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485 articles for “Mechanism” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Mechanically Operated Portable Hydrotesting Setup
Abstract: Hydrostatic testing is a crucial process in ensuring the integrity and safety of pressure vessels, pipelines, and various other industrial equipment. Traditional hydrostatic testing setups often require significant infrastructure and resources, limiting their accessibility and flexibility, especially in remote or constrained environments. This research paper presents the design, development, and implementation of a portable hydro testing setup tailored to address these challenges. The proposed setup offers a compact, versatile, and …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 2, Issue 1, 2024 · pp. 21–27 Read article
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A Quasi-Experimental Investigation of The Effects of Two Different Negative Pressure Levels During Open Endotracheal Tube Suctioning on Physiological Parameters in Mechanically Ventilated Patients in The PCCM ICU At Pt. B.D. Sharma P.G.I.M.S., Rohtak
Abstract: Introduction: Patients who are intubated often have difficulty clearing secretions through coughing. As a result, endotracheal suctioning is essential to minimize the risk of consolidation and atelectasis, which could impair ventilation. However, suctioning can pose several risks and complications, including bleeding, infection, atelectasis, hypoxemia, cardiovascular instability, increased intracranial pressure, and potential damage to the tracheal mucosa. The level of negative pressure applied during suctioning plays a crucial role in the …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 29–58 Read article
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AI-Driven Psychological Profiling on Social Media: Mechanisms, Ethical Breaches, and Regulatory Challenges in Data Inference
Abstract: This literature review examines AI-driven psychological profiling on social media, analyzing 21 academic studies that focus on machine learning techniques such as supervised learning, deep neural networks, sentiment analysis, and natural language processing. These methodologies infer mental health indicators—such as depression, anxiety, and stress—from users' digital footprints, encompassing linguistic patterns, engagement metrics, and temporal behaviors. While these tools offer potential for early detection of psychological distress, they also raise significant …
Published in Recent Trends in Social Studies · Vol. 2, Issue 1, 2025 · pp. 1–7 Read article
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Antibiotic Resistance in Microbes: History, Mechanisms, Therapeutic Approaches, and Strategies for Mitigation
Abstract: The global emergence of clinically significant antibiotic resistance is increasingly linked to the environment. Antimicrobials, metals, and biocides are just a few of the substances that are released into the environment through paths that are regulated by environmental regulators. Consequently, environmental regulators ought to be heavily involved in developing national and international antimicrobial resistance (AMR) measures. Antimicrobial compounds from pharmaceutical waste, agricultural runoff, and wastewater discharge contribute to the spread …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–11 Read article
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Effect of Process Variables on the Mechanical Characteristics of form Fabricated Materials
Abstract: Additive manufacturing prominent rapidly advancing technologies for producing 3D-printed products. Initially developed by stratasys, FDM technology emerged during the 1980s. This additive manufacturing technique builds products by extruding semi-molten material through a nozzle onto a platform. PLA and ABS are among numerous thermoplastics that are commonly used as filaments in this procedure. Purpose of research was to observe the effect of variables such as infill percentage, bed temperature, printing speed …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 3, Issue 2, 2025 · pp. 32–39 Read article
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Fabrication and Multi scale Characterization of Functionally Graded Composites Reinforced with Hybrid Ceramic–Metallic Phases
Abstract: Using composite materials as functionally graded composites (FGM) can improve its excellent material properties. In this work, magnesium peroxide, silicon carbide, and aluminum are used to create four-layer FGMs. The sintering process, which blends the particles of each material using a powder methodology, has been used to complete the fabrication process. Three factors, including sintering time, sintering temperature, and compacting pressure, are taken into account when fabricating FGM. The FGM …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 1–11 Read article
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Drug Induced Immune Mediated Nephritis: Molecular Mechanism , Pathways and Clinical Implications
Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article
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Investigating mosquito innate immune defence mechanism towards malaria vaccine development
Abstract: Mosquito-borne diseases weigh heavily on public health across the globe. The mosquito’s innate immune system certainly decides whether malaria parasites survive inside the vector, and that sighted it as a logical place to discover new vaccine ideas. In this review, we examine how Anopheles mosquitoes defend themselves against Plasmodium parasites and how those defenses could be turned into tools for malaria control. We focus on three layers of immunity: antimicrobial …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 50–54 Read article
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The Global and Regional Challenge of Pan-Antibiotic Resistance: A Review of Emerging Threats and Mechanisms
Abstract: Antimicrobial resistance (AMR) is one of the major and most intricate threats to the health of the 21st century as it is core to the undermined expertise of the common clinical practice and public health security worldwide. The problem is characterized by the extensive development of bacterial pathogens into extremely drug-resistant (XDR) and pan-drug-resistant (PDR) so- called superbugs faster than it can be done with therapeutics. It is a synthesis …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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Structure–Property Correlation of Infill Topology and Density on Tensile and Flexural Performance of FDM-Printed PLA and ABS
Abstract: Additive Manufacturing (AM), particularly Fused Deposition Modeling (FDM), has become a widely adopted manufacturing technology due to its design flexibility, low cost, and capability for rapid prototyping. However, the mechanical performance of FDM-printed components is strongly influenced by internal structural parameters such as infill pattern and infill density, in addition to the intrinsic material behaviour. This study investigates the structure–property relationship between infill topology, density, and mechanical performance of PLA …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 4, Issue 1, 2026 · pp. 26–37 Read article
