
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Isolation, Phytochemical Investigation and Biological Screening of Roots of Cosmos Sulphureus
Abstract: Aims and objectives: The plants are integral part of traditional system of medicine. Cosmos is one such medicinal plant traditionally being used in Brazil and Mexico for treatment of several diseases. The present study is aimed to evaluate the properties of Cosmos sulphureus and its preliminary phytochemical screening, extraction, purification and identification of active components.Materials and Methods:All roots were handpicked and washed with tap water. Cleaned roots were air dried …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 10, Issue 1, 2023 · pp. 1–9 Read article
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Development and Validation of Liquid Chromatography-Tandem Mass Spectrometric Method for Assay of Zidovudine in Human UrineDevelopment and Validation of Liquid Chromatography-Tandem Mass Spectrometric Method for Assay of Zidovudine in Human Urine
Abstract: A sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS-MS) method was developed to determine zidovudine (ZDV) in human urine. After solid-phase extraction with SPE cartridge, the urine sample was analyzed on a C18 column (Symmetry 3.5 µm; 75×4.6 mm i.d) interfaced with a triple quadrupole tandem mass spectrometer. Positive electrospray ionization was employed as the ionization source. The mobile phase consisted of water-acetonitrile (20:80, v/v).The method was linear over a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 3, 2014 · pp. 17–23 Read article
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Quantitative Determination of Isomeric Components of essential oils by RP-HPLC-PDA in multi-herbal tablets
Abstract: Essential oils are lipophilic and highly volatile secondary plant metabolites, principally mono- and sesquiterpenes. The widespread usage and applications in biopharmaceutics and cosmoceutics of these components drives their quality assessments criteria to be established. Gas chromatography is one of the predominantly used technique for analyzing volatile oils. Although Gas Chromatography employs estimation designs operated at elevated temperatures leading for plausible structural alterations of thermo labile compounds. Hence, a novel gradient …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 19–28 Read article
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New RP-HPLC Method Development and Validation for Simultanious Estimation and Forced Degradation Studies of Gallic acid and Curcumin in Solid Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 7–15 Read article
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Analysis of Anti-psychotic Drug Penfluridol in Human Plasma by HPLC and MS/MS
Abstract: Penfluridol is a new long-acting neuroleptic drug known to be used widely for treating psychotic conditions. An internal standard was employed, which was penfluridol D7 (IS). The analyte and the IS were separated on a Phenomenex Kinetex C18, 5µm 100A, 100*4.6mm column using acetonitrile (40:60, v/v) as the mobile phase and 5 mM ammonium formate as the stationary phase. The retention time of Penfluridol and Penfluridol d7 was set at …
Published in Trends in Drug Delivery · Vol. 9, Issue 2, 2022 · pp. 36–45 Read article