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227 articles for “Genetics of the Disease”
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Evaluation of Anaesthetic Protocol for Zebrafish Embryo (Danio rerio): Lignocaine Combined with Diazepam and Ketamine with different doses Temperature Modulation
Abstract: Zebrafish (Danio rerio) model is economically viable and scientifically significant to identify several human diseases. It has genetic homology to humans (80-85%). Its other advantages are high reproductive success, embryo and larvae transparency and rapid development. Also compared to mammals, the maintenance cost of Zebrafish is lower. Ethyl 3-aminobenzoate methane sulfonate (MS-222) is known as the standard fish Anaesthetic and widely used in Zebrafish, but it can have adverse effects …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 2, 2020 · pp. 16–32 Read article
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Viral Elimination Strategies for Musa spp.
Abstract: Banana is one of the major crops in tropical parts of the world. The banana plant is susceptible to many diseases due to the less genetic diversity in its popular cultivars. Particularly viral diseases can severely destruct quantity and quality of the crop. Four major banana infecting viruses doing the damage- banana bunchy top virus, banana streak virus, banana bract mosaic virus, cucumber mosaic virus; two other viruses- banana mild …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 1, 2018 · pp. 7–14 Read article
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Host Interface of Cystic Fibrosis and P. aeruginosa
Abstract: A clash between microbial infection and host immunity can contribute to multiple diseases. Cystic fibrosis is one of those diseases. It’s an autoimmune disorder and hyperinflammatory disease, caused by pseudomonas aeruginosa, it’s the most predominant pathogen causing this disease. The progression of the lung infection cystic fibrosis is driven by host pathogen interface that focuses on the host and the bacterial factors. The disease has an interplay between the host, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 9–31 Read article
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Study on Chemical Insights into Alzheimer's Disease: Amyloid Beta and Tau Protein Interactions
Abstract: Background: Alzheimers disease (AD) is the most prevalent form of dementia, affecting millions of individuals worldwide and posing significant challenges to healthcare systems. The disease is characterized by a gradual decline in cognitive functions, particularly memory, reasoning, and the ability to perform daily activities. Aim & objective: To study chemical insights in alzheimers disease, especially amyloid beta and tau protein interactions Results & discussion: The results of this review highlight …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 37–46 Read article
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Immunology as Applied to Farm Animal Welfare: General Principles and Interventions
Abstract: Animal welfare is a state of animal’s well-being as indicated by scientific evidence and preferably quantifiable read-out of its health, nourishment, behavior and living conditions. Farm animals are reared for food and other purposes in different production systems. Farm animal welfare, particularly in intensive production systems, is an emerging concern of society at large, consumers of farm animal-source food in particular. Changing climate and weather patterns, intensive crop-farming and high-density …
Published in Research and Reviews : A Journal of Immunology · Vol. 8, Issue 1, 2018 · pp. 1–13 Read article
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Beyond Generalized Treatment: The Future is Personalized Medicine
Abstract: Personalized medicine, which is also called as precision medicine, is reestablishing the view of new healthcare by replacing the traditional "one-size-fits-all" approach with individual therapies made according to a patients unique genomic organization, environment, and lifestyle. This article talks about the scientific foundation, important applications, ethical challenges, and the significant potential of personalized medicine in enhancing the clinical outcomes. From oncogenic and genetic disorders to chronic diseases, the addition of …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 Read article
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Outcome of the Ayurvedic medication on a patient with Sickle cell anaemia – A single case study
Abstract: Sickle cell disease is caused by genetic modification of β-globin (HBB). The result of clinical syndromes is characterized by chronic hemolytic anemia and can be complicated by vaso-occlusion and vasculopathy which can lead to severe and chronic organ damage and premature death. A 17-year-old female patient was diagnosed with sickle cell anemia with symptoms of severe weakness, shortness of breath, loss of appetite, constipation, severe calf pain, chest pain, abdominal …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2022 · pp. 1–8 Read article
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The Unseen World Within: Decoding the Intricacies of Gut Microbiota and Its Impact on Human Health
Abstract: This comprehensive review delves into the multifaceted role of the gut microbiota in human health, elucidating its impact on diverse physiological processes, immune responses, and metabolic diseases. The intricate interplay of diet, genetics, and environmental factors is explored in shaping the composition and function of the gut microbiota, with consequential effects on conditions ranging from metabolic disorders to inflammatory bowel diseases and mental health. Therapeutic interventions, including probiotics, prebiotics, and …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 12–21 Read article
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A Case Report on Alport Syndrome which ends up with Allograft Rejection due to Anti-GBM Disease
Abstract: Alport syndrome (AS) is a condition which is genetically inherited and is characterized by abnormalities in the basement membrane of the kidney, ear and eye as well. It is one of the spectra of diseases representing hereditary nephritis, which inevitably leads to end-stage renal disease (ESRD). Sensorineural hearing loss (SNHL) is also a characteristic feature in AS. The hearing abnormality begins during late childhood or early adolescence and 90% of …
Published in Research and Reviews: A Journal of Medicine · Vol. 9, Issue 3, 2019 · pp. 1–4 Read article
