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78 articles for “Safety Profile”
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Multi-Sensor System for Underwater Pothole Detection to Enhance Road Safety During Monsoon Seasons
Abstract: Monsoon seasons across India and similar tropical regions severely compromise road safety by causing water accumulation that conceals dangerous potholes beneath stagnant pools, leading to frequent vehicle damage, tire punctures, and fatal accidents. Traditional detection methods relying on smartphone accelerometers, ultrasonic sensors, or machine vision fail under flooded conditions due to acoustic signal reflection at water surfaces and optical distortions from glare and turbidity. This research proposes an innovative multi-sensor …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 4, Issue 1, 2026 · pp. 25–32 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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The Impact of Nanotechnology in Transforming Neuro-oncology - A Comprehensive Review
Abstract: The treatment of central nervous system (CNS) tumours, including aggressive malignancies like glioblastoma, faces significant challenges. The blood–brain barrier (BBB) blocks nearly 98% of small-molecule drugs from achieving therapeutic levels in the brain, and the heterogeneity of these tumours frequently contributes to treatment resistance and poor outcomes. Traditional approaches, including chemotherapy and radiotherapy, are hindered by systemic toxicity and inadequate drug penetration. Nanotechnology provides a promising alternative, as nanoparticles (NPs) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 627–637 Read article
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Comparative Study of Uniform and Non-Uniform Beams Resting on Bi-Parametric Foundation Under Harmonic Load with Time Dependent Boundary Conditions
Abstract: In this study, we investigated uniform and non-uniform damped and time-dependent elastic beams resting on bi-parametric foundation subjected to harmonically varying moving load. The beam properties, including moment of inertia and mass per unit length, were assumed to be either constant or varying with position along the beam span in this study. The solution methods were based on Mindlin-Goodman method, Fourier sine transformation, weighted residual method, integral transformation, and theory …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 4, Issue 1, 2026 · pp. 33–50 Read article
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Analysis of Simply Supported and Clamped-Clamped Beam Resting on a Pasternak Foundation Subjected to Moving Load with a Damping Term
Abstract: A comparative analysis of simply supported and clamped-clamped Bernoulli-Euler beams resting on a Pasternak foundation under the action of a concentrated moving load with a damping term, when the inertia effect of the moving load is considered in its analysis, was investigated in this study. The governing equation was solved by representing the Dirac delta function through a Fourier cosine series and applying a combination of analytical techniques, including the …
Published in Journal of Experimental & Applied Mechanics · Vol. 16, Issue 3, 2025 · pp. 42–59 Read article
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Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes
Abstract: Dental caries remains a prevalent oral health concern worldwide, prompting ongoing research into innovative approaches for caries prevention and management. This experimental investigation endeavors to conduct a comparative assessment of the bioactivity, fluoride release kinetics, shear bond strength, and compressive strength of glass ionomer cement (GIC) augmented with three distinct types of inorganic bioactive nanoparticles. Bioactive nanoparticles have garnered interest in dental materials for their potential to enhance material properties …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 292–303 Read article
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An in-silico toxicity study of the phytocompounds found in Pongamia pinnata leaves using the ProTox-II web server
Abstract: The aim of the current study was to determine the Insilco toxicity of the phytocompound present in the leaves of Pongamia pinnata. The leaves of Pongamia pinnata have long been used in traditional medicine for their therapeutic properties. Nowadays, herbal toxicity is a common problem caused by incorrect dosage. The FDA reviews the safety and effectiveness of herbal products only in response to patient or health care provider complaints—problems with …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 Read article
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Multiphysics Simulation and Thermal Characterization of VVER-1200 Steam Generator for Optimized Heat Transfer and Structural Integrity
Abstract: VVER-1200 is a Russian design reactor which consist of Two circuits comprising reactor core, piping, vertical steam generator, pressurizer, active and passive safety systems, turbine and generator. This reactor involves single phase flow from reactor core to steam generator (SG) where high pressurized water exchanges heat with normal water resulting in steam production. The flow is turbulent, which enables maximum efficiency to heat transfer. Using ANSYS Workbench's multi-physics simulation capabilities, …
Published in Journal of Thermal Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 7–15 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Biomedical Approach to Developing and Characterizing Chitosan Nanoparticles Encapsulating Urapidil for Hypertension Management
Abstract: The aim of this study was to create Chitosan Nanoparticles loaded with Urapidil to achieve controlled drug release, enhance solubility, and reduce dosing frequency to improve patient adherence to therapy for hypertension. Urapidil was formulated into nanoparticles via the ionic-gelation method using Chitosan as a polymer, Sodium tripolyphosphate as a cross-linking agent, and filled into hard gelatin capsules after lyophilization. Pre-formulation studies, including melting point analysis and determination of the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 43–51 Read article
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Solanum viarum Dunal: Ethnomedicinal Importance, Phytochemical Profile and Pharmacological Potential — A Comprehensive Review
Abstract: Solanum viarum Dunal, commonly known as tropical soda apple or Sodom apple, is a medicinally important plant belonging to the family Solanaceae. The plant has been widely utilized in traditional medicine systems for the treatment of fever, cough, skin disorders, inflammation, gastrointestinal ailments, and microbial infections. The present review comprehensively summarizes the ethnomedicinal importance, phytochemical profile, pharmacological activities, and pharmaceutical significance of S. viarum. Literature reports indicate that the plant …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 3, 2026 Read article
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article
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Nutritional Enhancements in Dairy Products
Abstract: Dairy products play a crucial role in diets globally, providing key nutrients like proteins, fats, vitamins, and minerals. However, with evolving dietary needs and a growing focus on public health, the fortification of dairy products has emerged as a critical strategy to enhance their nutritional profile. This review explores the fortification of dairy products with vitamins, minerals, probiotics, and other health-promoting ingredients, examining the methods, benefits, challenges, and future prospects …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 2, 2024 · pp. 18–23 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Multimodal Data Fusion with Hybrid Machine Learning for Enhanced Prediction of Li-Ion Battery Remaining Useful Life and State of Charge
Abstract: Lithium-ion battery materials used in modern energy storage systems are required to exhibit high reliability, safety, and long lifecycle performance under varying operational and environmental conditions. Accurate prediction of Remaining Useful Life (RUL) and State of Charge (SoC) is therefore essential for understanding material degradation behavior, improving manufacturing quality, and enabling effective lifecycle management. However, nonlinear electrochemical aging, load variability, and thermal uncertainty significantly complicate accurate estimation of these parameters. …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 4, Issue 1, 2026 · pp. 1–5 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Design and Validation of an Artificial Intelligence-Driven Digital Twin for Real-Time Monitoring and Control in Polymer Composite Manufacturing
Abstract: Polymer Matrix Composites (PMCs) have become indispensable in high-performance sectors such as aerospace and automotive engineering, offering exceptional strength-to-weight ratios that outperform traditional metals in many demanding applications. However, the reliability of manufacturing PMCs via Vacuum-Assisted Resin Transfer Molding (VARTM) is frequently undermined by stochastic process variabilities. Unpredictable fluctuations in thermal history, preform permeability, resin rheology, and ambient conditions often lead to some defects; namely voids, dry spots, and incomplete …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 224–233 Read article