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Design, Mathematical Modeling, and Dynamic Optimization of a Speed Breaker-Based Vehicular Kinetic Energy Harvester
Abstract: Decentralized energy harvesting methods are becoming more popular due to rapid urbanization and the rising need for sustainable infrastructure. The road-embedded vehicle kinetic energy harvester (VKEH) design, mathematical modelling, and experimental validation are presented in this work. This paper presents the structural engineering, continuum mathematical modeling, and experimental validation of an optimized road-embedded vehicular kinetic energy harvester (VKEH). The mechanism utilizes a spring- loaded, low-friction rack-and-pinion transmission coupled with a …
Published in International Journal of Electrical Power and Machine Systems · Vol. 4, Issue 2, 2026 Read article
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Advancements in Molecular Engineering: Innovations at the Nexus of Chemistry and Technology
Abstract: Molecular engineering, a frontier of chemistry, merges precision and innovation to design and assemble molecular structures with unprecedented control. This abstract explores recent advances, highlighting key breakthroughs and their transformative impacts. Starting with its roots in chemical synthesis and materials science, it traces the evolution towards rational design driven by computational tools and advanced characterization techniques, enabling tailored molecular architectures. A focal point is programmable molecules, where DNA nanotechnology principles …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 2, 2023 · pp. 37–43 Read article
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Polymer Electrolytes for Flexible Energy Storage
Abstract: The research explores polymer electrolytes as promising materials for flexible energy storage applications, driven by the growing demand for wearable and portable electronics. Polymer electrolytes, including solid, gel, and composite types, offer key advantages such as mechanical flexibility, lightweight design, and improved safety over traditional liquid electrolytes. This study reviews recent developments in materials like polyethylene oxide (PEO), polyvinylidene fluoride (PVDF), and ionic liquid-based systems, focusing on their ionic conductivity, …
Published in International Journal of Advance in Molecular Engineering · Vol. 4, Issue 1, 2026 · pp. 27–35 Read article
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Evaluation of Modified Nanoparticles' Effects on Polypropylene Composites
Abstract: Numerous sectors use nanoparticles and nanocomposites in a range of applications, including medicine, textiles, cosmetics, agriculture, optics, food packaging, optoelectronics, semiconductors, aerospace, building materials, and catalysis. Polymeric nanocomposites, which combine organic polymers with inorganic nanoparticles, are a novel family of materials that perform better than their microparticle counterparts. They should therefore enhance the field of engineering applications. A polymer matrix's characteristics can be drastically changed by the addition of inorganic …
Published in International Journal of Pollution: Prevention & Control · Vol. 1, Issue 2, 2023 · pp. 23–34 Read article
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Viral Chronicles: The Ever-Evolving Saga of COVID-19
Abstract: Coronaviruses, belonging to the family of RNA viruses, have recently captured global attention owing to their remarkable ability to infect a diverse array of species, ranging from animals to humans. These viral agents, recognized by their characteristic crown-like morphology when observed through electron microscopy, have a historical association with zoonotic diseases. Previous examples include Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The term "Corona" …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 16–25 Read article
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Phase – Field Modeling of Brittle and Ductile Fracture Under Complex Loading Conditions
Abstract: Phase-field modeling has emerged as a powerful computational framework for predicting fracture behavior in engineering materials, offering a unified description of crack initiation, propagation, branching, and coalescence without the need for explicit crack tracking. This study presents an in-depth examination of phase-field modeling applied to both brittle and ductile fracture under complex loading conditions, including multiaxial stress states, cyclic loading, thermal gradients, and dynamic impact. The phase-field approach regularizes the …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 13–18 Read article
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Complex Space-Time and the Structure of Relativistic Quantum Theory
Abstract: Relativistic quantum mechanics was developed to reconcile the principles of quantum mechanics with Einstein’s theory of relativity. Despite its success in describing high-energy particles, the theory continues to face unresolved conceptual and mathematical difficulties, particularly in relation to the nature of time, causality, and relativistic consistency. In recent years, the idea of extending space-time into the complex domain has emerged as a useful and potentially meaningful approach to these problems. …
Published in Recent Trends in Mathematics · Vol. 3, Issue 1, 2026 · pp. 22–27 Read article
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Fracture Analysis of Functionally Graded Material (FGM) Plates Using Extended Finite Element Method: A Review.
Abstract: Functionally Graded Materials (FGMs), have drawn a lot of interest in various engineering applications due to their superior mechanical properties and ability to withstand extreme conditions. Fracture analysis in FGMs focuses on understanding how cracks initiate and propagate within these complex materials. The stress distribution becomes irregular due to spatial property variations which produces different crack paths than what occurs in homogeneous materials. The examination of FGM plates under fracture …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 4, Issue 1, 2026 · pp. 9–15 Read article
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Electromechanical Modeling of Microscale Fluidic Systems with Electro Kinetic
Abstract: Due to their capacity to carry out complex fluid manipulations at the microscale, microfluidic systems have become more popular in a variety of applications. For a variety of industries, including biomedical diagnostics, chemical analysis, and environmental monitoring, achieving precise and effective fluid control is essential. The electromechanical modeling of microscale fluidic systems using electro kinetic actuation is the main topic of this research study. We propose a thorough framework for …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 1, Issue 1, 2023 · pp. 18–22 Read article