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Disease: A Major Stumbling Block in the Growth of Aquaculture
Abstract: Aquaculture plays a crucial role in ensuring food security, fostering economic development, and providing recreational opportunities worldwide. However, the intensification of aquaculture practices has led to a surge in environmental challenges, including water pollution, soil acidification, eutrophication, chemical contamination, and the spread of diseases. Among these, diseases caused by bacteria, viruses, fungi, and parasites pose significant threats to the sustainability of global aquaculture. Despite the implementation of various diagnostic methods …
Published in International Journal of Marine Life · Vol. 1, Issue 1, 2024 · pp. 25–28 Read article
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The Significance and Correlation of Biochemical Parameters-related to Bone Diseases
Abstract: The chemical composition, mass and property of bones are controlled by various factors which include decreased mineral intake or absorption, defects in Vitamin D absorption or activation. Bone diseases are also influenced by growth factors, estrogen, testosterone, insulin, Parathyroid, Thyroid, and Cortisol hormone. Our study handles various human blood and urine samples ranging between the ages of 25–50 years for the above mentioned parameters which include calcium, alkaline phosphatases, phosphorous, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 33–36 Read article
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Examining the Role of Synthetic Biology in Cellular Restoration Mechanisms
Abstract: Synthetic biology has emerged as a transformative field with the potential to revolutionize cellular repair mechanisms, offering innovative solutions to repair damaged DNA, stabilize proteins, regenerate tissues, and treat a wide range of diseases. By combining principles from genetic engineering, biotechnology, and computational biology, synthetic biology enables the design of cellular systems capable of performing functions that repair cellular damage and restore normal cellular processes. This article explores the application …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 19–29 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Beejdushti: A Conceptual Study
Abstract: The appreciation of genetic factors as arbiters of human disease is a relatively recent development in medical history. Scattered references to inheritance of biological characteristics may be found in the records of several millennia. In which comes the Ayurvedic texts. In Ayurvedic texts the genetic concept of inheritance is beautifully described in Caraka Sharir Sthan. Although Other Authors also described in direct or indirect way the genetic basis of inheritance …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 4, Issue 2, 2015 · pp. 48–53 Read article
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article
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An Overview on the Management cum Treatment of Nephropathy in Type-1 Diabetes Mellitus
Abstract: The motive of this review is to keep updated with the medical nonfictions, the projected early natural arrangement of diabetic nephropathy, the theories behind the root of its pathogenesis pathophysiology, diagnosis and its supervision. Type 1 diabetes is an autoimmune disease characterized by advanced destruction of pancreatic beta cells by genetic and environmental factors which primes to an absolute necessity of insulin for survival and conservation of health; while Diabetic …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 3, 2020 · pp. 19–38 Read article
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Gene Editing and Its Implications for Animal Health
Abstract: Gene editing technologies, particularly CRISPR/Cas9, have revolutionized the field of veterinary medicine, offering unprecedented opportunities for precise genetic manipulation in animals. This review explores the potential applications of gene editing in enhancing animal health, focusing on disease resistance, breeding programs, and the associated ethical considerations. Beginning with an overview of gene editing techniques, we discuss the utility of CRISPR/Cas9 in targeted genetic modifications and compare its advantages and limitations relative …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 1, 2024 · pp. 13–17 Read article
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Potential Etiologic Link and Association between Mycobacterium avium subspecies paratuberculosis and Crohn’s Disease in Humans
Abstract: Mycobacterium avium subspecies paratuberculosis, the cause of incurable, chronic enteritis called as Johne’s disease or paratuberculosis in animals, has also been associated with Crohn’s disease in human beings. Scientific opinion is divided on the possible role of Mycobacterium avium subspecies paratuberculosis in the etiopathogenesis of Crohn’s disease. Though etiology of Crohn’s disease is still unclear, however, in addition to genetic and environmental factors, microorganisms have been considered as potential agents. …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 1, 2012 · pp. 13–26 Read article
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Rust Resistance in Hexaploid Wheat (Triticum aestivum L. em Thell)
Abstract: Wheat (Triticum aestivum L. Em Thell) is the ‘golden grain’ of the cereals and plays a vital role in the contribution of global food. Wheat yield in India grew at a rate of 3.5% during 1940–82 and had a sudden decline during the next two decades to 2.9%. This decline can be attributed due to: (1) lack of improvement in the genetic yield potential, and (2) susceptibility to diseases. The …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 7, Issue 1, 2018 · pp. 11–21 Read article
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Population Genetics and Diversity of Human Adenovirus in Two Tertiary Hospitals in Southern Nigeria
Abstract: The study of dynamic changes in genetic heterogeneity can shed light on the evolution of viruses because it is known that the genetic variety of viral populations within their hosts affects disease progression, treatment outcome, medication resistance, cell tropism, and transmission risk. Our study's primary goal is to identify trends in the genetic makeup and variety of human adenoviruses using samples taken from children who attend two distinct tertiary hospitals …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 37–44 Read article