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218 articles for “Drug toxicity”
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Drug-Resistant TB—Problem and Management: a Review
Abstract: Tuberculosis (TB) is one of the oldest diseases known to affect humans. TB is a major cause of death worldwide. The bacteria Mycobacterium tuberculosis is the causative agent of TB. It usually affects the lungs and causes pulmonary TB. The intestine, meninges, bones, joints, lymph glands, skin and other tissues of the body are also affected. TB caused by drug-susceptible strains is curable in virtually all the cases after proper …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 3, 2019 · pp. 30–34 Read article
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Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
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The Ames Test in Twenty-first Century
Abstract: Since the 19th century, industrial development has increased exposure to mutagens and possible carcinogens. In order to avoid these health risks, several techniques have been developed to recognize genotoxins. In the 1970s, Dr. Bruce Ames and colleagues, studying the histidine operon of Salmonella typhimurium, observed that histidine (−) auxotroph mutants were reverted to histidine (+) upon exposure to a mutagen. The researchers further observed that known carcinogens were mutagenic to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 23–37 Read article
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Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)
Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 62–79 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Comparison of the Effects of Voriconazole and its Nanogel form on Aspergillus Flavus Isolates in Vitro
Abstract: Aspergillus species are one of the most critical environmental fungi and are considered as a severe factor in causing hospital infections of foreign origin. Objective: Aspergillus flavus is a saprophytic and pathogenic fungus and is found all over the world. In clinical isolates, the voriconazole drug effectively affects more than 95% of Aspergillus isolates. These common drugs have limitations for maximum effect in patients, so nanomedicines are designed and manufactured …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 3, 2024 · pp. 14–20 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 17–30 Read article
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Child-Friendly Innovation: A New Era in Pediatric Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 26–34 Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Computational Biomodeling: Transforming Drug Design with Advanced Simulations
Abstract: Computational biomodeling has emerged as a transformative approach in the field of drug discovery, significantly enhancing the efficiency and precision of identifying and optimizing potential drug candidates. This article explores the various computational techniques utilized in drug design, including molecular docking, molecular dynamics (MD) simulations, free energy calculations, and virtual screening, and examines how these methods collectively contribute to the drug development process. The integration of these advanced simulations allows …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 24–29 Read article
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Exploring Phytochemicals of Ficus religiosa against Corona Virus Protein using Molecular Modeling Techniques
Abstract: The current worst pandemic situation is brought about by novel Severe acute respiratory syndrome coronavirus 2 causing Covid-19 disease. The world fights against it with vaccines, self-sanitation techniques and drugs like ribavirin, beta-interferon and remdesivir which has not solved the problem to the desired extent. With technical and scientific developments in molecular biology field, though the genome and proteome of the organism is explored, potent drugs against it is still …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 18–26 Read article
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Carbon Nano Tubes: New Techniques for Cancer Treatment
Abstract: Carbon Nano tubes (CNTs) have been recently introduced as a novel carrier system in the biomedical field and produce small and large therapeutic molecules. CNTs have attracted increasing attention for their versatile applications. Based on layers of CNTs, CNTs are generally divided into two categories: single-walled carbon Nano tubes (SWCNTs), multi-walled carbon Nano tubes (MWCNTs). It shows the unique properties and cylindrical shape structure. It shows a greater advantage in …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 28–39 Read article
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Nanoparticle Synthesis and Assessment of Toxicological Effects on Drosophila Melanogaster: A Review
Abstract: Nanoparticles are widely used for many decades now, in various fields like medicine, health, drug delivery, etc. It is observed that nanoparticles synthesized using physical or chemical methods possess toxic nature when exposed to a biological system. To overcome the harmful effects of nanoparticles a more eco-friendly approach known as green synthesis was applied during recent decades. In the green synthesis approach, biological entities are used for the production of …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 11, Issue 3, 2021 · pp. 1–8 Read article
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Personalized Therapy Using Drug Delivery Devices
Abstract: The persistent challenge in modern medicine lies in inter-patient heterogeneity, rendering standardized drug dosing protocols suboptimal for many chronic conditions. Traditional pharmacokinetics fail to account for real-time biological fluctuations, leading to cycles of ineffective treatment or dose-limiting toxicity. This paper explores the critical intersection of advanced drug delivery devices (DDDs) and personalized medicine, positioning these technologies as the vital link translating genomic and biological data into tangible, patient- specific interventions. …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 53–62 Read article
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Pharma Tech: Leveraging Software for Drug Development & Clinical Research
Abstract: The pharmaceutical sector is progressively adopting software solutions to enhance the drug development process and optimize clinical research results. Drug development is a time-consuming, expensive, and intricate process that traditionally requires extensive laboratory research, preclinical testing, and several stages of clinical trials. Software tools are revolutionizing these stages by improving efficiency, minimizing errors, and speeding up timelines. During preclinical testing, predictive software tools are used to model toxicological effects and …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 11–19 Read article
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Evaluation of the anti diabetic effects of ethanolic root extract from polyalthania longifora in diabetic rats induced by streptozotin and nicotinamide with considaertion of toxocological aspects
Abstract: The root of Polialthia Longifolia was selected for the evaluation of antidiabetic potential in STZ-nicotinamide induced diabetic rat model.The root extract was extracted by hot percolation using ethanol as a solvent in soxhlet apparatus and the preliminary phytochemical screening was performed and it shows that the ethanolic root extract of Polialthia Longifolia contains alkaloids, glycosides, flavonoids and tannins. Safety profile is essential for the drugs obtained from the plant origin. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 37–50 Read article
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Concept of Stability of Drugs in Unani Perspective
Abstract: Stability of a pharmaceutical product can be defined as the capability of a particular formulation, in a specific container closure system to remain within its physical, chemical, microbiological, therapeutic and toxicological specifications. According to ancient Unani physicians shelf life of a drug is determined by organoleptic characters of the drugs i.e., external features, color, smell, taste, consistency, structure, weight, clarity, cleanliness and freshness. In classical Unani literature there is a …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 4, Issue 2, 2015 · pp. 1–4 Read article
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Quality Control and Assurance Practices in Modern Pharmaceutical Industry
Abstract: This brief overview outlines the global techniques for figuring out the prevalence of geotaxis impurities (residual solvents and various inorganic and organic impurities) in medications. It is now necessary to reveal a pharmaceutical product's purity and impurity profiles due to both national and international regulations. These elements are discussed, together with the kinds of impurities, their origins, their control, and regulatory issues, as well as the significance of pharmaceutical quality, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 07–13 Read article